Keratin-3 (Keratin 3)

A type II keratin that is found associated with the KERATIN-12 in the CORNEA and is regarded as a marker for corneal-type epithelial differentiation. Mutations in the gene for keratin-3 have been associated with MEESMANN CORNEAL EPITHELIAL DYSTROPHY.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Aldave, Anthony J: 2 articles (01/2020 - 01/2015)
2.	Abd Ghafar, Norzana: 1 article (01/2021)
3.	Azmi, Muhammad Fairuz: 1 article (01/2021)
4.	Che Hamzah, Jemaima: 1 article (01/2021)
5.	Chua, Kien Hui: 1 article (01/2021)
6.	Ng, Sook Luan: 1 article (01/2021)
7.	Alkadi, Turad A: 1 article (01/2020)
8.	Buckshey, Arjun: 1 article (01/2020)
9.	Chung, Doug D: 1 article (01/2020)
10.	Cung, Le Xuan: 1 article (01/2020)

Related Diseases

1.	Wounds and Injuries (Trauma) 11/09/2019 - "This study highlights previously unknown effects of Bevacizumab on cultured putative limbal epithelial SC: a dose-related increase of keratin 3, an increase in VEGFA as well as a delay in scratch wound closure. " 01/01/2021 - "The percentage of wound closure was measured on day 0, 3, and 5. Expressions of cytokeratin 3 (CK3), cluster of differentiation 44 (CD 44), and connexin 43 (Cx43) were analyzed via qRT-PCR and immunocytochemistry. "
2.	Limbal Stem Cell Deficiency 09/01/2005 - "To evaluate and relate the clinical (including corneal sensitivity and tear function) and cytological (presence of goblet cells and cytokeratin 3- and 19-positive cells) features of limbal stem cell deficiency (LSCD). " 08/01/2003 - "The aim of this study was to investigate corneal limbal stem cell deficiency (LSCD) by means of the impression cytology (IC) technique, using antibodies against cytokeratin 19 (CK19) and cytokeratin 3 (CK3), and to evaluate the diagnostic potential of this approach. "
3.	Juvenile Epithelial of Meesmann Corneal Dystrophy 09/15/2008 - "Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation." 12/01/1997 - "In addition, we report four K12 mutations in Meesmann corneal epithelial dystrophy (MCD), an autosomal dominant disorder characterized by intraepithelial microcysts and corneal epithelial fragility in which mutations in keratin 3 (K3) and K12 have recently been implicated. " 01/01/2020 - "Meesmann epithelial corneal dystrophy (MECD) is a rare dominantly inherited disorder that is characterized by corneal epithelial microcysts and is associated with mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes. " 01/01/2015 - "To report potentially pathogenic mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes in two individuals with clinically diagnosed Meesmann corneal dystrophy (MECD). " 04/01/2013 - "Autosomal-dominant Meesmann epithelial corneal dystrophy without an exon mutation in the keratin-3 or keratin-12 gene in a Chinese family."
4.	Neoplasms (Cancer) 10/01/2016 - "Immunofluorescence staining was performed for ABCG2, tumor protein p63α, and cytokeratin 3 (K3). " 02/01/2010 - "Tumor cells are immunoreactive for Vimentin (4/4), Bcl-2 (4/4), CD99 (4/4), and CD56 (3/4), and focally for EMA (3/4) and Cytokeratin (3/4). " 08/26/2009 - "Subsequent Genotyping To 11 Known Corneal Gene Loci (COL8A2 [Collagen, Type VIII, Alpha-2], TACSTD2 [Tumor-Associated Calcium Signal Transducer 2], PIP5K3 [Phosphatidylinositol-3-Phosphate 5-Kinase, Type III], GSN [Gelsolin], KERA [Keratocan], VSX1 [Visual System Homeobox Gene 1], COL6A1 [Collagen, Type VI, Alpha-1], MMP9 [Matrix Metalloproteinase 9], KRT3 [Keratin 3]), and two putative loci, 3p14-q13 and 15q22.33-24) was undertaken using polymorphic markers, and haplotypes constructed. "
5.	Corneal Neovascularization 09/01/2019 - "While all animals displayed conjunctival cells on the corneal surface (by presence of goblet cells and/or keratin 13 expression) and corneal neovascularization, evidence of corneal epithelial regeneration was observed in animals that received RLMSC in the presence of HLE (by staining for keratin 3 and the absence of goblet cells). "

Related Drugs and Biologics

1.	Keratin-19 (Keratin 19)
2.	Antibodies
3.	Bevacizumab (Avastin)
4.	Keratin-12 (Keratin 12)
5.	Gelsolin
6.	Keratin-13 (Keratin 13)
7.	Collagen Type VI
8.	Collagen Type VIII
9.	Matrix Metalloproteinase 9 (Gelatinase B)
10.	Connexin 43 (Connexin43)