Peptides derived from pro-opiomelanocortin (POMC) which can stimulate MELANOCYTES or CORTICOTROPHS. Melanocortins include ACTH; ALPHA-MSH; and other peptides such as BETA-MSH and GAMMA-MSH, derived from other fragments of POMC. These peptides act through a variety of MELANOCORTIN RECEPTORS to control different functions including steroidogenesis, energy homeostasis, feeding, and skin pigmentation.
Networked: 122 relevant articles (6 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Guarini, Salvatore: 23 articles (12/2015 - 01/2002)
2. Giuliani, Daniela: 21 articles (12/2015 - 08/2002)
3. Ottani, Alessandra: 16 articles (12/2015 - 09/2007)
4. Squadrito, Francesco: 13 articles (03/2014 - 11/2005)
5. Zaffe, Davide: 12 articles (07/2015 - 11/2005)
6. Galantucci, Maria: 12 articles (03/2014 - 05/2006)
7. Bitto, Alessandra: 12 articles (03/2014 - 11/2005)
8. Altavilla, Domenica: 12 articles (03/2014 - 11/2005)
9. Minutoli, Letteria: 11 articles (04/2012 - 11/2005)
10. Bertolini, Alfio: 9 articles (12/2015 - 01/2002)

Related Diseases

1. Inflammation
2. Shock
3. Myocardial Ischemia (Ischemic Heart Diseases)
4. Stroke (Strokes)
5. Ischemia
02/01/2013 - "On the other hand, concurrent animal and human data show that melanocortin peptides with agonist activity at melanocortin MC3/MC4 receptors are highly effective in different shock conditions as well as in conditions of ischemia/ischemia-reperfusion of individual organs (heart, brain, intestine, kidney, etc.), and accumulating evidence indicates that such effects of melanocortins are mostly due to quite peculiar antiinflammatory mechanisms. "
12/01/2015 - "Our aim was (i) to critically reconsider the established extrahormonal effects of melanocortins (on sexual activity, feeding, inflammation, tissue hypoperfusion, and traumatic damage of central and peripheral nervous system) at the light of recent findings, (ii) to review the most recent advancements, particularly on the effects of melanocortins in models of neurodegenerative diseases, (iii) to discuss the reasons that support the introduction into clinical practice of melanocortins as life-saving agents in shock conditions and that suggest to verify in clinical setting the impressive results steadily obtained with melanocortins in different animal models of tissue ischemia and ischemia/reperfusion, and finally, (iv) to mention the advisable developments, particularly in terms of selectivity of action and of effects. "
12/01/2015 - "Moreover, a large body of animal data, some of which were also confirmed in humans, unequivocally show that melanocortins also have impressive therapeutic effects in several pathological conditions that are the leading cause of mortality and disability worldwide (hemorrhagic, or anyway hypovolemic, shock; septic shock; respiratory arrest; cardiac arrest; ischemia- and ischemia/reperfusion-induced damage of the brain, heart, intestine, and other organs; traumatic injury of brain, spinal cord, and peripheral nerves; neuropathic pain; toxic neuropathies; gouty arthritis; etc.). "
01/01/2009 - "The discovery of melanocortin receptors, and the ensuing synthesis of selective ligands with agonist or antagonist activity, is generating completely innovative drugs for the treatment of a potentially very long list of important and widespread pathological conditions: sexual impotence, frigidity, overweight/obesity, anorexia, cachexia, haemorrhagic shock, other forms of shock, myocardial infarction, ischemia/reperfusion-induced brain damage, neuropathic pain, rheumathoid arthritis, inflammatory bowel disease, nerve injury, toxic neuropathies, diabetic neuropathy, etc. This review recalls the history of these researches and outlines the pharmacology of the extra-hormonal effects of melanocortins which are produced by an action at the brain level (or mainly at the brain level). "

Related Drugs and Biologics

1. Peptides
2. Melanocortin Receptors (Melanocortin Receptor)
3. Pro-Opiomelanocortin (Proopiomelanocortin)
4. Melanocyte-Stimulating Hormones (MSH)
5. Hormones
6. Nerve Growth Factors (Neurotrophins)
7. Formaldehyde (Formol)
8. Dopamine (Intropin)
9. alpha-MSH
10. Leptin

Related Therapies and Procedures

1. Ligation
2. Cardiopulmonary Resuscitation (CPR)
3. Homologous Transplantation (Allograft)