Leukemia Inhibitory Factor

An INTERLEUKIN-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. Leukemia inhibitory factor binds to and acts through the lif receptor.

Also Known As:

AM424; Cholinergic Differentiation Factor; D Factor (Leukemia Inhibitory Factor); Differentiation-Stimulating Factor; Emfilermin; Myeloid Differentiation-Stimulating Factor; Differentiation Factor, Cholinergic; Differentiation Stimulating Factor; Differentiation-Stimulating Factor, Myeloid; Inhibitory Factor, Leukemia; Myeloid Differentiation Stimulating Factor

Networked: 636 relevant articles (7 outcomes, 60 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Levison, Steven W: 6 articles (01/2022 - 01/2002)
2.	Hu, Wenwei: 5 articles (04/2022 - 07/2011)
3.	Markert, Udo R: 5 articles (10/2017 - 09/2003)
4.	Park, Jong-In: 5 articles (10/2013 - 02/2005)
5.	Collier, Lisa A: 4 articles (01/2020 - 01/2017)
6.	Davis, Stephanie M: 4 articles (01/2020 - 01/2017)
7.	Pennypacker, Keith R: 4 articles (01/2020 - 01/2017)
8.	Hellings, Niels: 4 articles (03/2015 - 02/2006)
9.	Stinissen, Piet: 4 articles (03/2015 - 02/2006)
10.	Zang, Dawei: 4 articles (01/2014 - 08/2003)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2023 - "In this study, we observed that leukemia inhibitory factor (LIF), the serum level of which was highly increased in those with solid tumors, could specifically attenuate the cytotoxic function of peripheral γδT cells in patients with CRC. " 06/01/2003 - "A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer." 03/01/1999 - "The present study investigated the presence of leukemia inhibitory factor in cartilage tissue harvested from cartilage-forming bone tumors. " 03/01/1999 - "Expression of leukemia inhibitory factor by cartilage-forming tumors of bone: an immunohistochemical study." 01/01/2023 - "We identify tumor produced IL-1α and leukemia inhibitory factor (LIF) acting on splenic HSPCs and splenic niche cells, respectively. "
2.	Myocardial Infarction 10/26/2007 - "The aim of the present study was to investigate (1) the effect and underlying signal transduction pathways of leukemia inhibitory factor (LIF) and bone-morphogenic protein-2 (BMP-2)-induced mouse ES cell (mES-D3 line) differentiation into cardiomyocytes (CMC) and (2) the efficacy of CMC precommitted mES cells for functional and anatomical cardiac repair in surgically-induced mouse acute myocardial infarction (AMI) model. " 01/01/2016 - "Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction." 12/01/2004 - "Myocardial gene transfer of leukemia inhibitory factor preserved cardiac tissue, geometry, and function after myocardial infarction in rats." 08/12/2003 - "Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction." 12/29/2021 - "Oncostatin M (OSM) and leukemia inhibitory factor (LIF) signaling protects the heart after myocardial infarction (MI). "
3.	Stroke (Strokes) 01/01/2019 - "Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats." 01/01/2020 - "The goal of this study was to determine whether leukemia inhibitory factor (LIF) promotes anti-inflammatory activity after stroke in a sex-dependent manner. " 01/01/2019 - "Neuroprotective activity of leukemia inhibitory factor is relayed through myeloid zinc finger-1 in a rat model of stroke." 01/01/2019 - "Previously, this lab showed that leukemia inhibitory factor (LIF) promoted recovery after stroke through antioxidant enzyme upregulation. "
4.	Endotoxemia 04/01/1992 - "Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: synergistic effect with interleukin 1 and tumor necrosis factor."
5.	Experimental Autoimmune Neuritis 12/01/2002 - "Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis."

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-4 (Interleukin 4)
4.	Interleukin-10 (Interleukin 10)
5.	Interleukin-1 (Interleukin 1)
6.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
7.	Interleukin-1 Receptors (Interleukin 1 Receptor)
8.	antiglomerular basement membrane antibody
9.	Cytokines
10.	Leukemia Inhibitory Factor

Related Therapies and Procedures

1.	Transplantation
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Bioreactors (Bioreactor)
5.	Axotomy