Caspase 12

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 12 is activated by pro-apoptotic factors that are released during cell stress and by CARD SIGNALING ADAPTOR PROTEINS. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.

Also Known As:

Networked: 157 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saleh, Maya: 8 articles (01/2016 - 05/2004)
2.	Han, Fang: 5 articles (08/2015 - 01/2013)
3.	Nicholson, Donald W: 4 articles (06/2009 - 05/2004)
4.	Chien, Chiang-Ting: 3 articles (01/2015 - 01/2010)
5.	Wang, Sheue-Er: 3 articles (01/2015 - 01/2015)
6.	Lin, Ching-Lung: 3 articles (01/2015 - 01/2015)
7.	Sheu, Shuenn-Jyi: 3 articles (01/2015 - 01/2015)
8.	Hsu, Chih-Hsiang: 3 articles (01/2015 - 01/2015)
9.	Wu, Chung-Hsin: 3 articles (01/2015 - 01/2015)
10.	Shi, Yuxiu: 3 articles (01/2014 - 07/2013)

Related Diseases

1.	Cardiomyopathies (Cardiomyopathy) 01/01/2015 - "Shengmai injection improved doxorubicin-induced cardiomyopathy by alleviating myocardial endoplasmic reticulum stress and caspase-12 dependent apoptosis." 02/01/2008 - "This reduced not only the increase of cleaved caspase-12 but also of the number of myocyte apoptosis produced by beta(1)-EC(II) IgG. Thus, we conclude that ER stress plays an important role in cell death and cardiac dysfunction in beta(1)-EC(II) IgG cardiomyopathy, and the effects of beta(1)-EC(II) IgG are mediated via the beta(1)-adrenergic receptor."
2.	Colitis 03/01/2015 - "Finally, fexofenadine significantly reduced the severity of colitis and the immunoreactivity of caspase-12 and p-eIF2-α in IL-10(-/-) mice as compared with controls. "
3.	Post-Traumatic Stress Disorders (PTSD) 08/01/2015 - "In conclusion, the findings of the present study suggested that SPS induced GRP78 and caspase 12 upregulation and morphological changes of the ER in the amygdala, which may play important roles in the pathogenesis of PTSD rats." 08/01/2015 - "The aim of the present study, was to investigate the involvement of the endoplasmic reticulum (ER) in post-traumatic stress disorder (PTSD) by detecting changes of ER chaperone protein 78 and ER-resident caspase 12 in the basolateral amygdala after exposure to single prolonged stress (SPS). " 01/01/2013 - "SPS induced change in the expression levels of GRP78, caspase-12 and Ca(2+)/CaM/CaMkIIα in the hippocampus of PTSD rats indicated that the endoplasmic reticulum pathway may be involved in PTSD-induced apoptosis." 01/01/2014 - "The objective of this study was to investigate the change of the glucose-regulated protein (GRP) 94 and apoptosis-related caspase-12 expression in medial prefrontal cortex (mPFC) in rats to determine whether endoplasmic reticulum apoptosis pathway plays an important role in single-prolonged stress (SPS), a well-established PTSD animal model, and therefore to provide experimental evidence to reveal PTSD pathogenesis. " 01/01/2013 - "The aim of this study was to investigate whether endoplasmic reticulum-related pathway is involved in single-prolonged stress (SPS) induces apoptosis in the hippocampus of PTSD rats by examining the expression levels of three important indicators in the ER-related apoptotic pathway: Glucose-regulated protein (GRP) 78, caspase-12 and Ca(2+)/CaM/CaMkinaseIIα (CaMkIIα). "
4.	Sepsis (Septicemia) 01/01/2014 - "Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. " 03/01/2012 - "Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients." 03/01/2012 - "African-American Candida sepsis patients (n = 93) and non-infected African-American patients (n = 88) were genotyped for the CASPASE-12 genotype. " 03/01/2012 - "Here, we have assessed the frequencies of both CASPASE-12 alleles in an African-American Candida sepsis patients cohort compared to uninfected patients with similar predisposing factors. " 03/01/2012 - "Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a susceptibility factor for bacterial sepsis. "
5.	Anoxia (Hypoxia) 10/25/2006 - "Using primary cultured neonatal cardiomyocytes, CRT and caspase-12 expression and activation during hypoxic preconditioning (HPC) and hypoxia/reoxygenation (H/R) were studied to explore the role of ERS in cardioprotection by HPC. " 11/01/2005 - "We found that hypoxia induced ER stress, as assessed by the expression of CHOP and BiP and cleavage of caspase 12. " 06/01/2015 - "At later stages, chemical hypoxia increased the expression of the C/EBP homologous protein (CHOP) and caspase 12 activity. " 08/01/2012 - "We found that taurine suppresses the up-regulation of caspase-12 and GADD153/CHOP induced by hypoxia/reoxygenation, suggesting that taurine may exert a protective function against hypoxia/reoxygenation by reducing the ER stress. " 06/01/2012 - "Stage 3 samples had increase caspase 7 and caspase 12 activities compared to stage 2 samples, and by Western blotting protein levels of both HSP70 and HSP90 expressions, increased significantly under hypoxia condition (*p < 0.05). "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	fexofenadine (Allegra)
3.	Glucose (Dextrose)
4.	Molecular Chaperones (Chaperone, Molecular)
5.	Caspase 3 (Caspase-3)
6.	Caspase 9
7.	Calreticulin
8.	Oxygen
9.	Calmodulin (Calcium-Dependent Activator Protein)
10.	Transcription Factor CHOP

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Subcutaneous Injections
3.	Intraperitoneal Injections