Caspase 9

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.

Also Known As:

Networked: 1110 relevant articles (19 outcomes, 98 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Delivoria-Papadopoulos, Maria: 13 articles (08/2012 - 07/2004)
2.	Mishra, Om P: 12 articles (08/2010 - 07/2004)
3.	Ashraf, Qazi M: 8 articles (12/2008 - 03/2007)
4.	Kim, Sung-Hoon: 7 articles (07/2015 - 10/2004)
5.	Schulze-Osthoff, Klaus: 7 articles (04/2012 - 10/2006)
6.	Dent, Paul: 6 articles (10/2013 - 05/2002)
7.	Chung, Jing-Gung: 6 articles (10/2013 - 01/2009)
8.	Grant, Steven: 5 articles (10/2013 - 05/2002)
9.	Yang, Jai-Sing: 5 articles (09/2012 - 01/2009)
10.	Wang, Shaomeng: 5 articles (05/2012 - 05/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "We assessed published studies of the association between caspase 9 polymorphisms and cancer risk from nine studies with 5,528 subjects for rs4645978, six studies with 2,403 subjects for rs105276 and two studies for rs4645981. " 05/01/2004 - "The aim of this study was to identify extrinsic and intrinsic tumor-induced apoptotic pathways in DC by targeting different anti-apoptotic molecules, including FLIP, XIAP/hILP, dominant-negative procaspase-9 and HSP70. " 01/01/2015 - "Therefore, a deep understanding on the roles as well as regulators of caspase-9 is required to find more effective ways to conquer apoptosis-related diseases especially cancer." 01/01/2015 - "Caspase-9 as a therapeutic target for treating cancer." 12/28/2014 - "Moreover, SKLB316 could induce cancer cell apoptosis, which was associated with activation of caspase 9, downregulation of Bcl-2 and upregulation of Bax. "
2.	Ischemia 04/05/2002 - "In the present study, performed in the isolated rat heart exposed either to ischemia alone or ischemia followed by reperfusion, cleavage of caspase-9 was observed primarily in endothelial cells. " 03/01/2012 - "Thirty minutes and 24 h preconditioning with rhEPO (1,000 IU/kg) increased Bcl-xL/Bax ratio and reduced caspase-9 activity, and the same effect was observed when higher dose was given 24 h before ischemia. " 05/21/2010 - "Moreover, GRP78, caspase-9 and TUNEL cells emerge one after another during ischemia. " 09/01/2009 - "Herba Erigerontis Breviscapi Injection intervention could decrease the rate of apoptotic cells and the contents of caspase-9 and AIF in cytoplasm and serum as compared with those in the ischemia-reperfusion group, and the effects appeared after 1 h reperfusion. " 03/14/2003 - "Hu-Bcl-2 overexpression delays the activation of the cell death molecular machinery but does not control the ischemia-induced change in procaspase 9 L and S. "
3.	Anoxia (Hypoxia) 01/01/2013 - "Our study investigated the apoptotic mechanism of rat cortical neurons following hypoxia/reperfusion induced endoplasmic reticulum stress (ERS) in vitro and to explore the effect of caspase-9 inhibition on ERS induced apoptosis. " 12/05/2008 - "The results of this study demonstrate that caspase-9, a key protein in hypoxia induced apoptosis, is phosphorylated at the Ser(196) site during hypoxia. " 01/01/2013 - "These results demonstrated that ERS is involved in the neuronal apoptosis following in vitro hypoxia/reperfusion, and caspase-9 inhibition can depress the ERS induced apoptosis of neurons. " 01/01/2013 - "Following pre-treatment with caspase-9 inhibitor, the number of apoptotic cells was significantly reduced following hypoxia for 6 and reperfusion for 24 h or 48 h (P < 0.05). " 01/01/2013 - "Moreover, Ntn-1 decreased the increase of hypoxia-induced Bax, cleaved caspase-9, and -3, but blocked the decrease of hypoxia-reduced Bcl-2. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "The fused TAT-DV1-BH3 polypeptide colocalized with mitochondria and exhibited a proapoptotic effect through the regulation of caspase-9 and -3. Furthermore, the fused TAT-DV1-BH3 polypeptide suppressed the migration and invasion of the highly metastatic breast cancer cell line MDA-MB-231 in a concentration-dependent manner. " 01/01/2015 - "Enterocarpam-III induces human liver and breast cancer cell apoptosis via mitochondrial and caspase-9 activation." 10/01/2012 - "Caspase 9 promoter polymorphisms confer increased susceptibility to breast cancer." 01/23/2009 - "The protein expression levels of the active forms of caspase-9 and Bax in breast cancer cells were significantly increased by treatment with PR metabolites. " 05/01/2010 - "Recently, several studies have reported that OPN enhances chemoresistance in small-cell lung cancer and breast cancer by blocking caspase-9 and caspase-3-dependent cell apoptosis. "
5.	Carcinoma (Carcinomatosis) 04/01/2007 - "The aim of this study was to explore whether phosphorylated caspase-9 (p-caspase-9) expression could be a characteristic of gastric carcinomas. " 08/15/2010 - "Caspase-9 may be an independent prognosticator in colon carcinoma." 04/01/2007 - "Taken together, these results indicate that caspase-9 is frequently phosphorylated in gastric carcinomas, and that the phosphorylation of caspase-9 might be an inhibitory mechanism of caspase-9-mediated apoptosis in gastric carcinomas. " 04/01/2007 - "Expression of phosphorylated caspase-9 in gastric carcinomas." 04/01/2006 - "Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas."

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Cytochromes c (Cytochrome c)
3.	Caspase 8 (Caspase-8)
4.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
5.	Proteins (Proteins, Gene)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	benzyloxycarbonyl- leucyl- glutamyl- histidyl- aspartic acid fluoromethyl ketone
8.	Messenger RNA (mRNA)
9.	Glucose (Dextrose)
10.	Caspases

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Diet Therapy (Therapy, Diet)
4.	Aftercare (After-Treatment)
5.	Electroacupuncture