Keratin-14 (Keratin 14)

A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.

Also Known As:

Networked: 251 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Frazer, Ian H: 4 articles (07/2015 - 11/2004)
2.	Reis-Filho, Jorge S: 4 articles (10/2013 - 08/2003)
3.	Bauer, Johann W: 4 articles (04/2013 - 12/2010)
4.	Detmar, Michael: 4 articles (11/2010 - 01/2003)
5.	Chan, Lawrence S: 4 articles (03/2010 - 09/2005)
6.	Fischer, Susan M: 3 articles (08/2013 - 05/2007)
7.	Wagner, Martin: 3 articles (04/2013 - 12/2010)
8.	Hintner, Helmut: 3 articles (04/2013 - 12/2010)
9.	Lambert, Paul F: 3 articles (01/2013 - 01/2004)
10.	Liem, Amy: 3 articles (01/2013 - 01/2004)

Related Diseases

1.	Neoplasms (Cancer) 02/15/2009 - "To study its contribution to tumor development, we overexpressed the mutant or wild-type (WT) human beta1 subunit in the basal layer of mouse epidermis using the keratin 14 promoter. " 05/01/2015 - "Analysis of human tumor specimens confirmed a significant relationship between loss of FOXA1 and increased cytokeratin 14 expression. " 02/01/2014 - "The tumors displayed an invasive growth, with positive expressions of 34betaE12, P63 and Cytokeratin 14, and negative expressions of PSA and P504s. " 12/19/2013 - "Collective invasion was led by specialized cancer cells that were defined by their expression of basal epithelial genes, such as cytokeratin-14 (K14) and p63. " 08/01/2013 - "To this end, human primary prostate tumor-derived NanogP8 was targeted to the cytokeratin 14 (K14) cellular compartment, and two lines of K14-NanogP8 mice were derived. "
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/01/2005 - "In this study, the mechanism of Keratin 14 activation in oral squamous cell carcinoma (OSCC) cell lines (HSC-2, HSC-3 and Ca9-22) was investigated. " 12/01/2005 - "Complex formations involving both SP-1 and SP-3 at the transcriptional regulatory sequence correlate with the activation of the Keratin 14 gene in human oral squamous cell carcinoma cells." 12/01/1996 - "Reproducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in transgenic mice expressing the HPV16 early-region genes, including the E6/E7 oncogenes, under the control of the human keratin-14 promoter/enhancer. " 04/01/2010 - "A novel homozygous keratin 14 mutation in a patient with autosomal recessive epidermolysis bullosa simplex and squamous cell carcinoma of the tongue." 12/01/2005 - "We have previously reported that significantly higher levels of Keratin 14 (Ker-14) was observed in oral squamous cell carcinoma (OSCC) and severely dysplastic tissues, whereas this expression was reversed in hyperplasia and in mild to moderate dysplasia. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2005 - "To study the role of HCR in psoriasis, we engineered transgenic mice with either a HCR non-risk allele or the HCR *WWCC risk allele controlled by the cytokeratin 14 promoter. " 02/15/2014 - "In the current study, we assessed IL-37 in two well-known psoriasis models: a human keratinocyte cell line (HaCaT) and the keratin 14 VEGF-A-transgenic mouse model. " 03/01/2011 - "Transgenic mice over-expressing VEGF under the Keratin 14 (K14) promoter develop an inflammatory skin condition with many of the pathobiological features of human psoriasis. " 08/01/2008 - "Transgenic keratin 14 (K14)/vascular endothelial growth factor (VEGF) mice have previously been reported to develop a psoriasis-like phenotype. " 06/01/2004 - "The expression of amphiregulin (AR) in the basal epidermis of transgenic mice [keratin 14 promoter AR gene (K14-ARGE)] has been previously shown to induce an early-onset and severe skin pathology, with many similarities to psoriasis. "
4.	Skin Diseases 07/15/2008 - "When we transferred autoreactive TCR-Tg CD8 T cells (OT-I cells), keratin 14 (K14)-mOVA(high) Tg mice developed autoreactive skin disease (graft-vs-host disease (GVHD)-like skin lesions) while K14-mOVA(low) Tg mice did not. " 10/01/2015 - "The aim of this study was to investigate the sun exposure influence on the DNA methylation profile on the matrix metalloprotease-9 (MMP9), microRNA 137 (miR-137), cytokeratin 14 (KRT14) and 19 (KRT19) genes of skin cells of subjects with no history of skin diseases. " 11/01/1998 - "Following from the observation that amphiregulin is overexpressed in lesional psoriatic epidermis, the importance of amphiregulin in hyperproliferative skin diseases has been further supported by recent studies of the targeted expression of a transgene encoding keratin 14 promoter-driven human amphiregulin to the basal epidermis of mice. " 10/01/2005 - "We have previously characterized the keratin 14 interleukin-4-transgenic (IL-4-Tg) mouse model of atopic dermatitis as a chronic pruritic inflammatory skin disease typified by skin infiltration of inflammatory cells and early up-regulation of Th2 cytokines and late surge of Th1 cytokines. " 06/28/2002 - "Mutations in the epidermal keratin genes, keratin 5 or keratin 14 lead to the disruption of keratin filament assembly, resulting in an autosomal dominant inherited blistering skin disease, epidermolysis bullosa simplex (EBS). "
5.	Carcinoma (Carcinomatosis) 07/01/2015 - "Rare to absent nuclear STAT3 expression was observed in carcinomas exhibiting moderate to intense staining for cytokeratin 14. " 10/08/2013 - "We show that formation of the actin/cytokeratin/14-3-3σ complex and cellular migration are regulated by PKCζ-dependent phosphorylation, a finding that could form the basis for intervention in aggressive breast carcinomas expressing 14-3-3σ. " 01/15/2005 - "An intermediate filament protein of basal epithelial cells, cytokeratin 14 (KRT14) was clearly differently expressed between the 3 types of carcinoma, and can be used as an aid in their differential diagnosis. " 09/15/2004 - "We performed comparative genomic hybridization (CGH) analysis on 43 grade III invasive ductal breast carcinomas positive for basal cytokeratin 14, as well as 43 grade- and age-matched CK14-negative controls, all with up to 25 years (median, 7 years) of clinical follow-up. " 09/01/2002 - "Salivary duct carcinoma: cytokeratin 14 as a marker of in-situ intraductal growth."

Related Drugs and Biologics

1.	Keratin-5 (Keratin 5)
2.	Estrogens (Estrogen)
3.	Vimentin
4.	Keratins (Keratin)
5.	Proteins (Proteins, Gene)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Keratin-19 (Keratin 19)
8.	Cadherins (E-Cadherin)
9.	Monoclonal Antibodies
10.	Progesterone Receptors (Progesterone Receptor)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Gingivectomy
4.	Drug Therapy (Chemotherapy)