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IDL Lipoproteins (Lipoprotein, IDL)

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A mixture of very-low-density lipoproteins (VLDL), particularly the triglyceride-poor VLDL, with slow diffuse electrophoretic mobilities in the beta and alpha2 regions which are similar to that of beta-lipoproteins (LDL) or alpha-lipoproteins (HDL). They can be intermediate (remnant) lipoproteins in the de-lipidation process, or remnants of mutant CHYLOMICRONS and VERY-LOW-DENSITY LIPOPROTEINS which cannot be metabolized completely as seen in FAMILIAL DYSBETALIPOPROTEINEMIA.

Also Known As:

Lipoprotein, IDL; Lipoproteins, IDL; Broad-beta Lipoproteins; Floating beta-Lipoproteins; Intermediate Density Lipoproteins; Intermediate-Density Lipoproteins; Lipoproteins, Intermediate Density; alpha2-VLDL; alpha2-VLDL Lipoprotein; beta-VLDL; beta-VLDL Lipoproteins; IDL Lipoprotein; Lipoprotein, alpha2-VLDL; Lipoproteins, Intermediate-Density; Lipoproteins, alpha2-Very-Low-Density; alpha2 VLDL; alpha2 VLDL Lipoprotein; alpha2 Very Low Density Lipoproteins; alpha2-Very-Low-Density Lipoproteins; beta-Very-Low-Density Lipoproteins

Networked: 223 relevant articles (6 outcomes, 24 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Brunzell, John D: 2 articles (05/2014 - 10/2003)
2.	Hirowatari, Yuji: 2 articles (10/2013 - 09/2005)
3.	Yoshida, Hiroshi: 2 articles (10/2013 - 09/2005)
4.	Tada, Norio: 2 articles (10/2013 - 09/2005)
5.	Kurosawa, Hideo: 2 articles (10/2013 - 09/2005)
6.	Samuelsson, Ola: 2 articles (08/2011 - 01/2002)
7.	Alaupovic, Petar: 2 articles (08/2011 - 01/2002)
8.	Attman, Per-Ola: 2 articles (08/2011 - 01/2002)
9.	Tabata, Tsutomu: 2 articles (12/2009 - 01/2002)
10.	Nishizawa, Yoshiki: 2 articles (12/2009 - 01/2002)

Related Diseases

1.	Hypercholesterolemia 08/01/1985 - "Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits." 10/16/1992 - "This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. " 10/01/1998 - "Our results suggest that hypercholesterolemia can affect monocyte metabolism enhancing foam cell formation by increasing the influx of peroxynitrite-modified beta-VLDL." 01/28/1991 - "The FCR of the same lipoproteins injected into hypercholesterolemic pigeons was reduced by 17% for nLDL, 50% for hLDL and 57% for beta-VLDL, indicating that the effect of hypercholesterolemia on clearance in vivo was different for the three lipoproteins. " 10/01/1989 - "Dietary restriction, which enhances the hypercholesterolemia induced by cholesterol feeding, had no additional effect on the down-regulation of beta-VLDL specific binding. "
2.	Cardiovascular Diseases (Cardiovascular Disease) 11/01/1999 - "Familial type III hyperlipoproteinemia (HLP) is characterized by the presence of beta-migrating VLDL (beta-VLDL) and increased risk of cardiovascular disease. " 01/01/2015 - "We conducted a genome-wide association analysis of 7 subfractions of low density lipoproteins (LDLs) and 3 subfractions of intermediate density lipoproteins (IDLs) measured by gradient gel electrophoresis, and their response to statin treatment, in 1868 individuals of European ancestry from the Pharmacogenomics and Risk of Cardiovascular Disease study. " 06/01/1988 - "High levels of low-density lipoproteins and intermediate-density lipoproteins, as well as their apoproteins, are strong risk factors for cardiovascular disease. " 10/01/1994 - "Several mechanisms of estrogen mediated protection from cardiovascular disease have been identified including increased HDL, lower LDL, lower VLDL-cholesterol/triglyceride ratio, increased clearance of intermediate density lipoprotein (IDL) and LDL via an upregulated LDL receptor, diminished penetration and degradation of LDL in the arterial wall, an inhibition of LDL oxidation by various estrogens and a reversal of inappropriate acetylcholine (EDRF)-mediated vasoconstriction in arteriosclerotic vessels. "
3.	Coronary Stenosis (Coronary Artery Stenosis) 05/01/2014 - "Improvement in coronary stenosis was significantly associated with the decrease of cholesterol in the dense low-density lipoprotein (LDL) particles and across most of the intermediate density lipoprotein (IDL) and very low density lipoprotein particle density range, but, not with any of the HDL fraction or of the more buoyant LDL fractions. "
4.	Acute-Phase Reaction 10/01/1984 - "Furthermore the apparent rates of clearance of 125I-labelled beta-VLDL, VLDL and LDL did not differ between normal rabbits and rabbits undergoing an acute phase response. "
5.	Atherosclerosis 12/01/1998 - "Thus evidence from clinical studies linking hypertriglyceridaemia with potentially important atherogenic factors such as intermediate density lipoproteins, small dense LDL and increased cholesteryl ester exchange may provide a greater understanding of atherogenesis and potential sites of therapeutic intervention than epidemiology. " 06/01/1999 - "It is now widely appreciated that remnants of triglyceride-rich lipoproteins, IDL and specific LDL subfractions may have a role in atherogenesis disproportionate to the plasma concentrations of these species. " 03/01/1992 - "The abnormal accumulation of beta-VLDL may be one of the possible explanations for the rapid, premature atherosclerosis in the two siblings with FCHL in this kindred. " 01/01/1989 - "It may be that beta-VLDL also plays a role in determining the level of vascular tonus in atherosclerosis." 11/01/1987 - "This VLDL-subfraction (VLDL-2) has a similar chemical composition to beta-VLDL which has been suggested to be of importance in the development of atherosclerosis. "

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Cholesterol
3.	LDL Receptors (LDL Receptor)
4.	Cholesterol Esters (Cholesteryl Esters)
5.	VLDL Cholesterol
6.	low density lipoprotein inhibitor
7.	Estrogens (Estrogen)
8.	Acetylcholine (Acetylcholine Chloride)
9.	Apolipoproteins B (ApoB)
10.	LDL Lipoproteins (beta Lipoproteins)

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Transplants (Transplant)
3.	Renal Dialysis (Hemodialysis)