Osteopontin

A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.

Also Known As:

Networked: 4059 relevant articles (84 outcomes, 514 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Uede, Toshimitsu: 53 articles (06/2020 - 01/2002)
2.	Denhardt, David T: 42 articles (10/2013 - 09/2000)
3.	Kuo, Paul C: 34 articles (01/2022 - 12/2003)
4.	Chambers, Ann F: 33 articles (01/2020 - 01/2002)
5.	Mi, Zhiyong: 28 articles (01/2022 - 09/2004)
6.	Rittling, Susan R: 27 articles (01/2017 - 09/2000)
7.	Kon, Shigeyuki: 26 articles (06/2020 - 01/2002)
8.	Weber, Georg F: 25 articles (10/2022 - 08/2002)
9.	Hattori, Toshio: 24 articles (08/2021 - 08/2009)
10.	Kundu, Gopal C: 23 articles (01/2021 - 04/2003)

Related Diseases

1.	Inflammation (Inflammations) 12/01/2012 - "Osteopontin (OPN) plays an important role in the initiation of inflammation, affecting cell adhesion, chemotaxis, immune regulation, and protection against apoptosis, depending on its intracellular or extracellular localization. " 01/01/2020 - "Lack of osteopontin lowered systemic inflammation, prevented HCC progression to less differentiated tumours and improved overall survival. " 11/16/2020 - "Immunohistochemical staining for inflammation (osteopontin and ED-1 staining) revealed improved interstitial inflammation in the TAC with AAT group compared to that in the TAC group. " 01/01/2019 - "Future studies of mechanisms of osteopontin's roles in acute muscle inflammation and regeneration will need to investigate responses to osteopontins derived from both myoblasts and macrophages." 08/01/2008 - "Aim of the study was to investigate the expression of OPN (osteopontin) and its upper-downstream regulating factors in the biliary atretic liver and explore the relationship to progressive intrahepatic fibro-inflammation. "
2.	Neoplasms (Cancer) 02/15/2006 - "Patients with both S100A4-positive and osteopontin-positive primary tumors showed a statistically significant reduction in survival time over those with either one alone (P < 0.019), although in multivariate regression analysis, only staining for S100A4 was significant (P < 0.001). " 05/14/2023 - "Transcriptional profiling of autophagy-deficient tumor cells and further mechanistic studies revealed a role for osteopontin (OPN) and its downstream Jak/Stat3 signaling in mediating regulation of vascular tumor cells by autophagy. " 07/01/2022 - "Objective of the study was to evaluate the diagnostic test characteristics of plasma osteopontin (OPN) in detecting ovarian malignancy and comparing its performance with CA125. " 01/01/2020 - "Collectively, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumor-osteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment." 01/01/2018 - "The purpose of this study was to determine whether osteopontin could be useful in differential diagnosis of ovarian tumors. "
3.	Fibrosis (Cirrhosis) 01/01/2020 - "The current study aimed to investigate liver stiffness and its correlation with the expression of the transcriptional coactivator with PDZ-binding motif (TAZ) and serum osteopontin (OPN) in human cirrhosis. " 09/01/2014 - "Being a human study, there was no control group, so it is not possible to determine the contribution of osteopontin in the formation of epidural fibrosis and its relation to the patients' symptoms. " 11/01/2012 - "Our previous study found that osteopontin (OPN) increased in plasma of cirrhotic patients and indicative of cirrhosis staging. " 09/01/2005 - "To study the fibrosis-relevant effects of osteopontin we stimulated primary human lung fibroblasts and alveolar epithelial cells (A549) with recombinant osteopontin. " 06/01/2004 - "Recent gene microarray studies found that osteopontin is abundantly expressed in both human and mouse lung fibrosis. "
4.	Breast Neoplasms (Breast Cancer) 12/01/2013 - "The expression of osteopontin-c was an independent prognostic factor for both disease-free and overall survival of breast cancer patients. " 01/15/2020 - "1,2,3-Triazole tethered 1,2,4-trioxanes: Studies on their synthesis and effect on osteopontin expression in MDA-MB-435 breast cancer cells." 01/01/2017 - "Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group." 01/01/2016 - "This study aimed to investigate the expression of osteopontin (OPN), p2lras, and CD44V6 in breast cancer tissues, and to analyze the relationships between their expression and a patient's clinicopathological characteristics and five-year survival rate. " 01/22/2014 - "Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial."
5.	Chronic Hepatitis C 06/01/2014 - "Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication." 04/01/2005 - "Extrahepatic manifestations in transgenic mice of osteopontin in hepatocytes-A clue to advent of pathological state in various organs of chronic hepatitis C patients." 12/01/2012 - "Elevated serum osteopontin levels in chronic hepatitis C virus infection: association with autoimmune rheumatologic manifestations." 01/23/2004 - "Genetic polymorphims in promoter region of osteopontin gene may be a marker reflecting hepatitis activity in chronic hepatitis C patients." 12/01/2012 - "Owing to the suggested role of osteopontin (OPN) in inflammation, autoimmunity and fibrosis, we investigated their serum concentrations in chronic hepatitis C virus (HCV) infected patients with and without autoimmune manifestations and correlated those levels to clinical manifestations and the histological severity of hepatic fibrosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Biomarkers (Surrogate Marker)
3.	Cytokines
4.	Osteoprotegerin
5.	Interferons
6.	Integrin-Binding Sialoprotein
7.	alpha-Fetoproteins (alpha-Fetoprotein)
8.	Interleukin-6 (Interleukin 6)
9.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
10.	Lipocalin-2

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Renal Dialysis (Hemodialysis)