Somatostatin-28

A 28-amino acid peptide with the same biological activities of somatostatin-14 but with a 14-amino acid extension at the N-terminal. SRIF-28 is the major form of somatostatin in the GASTROINTESTINAL TRACT.

Also Known As:

Networked: 42 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dimitrijevic, Ljiljana A: 1 article (08/2007)
2.	Kustrimović, Natasa Z: 1 article (08/2007)
3.	Mileva, Mićić V: 1 article (08/2007)
4.	Petrović-Djergović, Danica M: 1 article (08/2007)
5.	Rakin, Ana K: 1 article (08/2007)
6.	Ristovski, Jasmina S: 1 article (08/2007)
7.	Ahn, Chul Woo: 1 article (11/2005)
8.	Cha, Bong Soo: 1 article (11/2005)
9.	Hong, Soon Won: 1 article (11/2005)
10.	Kim, Dol Mi: 1 article (11/2005)

Related Diseases

1.	Pituitary Neoplasms (Pituitary Adenoma) 11/01/1986 - "Internalization and subcellular distribution of radiolabeled somatostatin-28 in mouse anterior pituitary tumor cells." 07/01/1985 - "Relationship between receptor binding and biopotency of somatostatin-14 and somatostatin-28 in mouse pituitary tumor cells." 08/01/1989 - "Previous studies have shown that somatostatin receptors on AtT-20 and GH3 pituitary tumor cells show relative preference for binding somatostatin-28 (S-28) and somatostatin-14 (S-14), respectively. " 06/24/2005 - "This may explain superior somatostatin-28 potency and provides a rationale for somatostatin ligand design to treat ACTH-secreting pituitary tumors." 07/01/1985 - "Activation of somatostatin-14 (S-14) receptors on mouse AtT-20 pituitary tumor cells by S-14 or somatostatin-28 (S-28) inhibits forskolin-stimulated cAMP synthesis and ACTH secretion. "
2.	Neoplasms (Cancer) 07/01/1985 - "The potency of somatostatin-28 (S-28) for regulating these processes in these tumor cells has not been reported. " 04/01/1989 - "Somatostatin receptor content was measured by receptor autoradiography on frozen tumor tissue sections using either a somatostatin-28 analog or a SRIH octapeptide analog (Tyr3-octreotide) as iodinated radioligands. " 01/01/1984 - "Somatostatin-28 and the cyclic hexapeptide analog of somatostatin cyclo(Pro-Phe-D-Trp-Lys-Thr-Phe) failed to influence the growth of this tumor. " 03/12/1998 - "Des-AA1,5-[Tyr2, D-Trp8, IAmp9]somatostatin was found to have a high affinity, comparable to that of the natural somatostatin-28, for sst1-expressing tumors such as prostate cancers. " 08/08/1997 - "Somatostatin-14, somatostatin-28, and prosomatostatin[1-10] are independently and efficiently processed from prosomatostatin in the constitutive secretory pathway in islet somatostatin tumor cells (1027B2)."
3.	Insulinoma 05/16/1988 - "The selective binding of somatostatin-28 (SS-28) to beta cells of hamster insulinoma was characterized using HPLC-purified 125I-[Leu8,D-Trp22,Tyr25]SS-28 or 125I-SS-28. " 03/01/1982 - "Saturable and high affinity binding sites have been obtained for an iodinated somatostatin-28 (SS-28) analog, [Leu8,D-Trp22,125I-Tyr25] SS-28, in a membrane preparation from hamster insulinoma, mainly composed of pancreatic beta-cells. " 03/01/2005 - "All insulinomas expressed high-affinity somatostatin receptors of subtype sst2, as shown by receptor autoradiography in vitro using 125I-[tyrosine3]-octreotide and 125I-[leucine8, Dtryptophan22, tyrosine25]-somatostatin-28 with an sst2 subtype-selective analogue. " 08/05/1992 - "Somatostatin-28 (SRIF-28) preferring receptors were solubilized from hamster beta cell insulinoma using the zwitterionic detergent 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate. " 12/08/1989 - "Somatostatin receptors of plasma membranes from beta cells of hamster insulinoma were covalently labelled with 125I-[Leu8,D-Trp22,Tyr25]somatostatin-28 (125I-somatostatin-28) and solubilized with the non-denaturing detergent Triton X-100. "
4.	Alzheimer Disease (Alzheimer's Disease) 10/01/2002 - "Interstitial cells subjacent to the entorhinal region expressing somatostatin-28 immunoreactivity are susceptible to development of Alzheimer's disease-related cytoskeletal changes." 08/18/1986 - "The relative proportions of both somatostatin-14 and its precursors somatostatin-28 and the 15 Kdalton prosomatostatin were evaluated by radioimmunoassay in the cerebrospinal fluid of patients with Alzheimer's disease. " 12/01/1995 - "Low cerebrospinal fluid concentrations of peptide histidine valine and somatostatin-28 in Alzheimer's disease: altered processing of prepro-vasoactive intestinal peptide and prepro-somatostatin."
5.	Somatostatinoma 11/01/1982 - "Somatostatin-28 like immunoreactivity was present in pancreatic islets cells and in the epithelial cells of the duodenum as well as in the duodenal somatostatinoma and in pancreatic tumour cells. " 11/01/2005 - "Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion." 11/01/1982 - "Indirect immunofluorescence techniques using specific antisera against somatostatin-28 were carried out in normal pancreas, duodenum, a somatostatinoma in the duodenum, and pancreatic tumour cells containing somatostatin-14 positive cells, in order to establish if somatostatin-28 is present in normal and pathological tissues. "

Related Drugs and Biologics

1.	Somatostatin (Somatotropin Release-Inhibiting Factor)
2.	Somatostatin Receptors (Somatostatin Receptor)
3.	Octreotide (Sandostatin)
4.	Adrenocorticotropic Hormone (ACTH)
5.	Peptides (Polypeptides)
6.	Insulin (Novolin)
7.	Vasopressins (Vasopressin)
8.	Pro-Opiomelanocortin (Proopiomelanocortin)
9.	Detergents (Detergent)
10.	prosomatostatin

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Induced Hypothermia