Lymphotoxin-beta

A membrane-bound tumor necrosis family member found primarily on LYMPHOCYTES. It can form a heterotrimer (LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER) with the soluble ligand LYMPHOTOXIN-ALPHA and anchor it to the cell surface. The membrane-bound complex is specific for the LYMPHOTOXIN BETA receptor.

Also Known As:

Networked: 50 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Briscoe, H: 2 articles (08/2005 - 01/2001)
2.	Britton, W J: 2 articles (08/2005 - 01/2001)
3.	Roach, D R: 2 articles (08/2005 - 01/2001)
4.	Qin, Chuanjie: 1 article (03/2022)
5.	Shi, Xiaotao: 1 article (03/2022)
6.	Tan, Junjun: 1 article (03/2022)
7.	Xie, Jiang: 1 article (03/2022)
8.	Hu, Peng: 1 article (01/2021)
9.	Huang, Runzhi: 1 article (01/2021)
10.	Huang, Zongqiang: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 03/01/2004 - "In addition, intestinal inflammation is suppressed by inhibition of lymphotoxin beta signalling, an observation which has initiated clinical studies using this treatment principal. " 11/03/2023 - "Long Non-Coding RNA AL928768.3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway." 11/03/2023 - "Our previous study using RNA sequencing and reverse transcription quantitative polymerase chain reaction (RT-qPCR) validation identified a long non-coding RNA (lnc), lnc-AL928768.3, correlating with risk and disease activity of rheumatoid arthritis (RA), then the present study was conducted to further investigate the interaction of lnc-AL928768.3 with lymphotoxin beta (LTB) and their impact on proliferation, migration, invasion, and inflammation in RA-fibroblast-like synoviocytes (RA-FLS). " 06/01/2005 - "Lymphotoxin-beta (LT-beta) plays an important role in inflammation and its promoter contains a functional nuclear factor-kappaB (NF-kappaB) element, rendering it a likely target of pro-inflammatory cytokines. " 01/01/2023 - "Post hoc comparisons of data obtained from samples of patients in C1, C2, and C3 revealed significant differences in the levels of oxidative stress and inflammation-related markers, including 3-nitrotyrosine, tumor necrosis factor, C-reactive protein, interleukin (IL) 1β, IL-6, platelet-derived growth factor (PDGF)-AA, and PDGF-BB. "
2.	Necrosis 09/01/1989 - "Human recombinant tumour necrosis factor beta (rhuTNF beta)/lymphotoxin was tested for human neutrophil granulocyte (PMN), monocytes (MO), and T-cell chemotactic activity by means of a modified Boyden chamber system. " 09/01/1989 - "Recombinant human tumour necrosis factor beta (lymphotoxin) lacks chemotactic activity for human peripheral blood neutrophils, monocytes, and T cells." 03/01/1988 - "The data presented here demonstrate that recombinant human tumour necrosis factor beta (rHuTNF beta; lymphotoxin) is a neutrophil modulator. " 03/01/1988 - "Tumour necrosis factor beta (lymphotoxin) inhibits locomotion and stimulates the respiratory burst and degranulation of neutrophils." 09/01/2003 - "Animal studies suggest that members of the tumour necrosis factor family, including lymphotoxin beta (LT-beta), regulate oval cell proliferation in liver disease, but its role in human liver disease is unclear. "
3.	Rheumatoid Arthritis 07/01/2004 - "Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis." 08/01/2008 - "High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations." 11/03/2023 - "Long Non-Coding RNA AL928768.3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway." 11/03/2023 - "Our previous study using RNA sequencing and reverse transcription quantitative polymerase chain reaction (RT-qPCR) validation identified a long non-coding RNA (lnc), lnc-AL928768.3, correlating with risk and disease activity of rheumatoid arthritis (RA), then the present study was conducted to further investigate the interaction of lnc-AL928768.3 with lymphotoxin beta (LTB) and their impact on proliferation, migration, invasion, and inflammation in RA-fibroblast-like synoviocytes (RA-FLS). "
4.	Liver Diseases (Liver Disease) 09/01/2003 - "Animal studies suggest that members of the tumour necrosis factor family, including lymphotoxin beta (LT-beta), regulate oval cell proliferation in liver disease, but its role in human liver disease is unclear. "
5.	Infections 08/01/2004 - "MAdCAM-1 expressing sacral lymph node in the lymphotoxin beta-deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection." 08/01/2009 - "Altered proinflammatory cytokine production and enhanced resistance to Trypanosoma congolense infection in lymphotoxin beta-deficient mice." 08/01/2005 - "Although the essential role of tumor necrosis factor (TNF) in resistance to Listeria monocytogenes infection is well established, the roles of the related cytokines lymphotoxin alpha (LTalpha) and lymphotoxin beta (LTbeta) are unknown. " 11/21/2001 - "The combination of thermal injury plus PAO1 infection enhanced the expression of several pro-inflammatory and haematopoietic cytokines [stem cell factor (SCF), leukocyte inhibitory factor (LIF), IL-6 and TNF-alpha]; induced the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF by 5 h and the expression of additional cytokines, including TGF-beta, TNF-beta, lymphotoxin beta (LT-beta), interferon gamma (IFN-gamma), and IFN-beta by 40 h post-burn/infection. "

Related Drugs and Biologics

1.	Long Noncoding RNA
2.	RNA (Ribonucleic Acid)
3.	Cytokines
4.	Lymphotoxin-alpha (Lymphotoxin)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Proteins (Proteins, Gene)
7.	Interleukin-6 (Interleukin 6)
8.	Interleukins
9.	Chemokines
10.	Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1.	Moxibustion
2.	Injections
3.	Drug Therapy (Chemotherapy)