Hand-Arm Vibration Syndrome

An occupational disorder resulting from prolonged exposure to vibration, affecting the fingers, hands, and forearms. It occurs in workers who regularly use vibrating tools such as jackhammers, power chain saws, riveters, etc. Symptoms include episodic finger blanching, NUMBNESS, tingling, and loss of nerve sensitivity.

Also Known As:

Hand Arm Vibration Syndrome; Hand-Arm Vibration Syndromes; Syndrome, Hand-Arm Vibration; Syndromes, Hand-Arm Vibration; Vibration Syndrome, Hand-Arm; Vibration Syndromes, Hand-Arm

Networked: 35 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Pain
2.	Complex Regional Pain Syndromes
3.	Thromboangiitis Obliterans (Buerger's Disease)
4.	Systemic Scleroderma (Systemic Sclerosis)
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease)

Experts

1.	Alvarez, Pedro: 2 articles (01/2019 - 04/2016)
2.	Bogen, Oliver: 2 articles (01/2019 - 04/2016)
3.	Levine, Jon D: 2 articles (01/2019 - 04/2016)
4.	Dong, Ren G: 2 articles (03/2015 - 01/2006)
5.	Arsenault, Marc: 1 article (08/2021)
6.	Chadefaux, Delphine: 1 article (08/2021)
7.	Eger, Tammy: 1 article (08/2021)
8.	Goggins, Katie A: 1 article (08/2021)
9.	Lievers, W Brent: 1 article (08/2021)
10.	Tarabini, Marco: 1 article (08/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hand-Arm Vibration Syndrome:

1.	Norepinephrine (Noradrenaline)FDA LinkGeneric 05/01/1994 - "When exposed to whole body cooling, hand-arm vibration syndrome patients showed a significantly greater increase of plasma norepinephrine than the age-matched healthy controls. " 05/01/1994 - "The excess secretion of norepinephrine in blood reveals that the responsiveness of the sympathetic nervous system to cold exposure is enhanced in hand-arm vibration syndrome patients. "
2.	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 03/01/2008 - "Re: nerve conduction studies (NCS) and current perception thresholds (CPT) in workers assessed for hand-arm vibration syndrome (HAVS)." 09/01/2010 - "The aim of this review of selected reports is to provide an overview of CPT measurement for the assessment of the neurological component of hand-arm vibration syndrome (HAVS). " 10/01/2009 - "To examine the association between the hand-arm vibration syndrome (HAVS) Stockholm sensorineural scale stages and tests of peripheral neurological function including measurement of current perception threshold (CPT) and nerve conduction. "
3.	Biomarkers (Surrogate Marker)IBA 12/01/2023 - "A Study on Vascular Regulators as Early Biomarkers of Hand Arm Vibration Syndrome." 01/01/2023 - "Vinculin Identified as a Potential Biomarker in Hand-Arm Vibration Syndrome Based on iTRAQ and LC-MS/MS-Based Proteomic Analysis."
4.	CatecholaminesIBA 03/01/2004 - "The aim of this study was to evaluate heart rate variation and urinary catecholamines in response to acute psychological stress in hand-arm vibration syndrome (HAVS) patients and healthy controls. " 03/01/2004 - "Heart rate variation and urinary catecholamine excretion in response to acute psychological stress in hand-arm vibration syndrome patients." 01/01/1995 - "We investigated urinary catecholamines' response to acute psychological stress test in hand-arm vibration syndrome patients. "
5.	Iloprost (Ventavis)FDA Link 06/01/2004 - "We suggest that the use of iloprost in the treatment of the most advanced stages of vascular hand-arm vibration syndrome warrants further study" 06/01/2004 - "To evaluate the efficacy and tolerance of therapy with iloprost in hand-arm vibration syndrome. " 06/01/2004 - "Effectiveness of therapy with iloprost in hand-arm vibration syndrome."
6.	MetalsIBA 01/01/2001 - "The objective of this study was to determine the prevalence of hand-arm vibration syndrome (HAVS) in 617 workers at a base metal mine in northern Ontario. " 01/01/2001 - "Assessment of hand-arm vibration syndrome in a northern Ontario base metal mine."
7.	Dihydrotachysterol (AT 10)IBA 05/01/2005 - "Effects of waterproof covering on hand immersion tests using water at 10 degrees C, 12 degrees C and 15 degrees C for diagnosis of hand-arm vibration syndrome." 04/01/1998 - "For diagnosing the hand-arm vibration syndrome, peripheral circulation and sensory tests immersing one hand in cold water at 10 degrees C for 10 min have been performed widely in Japan. "
8.	Kv1.4 Potassium ChannelIBA 01/01/2019 - "Interleukin 6 decreases nociceptor expression of the potassium channel KV1.4 in a rat model of hand-arm vibration syndrome."
9.	Therapeutic UsesIBA 01/01/1995 - "We applied Stockholm criterion to patients with hand-arm vibration syndrome (HAVS) for assessing the therapeutic effects in comparison with the criterion of the Ministry of Labour in Japan (MLJ). "
10.	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 04/01/2016 - "We hypothesized that changes in the expression of voltage-gated potassium channel (Kv) 4.3 contribute to the mechanical hyperalgesia induced by vibration injury, in a rodent model for hand-arm vibration syndrome in humans. "

Therapies and Procedures

1.	Lasers (Laser) 04/01/2007 - "The objective of this study was to evaluate the usefulness of laser Doppler imaging (LDPI) of the skin blood flow for assessing peripheral vascular impairment in the hand-arm vibration syndrome (HAVS). " 08/01/2021 - "Abbreviations: COP: centre of pressure; DOF: degrees-of-freedom; FAS: foot-ankle system; FTV: foot-transmitted vibration; HAVS: hand-arm vibration syndrome; LDV: laser Doppler vibrometer; LP: lumped-parameter; VWT: vibration-induced white-toes; WBV: whole-body vibration." 04/01/2007 - "Laser Doppler imaging of skin blood flow for assessing peripheral vascular impairment in hand-arm vibration syndrome."
2.	Rewarming 09/01/2011 - "Rewarming curves and derived parameters in the diagnosis of hand-arm vibration syndrome." 08/01/2003 - "A critique of a UK standardized test of finger rewarming after cold provocation in the diagnosis and staging of hand-arm vibration syndrome."
3.	Lipectomy (Liposuction) 01/01/2021 - "As power-assisted liposuction (PAL) gains in popularity, plastic surgeons operating these devices experience occupational exposure to hand-transmitted vibration, which can result in hand-arm vibration syndrome, a debilitating neurovasculopathy. "
4.	Therapeutics 06/01/2004 - "To evaluate the efficacy and tolerance of therapy with iloprost in hand-arm vibration syndrome. " 06/01/2004 - "Effectiveness of therapy with iloprost in hand-arm vibration syndrome."
5.	Replantation 05/01/2015 - "This is a review of the literature, demonstrating the collected knowledge of decreased hand vascularity due to tobacco use and assessing the evidence connecting smoking and supposed resultant maladies, including Raynaud's phenomenon, hand-arm vibration syndrome, Buerger's disease, Dupuytren's contracture, carpal tunnel syndrome, effects on skin and fingernails, decreased skin and bone healing, complications of digit replantation and complex regional pain syndrome. "