Initiator Caspases

A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.

Also Known As:

Networked: 34 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Salvesen, Guy S: 2 articles (06/2011 - 12/2006)
2.	Baena-Lopez, Luis Alberto: 1 article (01/2022)
3.	Wang, Li: 1 article (01/2022)
4.	Xu, Derek Cui: 1 article (01/2022)
5.	Yamada, Kenneth M: 1 article (01/2022)
6.	Atkins, Coleen M: 1 article (01/2020)
7.	Boucher, Dave: 1 article (01/2020)
8.	Broz, Petr: 1 article (01/2020)
9.	Bullock, Ross: 1 article (01/2020)
10.	Chen, Kaiwen W: 1 article (01/2020)

Related Diseases

1.	Liver Diseases (Liver Disease) 02/01/2000 - "Therapies targeting the death receptors, initiator caspases and mitochondria show potential promise in various liver disease, whereas targeting inhibition of executioner caspases may rapidly or in delayed fashion switch from apoptotic to necrotic cell death."
2.	Neoplasms (Cancer) 01/01/2022 - "Our data indicate that widespread non-apoptotic activation of initiator caspases limits JNK signaling and facilitates cell fate commitment in these tumors, thus preventing the overgrowth and exacerbation of malignant features of transformed cells. " 10/01/2012 - "Tumor size time series data from rodent tumor xenograft (COLO205) studies following administration of either of these two pro-apoptotic receptor agonists (PARAs) were combined to develop a intracellular-signaling tumor-regression model that includes two levels of signaling: upstream signals unique to each compound (representing initiator caspases), and a common downstream apoptosis signal (representing executioner caspases) shared by the two agents. " 11/24/2010 - "There is experimental evidence from transgenic mice that certain initiator caspases, such as caspase-8 and -2, might act as tumor suppressors. " 11/24/2010 - "Executioner caspases have only rarely been found mutated or silenced, and also initiator caspases are only affected in particular types of cancer. " 03/01/2014 - "We have recently reported that Ginsenoside Rh2 (G-Rh2) induces the activation of two initiator caspases, caspase-8 and caspase-9 in human cancer cells. "
3.	Carcinoma (Carcinomatosis) 10/01/2019 - "To better understand the cell death signaling induced by radiation, the immortalized mouse embryonic fibroblast (MEF) deficient in "initiator" caspases, "effector" caspases or different Bcl-2 family proteins together with human colon carcinoma cell HCT116 were used. " 09/01/2007 - "Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked apoptosis-mediated cytotoxic effects in human cancer cells but not in normal fibroblasts by triggering the activation of the initiator caspases of the death receptor pathway (caspase-8 and caspase-10) at least in human MCF-7 breast and PC-3 prostate carcinoma cells. "
4.	Infections 08/01/2005 - "Induction of apoptosis during Sendai virus (SeV) infection has previously been documented to be triggered by initiator caspases (for strain F) or by a contribution of the cellular protein TIAR (T-cell-activated intracellular antigen-related) (for strain Z). " 01/01/2023 - "Infection with higher neurovirulent strain resulted in higher upregulation of pro-apoptotic proteins including death receptors (DR), adaptor protein, BH3-only regulatory proteins and higher cleavage of initiator caspases of both pathways. " 10/01/2010 - "Furthermore, TCDD was able to trigger BHV-1-induced apoptosis by up-regulating the activation of initiator caspases 8 and 9, as well as of effector caspase 3. Since TCDD activates caspase 3 after 4 h of infection, we have hypothesized an involvement of BHV-1 infected cell protein 0 (bICP0) in this process. " 12/01/2007 - "arMP-12-del21/384 replication triggered apoptosis, including the cleavage of caspase-3, the cleavage of its downstream substrate, poly(ADP-ribose) polymerase, and activation of the initiator caspases, caspase-8 and -9, earlier in infection than arMP-12. " 04/01/2005 - "An analysis of caspase activity, using fluorometric caspase assays and Western blots, indicated that each of the main initiator caspases, caspase-8, caspase-9, and caspase-12, were activated during infection with the rM51R-M virus. "
5.	Coronavirus Infections 09/01/2013 - "Moreover, as is commonly observed for coronavirus infections of other animals, the activities of the effecter caspase, caspase-3, and the initiator caspases, caspase-8 and caspase-9, which are representative factors in the death receptor-mediated apoptotic pathway and the mitochondrial apoptotic pathway, respectively, were increased in PHEV-infected PK-15 cells. " 06/22/2008 - "Moreover, as is commonly observed in coronavirus infection in other animals, the activities of effecter caspases - caspase-3/7 - and initiator caspases - caspase-8 and caspase-9 - that are representative factors in the death receptor-mediated apoptotic pathway and mitochondrial apoptotic pathway, respectively, were increased in ECoV-infected MDBK cells. "

Related Drugs and Biologics

1.	Caspases
2.	Death Domain Receptors
3.	narciclasine
4.	isocarbostyril
5.	Caspase 3 (Caspase-3)
6.	Caspase 8 (Caspase-8)
7.	Caspase 9
8.	Proteins (Proteins, Gene)
9.	Effector Caspases
10.	Inflammasomes

Related Therapies and Procedures

1.	Therapeutics