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RecQ Helicases

Subscribe to New Research on RecQ Helicases

A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.

Also Known As:

ATP-Dependent DNA Helicase Q1; ATP-Dependent DNA Helicase Q4; ATP-Dependent DNA Helicase Q5; DNA Helicase Q1; DNA Helicase RecQL; DNA Helicase RecQL4; DNA Helicase, RecQ-like type 2; DNA-Dependent ATPase Q1; RECQL1 Helicase; RTS Helicase; RecQ Family of DNA Helicases; RecQ Protein; RecQ2 Helicase; RecQ3 Helicase; RecQ4 Helicase; RecQ5 Helicase; RecQ5L Helicase; RecQL Helicase; RecQL2 Helicase; RecQL3 Helicase; RecQL4 Helicase; ATP Dependent DNA Helicase Q1; ATP Dependent DNA Helicase Q4; ATP Dependent DNA Helicase Q5; DNA Dependent ATPase Q1; DNA Helicase, RecQ like type 2; Helicase, RECQL1; Helicase, RTS; Helicase, RecQ2; Helicase, RecQ3; Helicase, RecQ5; Helicase, RecQ5L; Helicase, RecQL; Helicase, RecQL2; Helicase, RecQL3; Helicase, RecQL4; Helicases, RecQ

Networked: 169 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 6439
        RecQ Helicases: 169
        Bloom syndrome protein: 25
        human WRN protein: 1
        Arabidopsis RecQsim protein
        Drosophila RecQ5 protein
        E coli RecQ protein
        human RECQL protein
        human RECQL4 protein
        human RECQL5 protein
        mouse Recql5 protein
        mouse Wrn protein
        S cerevisiae SGS1 protein
        DNA Helicases: 86
        RecQ Helicases: 169
        Bloom syndrome protein: 25
        human WRN protein: 1
        Arabidopsis RecQsim protein
        Drosophila RecQ5 protein
        E coli RecQ protein
        human RECQL protein
        human RECQL4 protein
        human RECQL5 protein
        mouse Recql5 protein
        mouse Wrn protein
        S cerevisiae SGS1 protein
  - Isomerases: 29
    - DNA Helicases: 86
      - RecQ Helicases: 169
        Bloom syndrome protein: 25
        human WRN protein: 1
        Arabidopsis RecQsim protein
        Drosophila RecQ5 protein
        E coli RecQ protein
        human RECQL protein
        human RECQL4 protein
        human RECQL5 protein
        mouse Recql5 protein
        mouse Wrn protein
        S cerevisiae SGS1 protein

Experts

1.	Bohr, Vilhelm A: 18 articles (11/2014 - 11/2003)
2.	Brosh, Robert M: 15 articles (11/2015 - 01/2004)
3.	Sharma, Sudha: 12 articles (06/2015 - 05/2005)
4.	Hickson, Ian D: 10 articles (01/2013 - 11/2002)
5.	Croteau, Deborah L: 9 articles (11/2014 - 09/2009)
6.	Vindigni, Alessandro: 9 articles (07/2013 - 01/2004)
7.	Popuri, Venkateswarlu: 6 articles (01/2014 - 02/2007)
8.	Furuichi, Yasuhiro: 6 articles (05/2012 - 08/2004)
9.	Shimamoto, Akira: 6 articles (06/2008 - 08/2004)
10.	Hickson, I D: 6 articles (09/2007 - 02/2000)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2007 - "A number of studies have described interactions of RecQ helicases with topoisomerases and it has been proposed that this cooperation may be essential for cell viability and the avoidance of cancer development in human cells." 05/01/2014 - "Mice deficient in RecQL5, one of five RecQ helicases, show a cancer predisposition phenotype, suggesting that RecQL5 plays a tumor suppressor role. " 01/01/2014 - "The "tumor suppressor" role of RECQL4 and the other RECQ helicases is an area of active investigation. " 08/01/2012 - "Humans have five different RecQ helicases and defects in three of them cause autosomal recessive diseases leading to various kinds of cancer predisposition and/or aging phenotypes. " 01/01/2011 - "In future, RecQ helicases are anticipated to be additional molecular targets for cancer chemotherapeutics."
2.	Werner Syndrome (Werner's Syndrome) 07/01/2010 - "Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations at the WRN locus, which codes for a member of the RecQ family of DNA helicases. " 01/01/2008 - "Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases." 09/07/2007 - "We show here that the Werner syndrome protein (WRN), a member of the RecQ family of DNA helicases, associates with NEIL1 in the early damage-sensing step of base excision repair. " 09/15/2005 - "Werner syndrome is an autosomal recessive accelerated-aging disorder caused by a defect in the WRN gene, which encodes a member of the RecQ family of DNA helicases with an exonuclease activity. " 02/25/2005 - "The prototypic example of the former is the Werner syndrome, a condition caused by mutations of the RecQ family of DNA helicases. "
3.	Chromosomal Instability (Chromosome Stability) 04/15/2008 - "Collectively, these studies provide the first evidence for an important role of RECQ1 to confer chromosomal stability that is unique from that of other RecQ helicases and suggest its potential involvement in tumorigenesis." 03/01/2007 - "RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability." 02/01/2007 - "RecQ helicases are essential for the maintenance of chromosome stability. " 09/01/2009 - "Genetic defects in three of the five human RecQ helicases, BLM, WRN and RECQ4, give rise to defined syndromes associated with cancer predisposition, some features of premature ageing and chromosomal instability. " 12/01/2009 - "RecQ helicases maintain chromosome stability by resolving several highly specific DNA structures. "
4.	Genomic Instability 08/14/2015 - "Fission yeast Rqh1 is a member of RecQ helicases family which has essential roles in the maintenance of genomic stability and regulation of homologous recombination. " 01/01/2015 - "Like other RECQ helicases, WRN/RECQL2 plays a crucial role in DNA replication and the maintenance of genome stability. " 08/01/2014 - "Together, our data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases. " 02/01/2014 - "RecQ helicases are critical for the maintenance of genomic stability. " 01/01/2014 - "Future research goals in this field include a better understanding of the division of labor among the human RecQ helicases and learning how human RecQ helicases collaborate and cooperate to enhance genome stability. "
5.	Premature Aging 09/01/2007 - "Defects in RecQ helicases result in premature aging phenotypes in both yeasts and humans, which appear to be promoted by replicative stress. " 01/01/2007 - "Human premature aging, DNA repair and RecQ helicases." 09/15/2003 - "RecQ helicases: suppressors of tumorigenesis and premature aging." 11/01/2012 - "RecQL4, one of the five human RecQ helicases, is crucial for genomic stability and RecQL4 when mutated leads to premature aging phenotypes in humans. " 03/02/2010 - "Defects in three of the RecQ helicases, RecQ4, BLM, and WRN, cause human pathologies linked with cancer predisposition and premature aging. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	DNA Glycosylases (DNA Glycosylase)
3.	A-Form DNA (A-DNA)
4.	Deoxyribonuclease (Pyrimidine Dimer)
5.	Pyrimidines
6.	Purines
7.	5-hydroxyuracil
8.	5-hydroxycytosine
9.	Proteins (Proteins, Gene)
10.	DNA Helicases

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Drug Therapy (Chemotherapy)