Keratin-16 (Keratin 16)

A type I keratin expressed in a variety of EPITHELIUM, including the ESOPHAGUS, the TONGUE, the HAIR FOLLICLE and NAILS. Keratin-16 is normally found associated with KERATIN-6. Mutations in the gene for keratin-6 have been associated with PACHYONYCHIA CONGENITA, TYPE 1.

Also Known As:

Networked: 90 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Krueger, James G: 9 articles (01/2022 - 05/2002)
2.	Guttman-Yassky, Emma: 7 articles (01/2019 - 12/2016)
3.	Peng, Xiangyu: 5 articles (01/2019 - 12/2016)
4.	Xu, Hui: 5 articles (01/2019 - 12/2016)
5.	Estrada, Yeriel D: 4 articles (01/2019 - 12/2016)
6.	Suárez-Fariñas, Mayte: 4 articles (01/2019 - 01/2013)
7.	Garcet, Sandra: 3 articles (01/2022 - 01/2017)
8.	Zheng, Xiuzhong: 3 articles (01/2022 - 12/2016)
9.	Bissonnette, Robert: 3 articles (01/2019 - 01/2018)
10.	Coulombe, Pierre A: 3 articles (01/2019 - 11/2002)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/2016 - "Similar to classic psoriasis, KD-associated eruptions were characterized clinically by well-demarcated, scaly pink plaques and histopathologically by intraepidermal neutrophils, suprabasilar keratin 16 expression, and increased Ki-67 expression. " 01/01/2003 - "Cytokeratin 16 is expressed in hyperproliferative epidermis such as psoriasis and wound healing. " 02/01/2023 - "We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. " 11/14/2003 - "Overexpression of keratin 16 has been observed in keratinocytes in those skin diseases characterized by hyperproliferation such as psoriasis. " 03/01/2000 - "The regulation of keratinocyte differentiation is particularly important in psoriasis, and one of the markers for hyperproliferative and differentiating skin diseases is cytokeratin 16. "
2.	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome) 01/01/2018 - "Mice genetically null for keratin 16 (Krt16), one of the genes mutated in pachyonychia congenita, develop pachyonychia congenita-like PPK. " 05/01/2001 - "Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16." 10/01/1999 - "Cloning of multiple keratin 16 genes facilitates prenatal diagnosis of pachyonychia congenita type 1." 11/01/2011 - "A novel frameshift mutation in keratin 16 underlies pachyonychia congenita with focal palmoplantar keratoderma." 12/01/1999 - "Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1."
3.	Neoplasms (Cancer) 06/01/1996 - "This region is located telomeric to the keratin 16 gene, in which mutations have been identified in focal PPK families who show no increased cancer risk. " 07/31/2021 - "Previously we have shown by in silico analysis that keratin 16 (KRT16) mRNA upregulation might be associated with more aggressive cancer. " 03/01/1995 - "Relative amounts of keratin 17 are higher than those of keratin 16 in hair-follicle-derived tumors in comparison with nonfollicular epithelial skin tumors." 01/01/2019 - "Objectives: keratin 16 (KRT16) is a type I cytokeratin that overexpressed in many kinds of cancers, but unlike other keratins, KRT16 was poorly studied, so the aim of current study was to determine the biological role of KRT16 in lung adenocarcinoma (LUAD). " 09/28/2005 - "While no gene or protein was consistently over-expressed in all cancer versus BPH cell cultures, cytokeratin 16 protein was highly elevated in several of the cancer cultures, suggesting that a hyperproliferative phenotype may be characteristic of prostate cancer cells."
4.	Hyperkeratosis of the palms and soles and esophageal papillomas 05/01/2021 - "Novel keratin 16 mutation in a Chinese family with focal palmoplantar keratoderma." 01/01/2019 - "Further, we report on the novel observation that keratin 16 can localize to the nucleus of epithelial cells, implying a potential nuclear function that may be relevant to PC and FNEPPK." 06/01/2000 - "We have previously shown that mutations in keratin 16 (K16) cause fragility of specific epithelia resulting in phenotypes of PC-1 or FNEPPK alone. " 10/01/1995 - "Novel mutations in keratin 16 gene underly focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families." 11/01/2011 - "A novel frameshift mutation in keratin 16 underlies pachyonychia congenita with focal palmoplantar keratoderma."
5.	Melanoma (Melanoma, Malignant) 10/01/2009 - "However, several studies have challenged this paradigm by reporting, for example, that melanoma cells can express keratins and that normal human epidermal melanocytes, which derive from the neural crest, express keratin 16 (K16) in situ. " 10/01/2023 - "The top 10 upregulated genes included: (1) cancer susceptibility 9 (CASC9), (2) homeobox C13 (HOXC13), (3) keratin 6a (KRT6A), (4) desmoglein 3 (DSG3), (5) keratin 16 (KRT16), (6) forkhead box E1 (FOXE1), (7) preferentially expressed antigen in melanoma (PRAME), (8) calmodulin-like protein 3 (CALML3), (9) KRT68, and (10) aldo-keto reductase family 1 member B10 (AKR1B10). "

Related Drugs and Biologics

1.	Keratins (Keratin)
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Nestin
5.	Resistin
6.	Leptin
7.	S100 Calcium Binding Protein A7
8.	interleukin-21 (interleukin 21)
9.	Keratin-17 (Keratin 17)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Subcutaneous Injections