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Matrix Metalloproteinase 14 (MT1-MMP)

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Also Known As:
MT1-MMP; Membrane-Type Matrix Metalloproteinase 1; MMP-14 Metalloproteinase; MMP-X1 Protein; MMP14 Metalloproteinase; MT-MMP-1; MT1-Matrix Metalloproteinase; Membrane-Type 1 Matrix Metalloproteinase; MMP 14 Metalloproteinase; MMP X1 Protein; MT1 Matrix Metalloproteinase; Membrane Type 1 Matrix Metalloproteinase; Membrane Type Matrix Metalloproteinase 1; Metalloproteinase 14, Matrix; Metalloproteinase, MMP-14; Metalloproteinase, MMP14; Metalloproteinase, MT1-Matrix
Networked: 1088 relevant articles (17 outcomes, 157 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Strongin, Alex Y: 42 articles (02/2017 - 01/2002)
2. Seiki, Motoharu: 38 articles (01/2020 - 01/2002)
3. Annabi, Borhane: 23 articles (11/2021 - 01/2002)
4. Koshikawa, Naohiko: 20 articles (01/2020 - 08/2002)
5. Sato, Hiroshi: 20 articles (08/2016 - 03/2002)
6. Chavrier, Philippe: 17 articles (01/2021 - 06/2008)
7. Rozanov, Dmitri V: 17 articles (09/2010 - 03/2002)
8. Takino, Takahisa: 16 articles (09/2021 - 10/2003)
9. Golubkov, Vladislav S: 15 articles (07/2013 - 11/2004)
10. Stack, M Sharon: 14 articles (11/2017 - 10/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Neoplasm Metastasis (Metastasis)
4. Carcinoma (Carcinomatosis)
5. Hypoxia (Hypoxemia)

Related Drugs and Biologics

1. Matrix Metalloproteinases (MMPs)
2. Tissue Inhibitor of Metalloproteinase-2
3. Proteins (Proteins, Gene)
4. Collagen
5. Metalloproteases (Metalloproteinases)
6. Amyloid (Amyloid Fibrils)
7. Lectins
8. Monomeric GTP-Binding Proteins
9. Phosphoric Monoester Hydrolases (Phosphatases)
10. Tensins

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Ligation
4. Intravenous Injections
5. Aftercare (After-Treatment)