Keratin-10

A type I keratin that is found associated with the KERATIN-1 in terminally differentiated epidermal cells such as those that form the stratum corneum. Mutations in the genes that encode keratin-10 have been associated with HYPERKERATOSIS, EPIDERMOLYTIC.

Also Known As:

Networked: 95 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shimizu, Hiroshi: 3 articles (07/2008 - 12/2004)
2.	Akiyama, Masashi: 3 articles (07/2008 - 12/2004)
3.	Zhou, Jing: 2 articles (12/2015 - 04/2015)
4.	Choate, Keith A: 2 articles (12/2015 - 04/2015)
5.	Korge, Bernhard P: 2 articles (11/2009 - 04/2006)
6.	Hausser, Ingrid: 2 articles (11/2009 - 04/2006)
7.	Krieg, Thomas: 2 articles (11/2009 - 04/2006)
8.	Arin, Meral J: 2 articles (11/2009 - 04/2006)
9.	Sakai, Kaori: 2 articles (07/2008 - 06/2007)
10.	Tsubota, Akiko: 2 articles (07/2008 - 06/2007)

Related Diseases

1.	Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma) 01/15/2012 - "The concept was first demonstrated by detecting the R156H-mutant gene of keratin 10 in Epidermolytic hyperkeratosis (EHK). " 05/01/2008 - "A case of epidermolytic hyperkeratosis with no facial involvement associated with mutation in keratin 10." 08/01/2007 - "Clinical manifestations and molecular analysis indicated that R156C mutation in keratin 10 gene (KRT10) causes a mild form of epidermolytic hyperkeratosis (EHK) in the presented case." 08/01/2007 - "R156C mutation of keratin 10 causes mild form of epidermolytic hyperkeratosis." 04/01/2006 - "A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis."
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/01/2014 - "A unique proteomic profiling with abnormal expression of alpha-1 antitrypsin and presence of keratin 10 in sera of psoriasis patients were observed that may constitute new and useful findings of psoriasis and offer a clue to a better understanding of the inflammatory pathway." 01/01/2005 - "The number of Ki-67 positive nuclei and the percentage of keratin-10 positive epidermal cells in flexural and plaque psoriasis were comparable. " 07/01/2004 - "In addition to the increased keratin 10 expression in ILVEN sine psoriasis, T cells relevant in the pathogenesis of psoriasis are markedly reduced in ILVEN sine psoriasis as compared to psoriasis. " 07/01/2005 - "Furthermore, a marked decreased expression of keratin 10 was observed in psoriasis (41% of epidermal area) contrary to atopic dermatitis (70%). " 10/01/2006 - "The patchy expression of keratin 6 in the inner margin became homogeneous in the centre of the psoriasis plaque and here was also coexpression of keratin 6 and keratin 10 in a single cell. "
3.	Papilloma (Papillomatosis) 07/01/2001 - "However, alpha3beta1 transgenic papillomas displayed a diminished proliferative capacity and were more highly differentiated as judged by BrdUrd incorporation and keratin 10 expression, respectively, than alpha2beta1 transgenic and wild-type papillomas. " 06/01/2000 - "In this study, we added bovine papilloma virus 1 (BPV) DNA into expression vectors with the lacZ gene driven by metallothionein and keratin 10 promoters, and we transferred them into keratinocytes in vivo using the naked DNA method, and measured beta-gal activity in keratinocytes. "
4.	Bloom Syndrome (Syndrome, Bloom) 08/01/2002 - "A study of the keratin 10 deficient mouse, a model for epidermolytic hyperkeratosis, and a mouse model for Bloom syndrome are reviewed in this article. "
5.	Ichthyosis (Xeroderma) 12/01/2015 - "Mutations Affecting Keratin 10 Surface-Exposed Residues Highlight the Structural Basis of Phenotypic Variation in Epidermolytic Ichthyosis." 04/01/2015 - "We previously demonstrated that mutations in keratin 10 (KRT10) cause ichthyosis with confetti (IWC), a severe dominant disorder that is characterized by progressive development of hundreds of normal skin spots via revertant mosaicism. " 01/01/2015 - "Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant negative mutations in the gene encoding keratin 10 (KRT10). " 09/01/2014 - "Early immunopathological diagnosis of ichthyosis with confetti in two sporadic cases with new mutations in keratin 10." 05/01/2014 - "Extensive postzygotic mosaicism for a novel keratin 10 mutation in epidermolytic ichthyosis."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Keratin-1
3.	Vimentin
4.	Metallothionein
5.	Betamethasone 17-Valerate (Betamethasone 17 Valerate)
6.	calcipotriene (calcipotriol)
7.	clobetasone butyrate (Eumovate)
8.	Keratin-6 (Keratin 6A)
9.	Keratins (Keratin)
10.	involucrin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)