Effector Caspases

A subclass of caspases that contain short pro-domain regions. They are activated by the proteolytic action of INITIATOR CASPASES. Once activated they cleave a variety of substrates that cause APOPTOSIS.

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Networked: 71 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Means, John C: 2 articles (03/2014 - 05/2010)
2.	Passarelli, A Lorena: 2 articles (03/2014 - 05/2010)
3.	Antunes, Lusânia Maria Greggi: 1 article (04/2022)
4.	Cólus, Ilce Mara de Syllos: 1 article (04/2022)
5.	Gomes, Izabela Natalia Faria: 1 article (04/2022)
6.	Lengert, André van Helvoort: 1 article (04/2022)
7.	Oliveira, Larissa Cristina Bastos de: 1 article (04/2022)
8.	Reis, Rui Manuel: 1 article (04/2022)
9.	Ribeiro, Diego Luis: 1 article (04/2022)
10.	Rocha, Cláudia Quintino da: 1 article (04/2022)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 03/15/2001 - "In this study, we evaluated the safety and efficacy of a novel suicide gene therapy that could potentially spare normal tissue while bypassing molecular mechanisms of apoptosis resistance by using chemically inducible effector caspases to trigger apoptosis in prostate cancer cells. "
2.	Neoplasms (Cancer) 03/01/2016 - "Furthermore, this review illustrates the importance of new studies in the ongoing investigation into the role of effector caspases in VM, invasion, and migration of aggressive tumor cells. " 01/01/2023 - "In addition to RasV12 larvae, we included a tumor model where the activation of effector caspases was inhibited, mimicking an apoptosis-resistant setting. " 03/01/2016 - "Effector caspases are well known for their apoptotic function, whereas a non-apoptotic function in tumor progression is highly disputed. " 01/01/2011 - "effector caspases and the p53 tumor suppressor. " 03/15/2000 - "The identification of the critical elements of drug-induced apoptosis and activation of effector caspases will certainly provide new insights into the molecular determinants of chemosensitivity or chemoresistance of malignant tumors and leukemias."
3.	Infections 10/01/2001 - "In the present study, we measured the activation of effector caspases in liver biopsy specimens of patients with chronic HCV infection. " 01/01/2019 - "Moreover, the activation of effector caspases and the presence of cellular apoptotic/necrotic changes were evaluated at different time points after CT infection. " 08/01/2008 - "Although related, P49 and P35 inhibit initiator and effector caspases, respectively, during infection of permissive insect cells. " 08/15/2005 - "The ability to modulate the activity of effector caspases may therefore represent an unexploited avenue for therapeutic intervention in GBS infections." 12/15/2015 - "DCV infection killed flies in a dose-responding manner, and the activation of effector caspases was evident, as revealed by the cleavage of a target protein ectopically expressed in flies. "
4.	Melanoma (Melanoma, Malignant) 11/15/2000 - "In the present studies we have examined whether TRAIL-induced apoptosis of melanoma was mediated by direct activation of effector caspases or whether apoptosis was dependent on changes in mitochondrial membrane potential (MMP) and mitochondrial-dependent pathways of apoptosis. " 03/01/2007 - "Cytochrome c release into cytosol, and the activation of effector caspases, estimated by PARP degradation clearly showed that during the spontaneous death in the cells from both melanoma lines intrinsic way of apoptosis was activated. " 01/26/2016 - "This was shown by extensive drug interaction analysis, tumor growth inhibition assays in-vivo, p-ERK and p-AKT inhibition, promotion of melanoma apoptosis, apoptosis-related protein modulation, activation of effector caspases and selective modulation of genes involved in melanoma drug resistance and belonging to the ERK/MAPK and PI3K/AKT canonical pathways. " 07/14/2011 - "Activation of effector caspases, chromatin condensation and DNA degradation, suggested that C7a activates the apoptotic intrinsic pathway in murine melanoma cells. " 12/01/2016 - "Such effect involved the activation of several caspases including (iii) initiator caspases 8, 9, 4 (indicating the involvement of intrinsic, extrinsic and endoplasmic reticulum-based pathways) and (iv) effector caspases 3, 7 and 6. Utilization of low isothiocyanate concentrations (under the conditions described herein) exerts an anti-cancer effect specific to human malignant melanoma cells thus providing a therapeutic basis for their utilization in management of the disease."
5.	Stomach Neoplasms (Stomach Cancer) 11/01/2002 - "Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study."

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Caspase 7
3.	Transcription Factors (Transcription Factor)
4.	Cathepsin L
5.	Prohibitins
6.	Proteins (Proteins, Gene)
7.	Caspases
8.	Caspase 3 (Caspase-3)
9.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
10.	Caspase 8 (Caspase-8)