Matrix Metalloproteinase 20

A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matrix. The enzyme has a high specificity for dental enamel matrix protein AMELOGENIN.

Also Known As:

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bartlett, John D: 3 articles (12/2011 - 12/2002)
2.	Skobe, Ziedonis: 3 articles (12/2011 - 12/2002)
3.	Bartlett, J D: 2 articles (01/2008 - 08/2000)
4.	Nikai, H: 2 articles (08/2000 - 04/2000)
5.	Takata, T: 2 articles (08/2000 - 04/2000)
6.	Uchida, T: 2 articles (08/2000 - 04/2000)
7.	Wang, T: 2 articles (08/2000 - 04/2000)
8.	Zhao, M: 2 articles (08/2000 - 04/2000)
9.	Aseervatham, Jaya: 1 article (07/2020)
10.	Ogbureke, Kalu U E: 1 article (07/2020)

Related Diseases

1.	Calcifying Odontogenic Cyst 08/01/2000 - "Furthermore, enamelysin was also detected in globular amyloid masses and calcified foci in calcifying epithelial odontogenic tumors, hyaline droplets, small and large mineralized areas in adenomatoid odontogenic tumors, and a portion of ghost cells in calcifying odontogenic cysts. " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
2.	Carcinoma (Carcinomatosis) 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
3.	Amelogenesis Imperfecta 05/01/2006 - "Mutations in both the human amelogenin and human matrix metalloproteinase-20 (MMP20, enamelysin) genes cause amelogenesis imperfecta. " 07/01/2013 - "In this article, we focus on hypomaturation autosomal-recessive-type amelogenesis imperfecta (type IIA2) and describe 2 new causal Matrix metalloproteinase 20 (MMP20) mutations validated in two unrelated families: a missense mutation p.T130I at the expected homozygous state, and a compound heterozygous mutation having the same mutation combined with a nucleotide deletion, leading to a premature stop codon (p.N120fz*2). " 12/01/2011 - "Mutations of the matrix metalloproteinase 20 (MMP20, enamelysin) gene cause autosomal-recessive amelogenesis imperfecta, and Mmp20 ablated mice also have malformed dental enamel. " 01/01/2010 - "Proteolytic enzymes serve important functions during dental enamel formation, and mutations in the kallikrein 4 (KLK4) and enamelysin (MMP20) genes cause autosomal-recessive amelogenesis imperfecta (ARAI). " 01/01/2008 - "Proteolytic enzymes are necessary for the mineralization of dental enamel during development, and mutations in the kallikrein 4 (KLK4) and enamelysin (MMP20) genes cause autosomal-recessive amelogenesis imperfecta (ARAI). "
4.	Neoplasms (Cancer) 06/01/2016 - "Expression Pattern of Matrix Metalloproteinase 20 (MMP20) in Human Tumors." 08/01/2000 - "Also, enamelysin was not detected in dentin, dysplastic dentinoid hyaline matrices, and cementum that were present within the tumors examined. " 08/03/2012 - "The KCOT-1 cells were characterized by growth rate, gene expression profiles of major tooth enamel matrix proteins (EMPs), amelogenin (AMELX), enamelin (ENAM), ameloblastin (AMBN), amelotin (AMTN), tumor-related proteins enamelysin (MMP-20), kallikrein-4 (KLK-4), and odontogenic ameloblast-associated protein (ODAM) using quantitative real-time reverse transcription-polymerase chain reaction. "
5.	Wounds and Injuries (Trauma) 11/01/1999 - "MMP-20 (enamelysin) was absent and MMP-8 (collagenase-2) was rarely found in RA or trauma. "

Related Drugs and Biologics

1.	Amelogenin
2.	Proteins (Proteins, Gene)
3.	tuftelin (enamelin)
4.	Antibodies
5.	Matrix Metalloproteinase 20
6.	Peptide Hydrolases (Proteases)
7.	kallikrein 4
8.	Nonsense Codon (Nonsense Mutation)
9.	Threonine (L-Threonine)
10.	Proline (L-Proline)