CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)

An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.

Also Known As:

FLIP-S; Casper Protein; FLICE-Inhibitory Protein; FLICE-Inhibitory Protein Long Form; FLICE-Inhibitory Protein Short Form; FLIP (Cellular); FLIP-L; FLIP-L Protein; FLIP-S Protein; CASP8 and FADD Like Apoptosis Regulating Protein; FLICE Inhibitory Protein; FLICE Inhibitory Protein Long Form; FLICE Inhibitory Protein Short Form; FLIP L Protein; FLIP S Protein

Networked: 225 relevant articles (4 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        CASP8 and FADD-Like Apoptosis Regulating Protein: 225
        human CFLAR protein
        mouse Cflar protein
        rat CFLAR protein
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        CASP8 and FADD-Like Apoptosis Regulating Protein: 225
        human CFLAR protein
        mouse Cflar protein
        rat CFLAR protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        CASP8 and FADD-Like Apoptosis Regulating Protein: 225
        human CFLAR protein
        mouse Cflar protein
        rat CFLAR protein
    - Signal Transducing Adaptor Proteins
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins: 44
        CASP8 and FADD-Like Apoptosis Regulating Protein: 225
        human CFLAR protein
        mouse Cflar protein
        rat CFLAR protein
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        CASP8 and FADD-Like Apoptosis Regulating Protein: 225
        human CFLAR protein
        mouse Cflar protein
        rat CFLAR protein

Experts

1.	Longley, Daniel B: 8 articles (01/2022 - 05/2007)
2.	Kwon, Taeg Kyu: 8 articles (04/2021 - 08/2010)
3.	Dent, Paul: 6 articles (01/2020 - 09/2008)
4.	Safa, Ahmad R: 6 articles (01/2019 - 05/2006)
5.	Liu, Xiangguo: 6 articles (08/2016 - 12/2006)
6.	Johnston, Patrick G: 5 articles (01/2020 - 05/2007)
7.	Su, Ling: 4 articles (11/2022 - 11/2011)
8.	Kim, Shin: 4 articles (04/2021 - 04/2013)
9.	Min, Kyoung-Jin: 4 articles (10/2020 - 03/2012)
10.	Park, Jong-Wook: 4 articles (10/2020 - 08/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/09/2020 - "Taken together, these results suggest that DEX inhibits TRAIL-mediated apoptosis via GSK-3β-mediated DR5 downregulation and c-FLIP(L) upregulation in cancer cells." 07/01/2014 - "ER, PR, HER2, Ki-67, CK5/6 and EGFR were evaluated by immunohistochemistry in order to classify the tumors into five molecular subtypes and the difference of c-FLIP(L) expression in these molecular subtypes was also analyzed. " 12/01/2012 - "Collectively, our results suggest that a regulated ERK1/2 pathway is crucial to control FLIP(L) levels and sensitivity to TRAIL in non-transformed cells, and this mechanism may explain the increased sensitivity of tumor cells to TRAIL, in which the ERK1/2 pathway is frequently deregulated." 01/01/2012 - "Reduced CaM binding by the H204 mutant resulted in increased sensitivity to Fas-mediated apoptosis and inhibited tumor growth in mice compared with wild-type c-FLIP(L). " 12/01/2010 - "These results indicate the existence of a new mechanism of resistance to TRAIL in cancer cells, and unexpected functions of c-FLIP(L)."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 02/01/2001 - "The most striking findings were the overexpression of Fas decoy receptors (DcR3), Fas associated phosphatase-1 (FAP-1), and FLICE-inhibitory protein (c-FLIP) in the resistant cell lines as well as in pancreatic cancer surgical specimens. " 04/01/2012 - "Pancreatic cancer cells sorted for high c-FLIP(L) expression formed peritoneal implants much more readily than cells with low c-FLIP(L) expression, and RNAi inhibition of c-FLIP(L) in colon cancer cells dramatically reduced peritoneal implantation. " 10/01/2013 - "Cellular FLICE inhibitory protein expression status is a valuable prognostic biomarker in pancreatic cancer." 04/01/2012 - "BAY 11-7085 rapidly inhibited c-FLIP(L) expression in colon and pancreatic cancer cell lines during adhesion to mesothelial cells. " 07/01/2005 - "Pancreatic cancer cells are resistant to TRAIL-induced apoptosis via strong expression of the anti-apoptotic protein FLIP-S. "
3.	Colonic Neoplasms (Colon Cancer) 03/01/2006 - "Recent reports have suggested that TRP53 may influence the ubiquitinylation and consequent proteosomal degradation of a negative regulator of FAS, CFLAR (L) (c-FLIP [L]), in human colon cancer cells. " 04/28/2005 - "Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer." 08/23/2001 - "Here we report that p53 suppressed expression of the cellular FLICE-inhibitory protein (FLIP) that potentially blocks apoptotic signaling in human colon cancer cell lines expressing mutated and wild-type p53. " 04/01/2012 - "Pancreatic cancer cells sorted for high c-FLIP(L) expression formed peritoneal implants much more readily than cells with low c-FLIP(L) expression, and RNAi inhibition of c-FLIP(L) in colon cancer cells dramatically reduced peritoneal implantation. " 07/01/2009 - "S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells."
4.	Multiple Sclerosis 10/01/2007 - "Our results suggest that vaccination protocols designed to enhance FLIP(L) expression in T cells may be useful for the treatment of autoimmune diseases like multiple sclerosis, without necessarily compromising immune responses towards infectious agents."
5.	Autoimmune Diseases (Autoimmune Disease) 10/01/2007 - "Our results suggest that vaccination protocols designed to enhance FLIP(L) expression in T cells may be useful for the treatment of autoimmune diseases like multiple sclerosis, without necessarily compromising immune responses towards infectious agents."

Related Drugs and Biologics

1.	Caspases
2.	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)
3.	Enzymes
4.	Death Domain Receptors
5.	Proteins (Proteins, Gene)
6.	Caspase 8 (Caspase-8)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Protein Isoforms (Isoforms)
9.	Small Interfering RNA (siRNA)
10.	Proteasome Endopeptidase Complex (Proteasome)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Aftercare (After-Treatment)