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Opsoclonus-Myoclonus Syndrome (Kinsbourne Syndrome)

A neurological condition that is characterized by uncontrolled rapid irregular movements of the eye (OPSOCLONUS) and the muscle (MYOCLONUS) causing unsteady, trembling gait. It is also known as dancing eyes-dancing feet syndrome and is often associated with neoplasms, viral infections, or autoimmune disorders involving the nervous system.
Also Known As:
Kinsbourne Syndrome; Dancing Eyes, Dancing Feet Syndrome; Dancing Eyes-Dancing Feet Syndrome; Myoclonic Encephalopathy of Infants; Opsoclonus Myoclonus; Opsoclonus Myoclonus Ataxia; Dancing Eyes Dancing Feet Syndrome; Infants Myoclonic Encephalopathies; Infants Myoclonic Encephalopathy; Myoclonus, Opsoclonus; Opsoclonus Myoclonus Syndrome; Paraneoplastic Opsoclonus Myoclonus Ataxia; Paraneoplastic Opsoclonus-Myoclonus Ataxia
Networked: 287 relevant articles (13 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neuroblastoma
2. Neoplasms (Cancer)
3. Paraneoplastic Syndromes (Paraneoplastic Syndrome)
4. Encephalitis (Encephalitis, Rasmussen)
5. Ataxia (Dyssynergia)

Experts

1. Pranzatelli, Michael R: 28 articles (01/2018 - 11/2002)
2. Tate, Elizabeth D: 28 articles (01/2018 - 11/2002)
3. Dalmau, Josep: 10 articles (01/2021 - 03/2003)
4. Graus, Francesc: 10 articles (01/2021 - 03/2003)
5. Travelstead, Anna L: 10 articles (06/2012 - 07/2004)
6. Blaes, Franz: 9 articles (01/2021 - 04/2002)
7. McGee, Nathan R: 7 articles (01/2018 - 02/2012)
8. Colliver, Jerry A: 7 articles (05/2013 - 10/2008)
9. McKeon, Andrew: 6 articles (01/2022 - 09/2010)
10. Verhulst, Steven J: 6 articles (01/2014 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Opsoclonus-Myoclonus Syndrome:
1. Dexamethasone (Maxidex)FDA LinkGeneric
2. Intravenous Immunoglobulins (IVIG)FDA Link
3. SteroidsIBA
4. Rituximab (Mabthera)FDA Link
5. Immunoglobulin G (IgG)IBA
01/01/2022 - "A Case of Opsoclonus-Myoclonus-Ataxia With Neuronal Intermediate Filament IgG Detected in Cerebrospinal Fluid."
01/01/2021 - "NK Cell-mediated Neuroblastoma Cell Lysis is Enhanced by IgG From Patients With Pediatric Opsoclonus-Myoclonus Syndrome."
06/16/2020 - "Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma."
08/01/1995 - "Before chemotherapy, she received intravenously administered IgG, 1 gm/kg, for 2 days; within 48 hours of the first dose, there was significant improvement of the opsoclonus-myoclonus and ataxia. "
05/01/1989 - "Serum immunoreactivity was revealed using HRP-conjugated anti-human IgG. Significant findings included: (1) patients with epilepsy had an increased incidence of anti-CNS reactivity as revealed on frontal cortex immunoblots (p less than 0.05) but not on cerebellar immunoblots; (2) there was an increase in the incidence of immunoblot reactivity with age in the controls and the neurology cases; (3) there was an increased incidence of immunoblot reactivity in those cases with a presumed inflammatory central or peripheral neurologic disease; (4) in six additional cases with opsoclonus-myoclonus there was cerebellar-specific immunoreactivity with identified antigenic molecular weights of 27 and 35, and 62 kDaltons; (5) in 31 additional cases of systemic lupus erythematosus there was significant immunoblot reactivity (p less than 0.001) when compared to a subset of age-matched controls. "
6. Clonazepam (Rivotril)FDA LinkGeneric
7. Adrenocorticotropic Hormone (ACTH)FDA Link
8. AntibodiesIBA
9. Immunoglobulin M (IgM)IBA
01/01/2009 - "In this review, data on the use of rituximab is presented from 92 studies involving 1197 patients with the following diseases: systemic lupus erythematosus, idiopathic thrombocytopenic purpura, anti-neutrophil cytoplasmic antibody associated vasculitis, Grave's disease, autoimmune hemolytic anemia, pemphigus vulgaris, hemophilia A, cold agglutinin disease, Sjogren's syndrome, graft vs. host disease, thrombotic thrombocytopenic purpura, cryoglobulinemia, IgM mediated neuropathy, multiple sclerosis, neuromyelitis optica, idiopathic membranous nephropathy, dermatomyositis, and opsoclonus myoclonus. "
04/01/2007 - "Recommendations for use of IVIG were made for 14 conditions, including acute disseminated encephalomyelitis, chronic inflammatory demyelinating polyneuropathy, dermatomyositis, diabetic neuropathy, Guillain-Barré syndrome, Lambert-Eaton myasthenic syndrome, multifocal motor neuropathy, multiple sclerosis, myasthenia gravis, opsoclonus-myoclonus, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, polymyositis, Rasmussen's encephalitis, and stiff person syndrome; IVIG was not recommended for 8 conditions including adrenoleukodystrophy, amyotropic lateral sclerosis, autism, critical illness polyneuropathy, inclusion body, myositis, intractable childhood epilepsy, paraproteinemic neuropathy (IgM variant), and POEMS syndrome. "
06/01/1997 - "Opsoclonus-myoclonus syndrome in childhood is associated with a distinctive pattern of serum IgM and IgG binding to neural tissues and antigens."
10. Gabapentin (Neurontin)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Drug Therapy (Chemotherapy)
4. Plasmapheresis
5. Combined Modality Therapy