OSM-LIF Receptors

Cell surface receptors formed from the dimerization of LIF RECEPTOR ALPHA SUBUNIT with CYTOKINE RECEPTOR GP130. Although originally described as receptors for LEUKEMIA INHIBITORY FACTOR these receptors also bind the closely-related protein ONCOSTATIN M and are referred to as both LIF receptors and type I oncostatin M receptors.

Also Known As:

Receptors, OSM-LIF; LIF Receptors; Leukemia Inhibitory Factor Receptors; Leukemia Inhibitory Factor-Oncostatin M Shared Receptor; Oncostatin M Type I Receptor; Oncostatin M-Leukemia Inhibitory Factor Shared Receptor; Leukemia Inhibitory Factor Oncostatin M Shared Receptor; Oncostatin M Leukemia Inhibitory Factor Shared Receptor; Receptors, LIF; Receptors, OSM LIF; Leukemia Inhibitory Factor Receptor; Receptors, Leukemia Inhibitory Factor

Networked: 84 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        OSM-LIF Receptors: 84
        Cytokine Receptor gp130: 208
        Leukemia Inhibitory Factor Receptor alpha Subunit: 2

Experts

1.	Ding, Yufeng: 2 articles (01/2022 - 01/2019)
2.	Shao, Jialiang: 2 articles (01/2022 - 01/2019)
3.	Wang, Xiang: 2 articles (01/2022 - 01/2019)
4.	Wang, Xiongjun: 2 articles (01/2022 - 01/2019)
5.	Yu, Hua: 2 articles (01/2022 - 01/2019)
6.	Clements, Miranda E: 2 articles (12/2021 - 01/2021)
7.	Johnson, Rachelle W: 2 articles (12/2021 - 01/2021)
8.	Altwegg, Kristin A: 2 articles (08/2021 - 08/2019)
9.	Li, Xiaonan: 2 articles (08/2021 - 08/2019)
10.	Nair, Hareesh B: 2 articles (08/2021 - 08/2019)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 10/01/2015 - "In the present study, decreased expression of leukemia inhibitory factor receptor (LIFR) was demonstrated in HCC, and its expression levels were even lower in HCC with metastasis. " 06/01/2018 - "Mechanistic investigation determined that lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR), which is designated as a metastasis suppressor in BC. " 08/01/2016 - "In the present study, we report that leukemia inhibitory factor receptor (LIFR) suppresses tumorigenesis and metastasis of PC cells both in vitro and in vivo. " 06/01/2023 - "To investigate the relationships of leukemia inhibitory factor receptor (LIFR) with cervical cancer invasion and metastasis. " 06/01/2023 - "Role and mechanism of leukemia inhibitory factor receptor in cervical cancer invasion and metastasis."
2.	Breast Neoplasms (Breast Cancer) 12/01/2021 - "Downregulation of leukemia inhibitory factor receptor (LIFR), a known breast tumor suppressor, enables otherwise dormant MCF7 human breast cancer cells to become aggressively osteolytic. " 01/01/2021 - "Leukemia inhibitory factor receptor (LIFR) promotes a dormancy phenotype in breast cancer cells and LIFR loss is correlated with poor patient survival. " 12/01/2016 - "We discover that feedback activation of leukemia inhibitory factor receptor (LIFR) signaling in breast cancer limits the response to HDAC inhibition. " 07/10/2015 - "MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway." 12/05/2012 - "YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer."
3.	Leukemia 12/01/2012 - "Leukemia inhibitory factor receptor α-chain: a potential method for acute promyeloid leukemia therapy." 10/01/2014 - "The distal cytoplasmic motifs of the leukemia inhibitory factor receptor α-chain (LIFRα-CT3) and its TAT fusion protein (TAT-CT3) can independently suppress cell viability and induce myeloid differentiation in human leukemia HL-60 cells in our previous studies. "
4.	Carcinogenesis 08/01/2016 - "In the present study, we report that leukemia inhibitory factor receptor (LIFR) suppresses tumorigenesis and metastasis of PC cells both in vitro and in vivo. "
5.	Tubal Pregnancy 01/01/2015 - "This study aimed to explore the association of tubal pregnancy with leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues. " 01/01/2015 - "Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antisense RNA (Anti-Sense RNA)
3.	Long Noncoding RNA
4.	Leukemia Inhibitory Factor
5.	MicroRNAs (MicroRNA)
6.	RNA (Ribonucleic Acid)
7.	Glycoproteins (Glycoprotein)
8.	Cytokines
9.	Cytokine Receptors (Cytokine Receptor)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Therapeutics
2.	Cell- and Tissue-Based Therapy (Cell Therapy)
3.	Kidney Transplantation