Keratin-12 (Keratin 12)

A type I keratin that is found associated with the KERATIN-3 in the CORNEA and is regarded as a marker for corneal-type epithelial differentiation. Mutations in the gene for keratin-12 have been associated with MEESMANN CORNEAL EPITHELIAL DYSTROPHY.

Also Known As:

Keratin 12; Cytokeratin-12; Cytokeratin 12

Networked: 27 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Allen, Edwin H A: 3 articles (03/2016 - 01/2013)
2.	Atkinson, Sarah D: 3 articles (03/2016 - 01/2013)
3.	McLean, W H Irwin: 3 articles (03/2016 - 01/2013)
4.	Moore, C B Tara: 3 articles (03/2016 - 01/2013)
5.	Aldave, Anthony J: 2 articles (01/2020 - 01/2015)
6.	Courtney, David G: 2 articles (03/2016 - 05/2014)
7.	Maurizi, Eleonora: 2 articles (03/2016 - 05/2014)
8.	Moore, Johnny E: 2 articles (03/2016 - 05/2014)
9.	Smith, Frances J D: 2 articles (03/2016 - 01/2013)
10.	Nubile, Mario: 2 articles (01/2016 - 08/2015)

Related Diseases

1.	Hereditary Corneal Dystrophies 03/01/2013 - "Severe Meesmann's epithelial corneal dystrophy phenotype due to a missense mutation in the helix-initiation motif of keratin 12." 05/29/2010 - "To report a novel missense mutation of the cornea specific keratin 12 (KRT12) gene in two generations of a German family diagnosed with Meesmann;s corneal dystrophy. " 05/29/2010 - "Identification of a novel mutation in the cornea specific keratin 12 gene causing Meesmann's corneal dystrophy in a German family." 06/21/2007 - "To determine if a mutation within the coding region of the keratin 12 gene (KRT12) is responsible for a severe form of Meesmann's corneal dystrophy. " 06/21/2007 - "A novel mutation of the Keratin 12 gene responsible for a severe phenotype of Meesmann's corneal dystrophy."
2.	Wounds and Injuries (Trauma) 01/01/2019 - "Corneal epithelial cytokeratin 12 and alpha smooth muscle actin indicative of functional tissue regeneration and wound contraction were observed in RCM surrounding both hydrogel types. " 11/21/2003 - "The purposes of this study are to compare the expression patterns of KSPGs and keratin 12 (K12) respectively by corneal keratocytes and epithelial cells after three different types of injuries; partial and total epithelial debridement and alkali burn. "
3.	Burns 11/21/2003 - "The purposes of this study are to compare the expression patterns of KSPGs and keratin 12 (K12) respectively by corneal keratocytes and epithelial cells after three different types of injuries; partial and total epithelial debridement and alkali burn. "
4.	Juvenile Epithelial of Meesmann Corneal Dystrophy 03/15/2016 - "Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy." 05/01/2008 - "To report a novel mutation in the keratin 12 gene (KRT12) found in a Japanese family in association with Meesmann corneal dystrophy (MECD). " 05/01/2008 - "A novel mutation in the cornea-specific keratin 12 gene in Meesmann corneal dystrophy." 12/01/2005 - "Meesmann corneal dystrophy (MECD): report of 2 families and a novel mutation in the cornea specific keratin 12 (KRT12) gene." 12/01/1997 - "Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy."
5.	Inflammation (Inflammations) 01/01/2016 - "One year after surgery, all patients underwent a biomicroscopic evaluation, central cornea impression cytology to detect cytokeratin 12 (CK12) positivity, and in vivo confocal microscopy of the central cornea and the sclerocorneal limbus to investigate the epithelial cellular morphology, limbal architecture, and corneal inflammation level. " 08/01/2015 - "Results of surgery were assessed considering clinical signs (successful: restoration of transparent, avascular, and stable corneal epithelium without neovascularization in central corneal surface; partially successful: recurrence of superficial neovascularization; failed: recurrent epithelial defects, pannus, and inflammation), phenotype of cells covering the corneal surface (conjunctivalized corneal surface: cytokeratin 12 [cK12]-negative and mucin 1 [MUC1]-positive cells; mixed epithelium: cK12-positive and MUC1-positive cells; corneal epithelium: cK12-positive and MUC1-negative cells), and cell morphologic features (corneal epithelium: multilayered polygonal and flat cells with hyperreflective nuclei; conjunctival epithelium: stratified cuboidal or polygonal cells, hyperreflective cytoplasm, and barely defined borders; epithelial transition: transition of epithelial cells from the cornea to the conjunctiva over the corneal surface). "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Alkalies
3.	Keratin-3 (Keratin 3)
4.	Keratin-13 (Keratin 13)
5.	Proteins (Proteins, Gene)
6.	Claudin-1
7.	Keratin-10
8.	Keratin-14 (Keratin 14)
9.	Aquaporin 5
10.	Hydrogels

Related Therapies and Procedures

1.	Debridement