Chylomicron Remnants

Metabolic products of chylomicron particles in which TRIGLYCERIDES have been selectively removed by the LIPOPROTEIN LIPASE. These remnants carry dietary lipids in the blood and are cholesterol-rich. Their interactions with MACROPHAGES; ENDOTHELIAL CELLS; and SMOOTH MUSCLE CELLS in the artery wall can lead to ATHEROSCLEROSIS.

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Networked: 201 relevant articles (25 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamashita, Shizuya: 6 articles (02/2017 - 06/2007)
2.	Botham, K M: 6 articles (11/2011 - 07/2000)
3.	Redgrave, T G: 6 articles (12/2005 - 02/2001)
4.	Masuda, Daisaku: 5 articles (02/2017 - 05/2009)
5.	Vaziri, Nosratola D: 5 articles (04/2014 - 11/2009)
6.	Botham, Kathleen M: 5 articles (10/2009 - 11/2002)
7.	Fujioka, Yoshio: 5 articles (06/2007 - 12/2003)
8.	Watts, G F: 5 articles (12/2005 - 02/2001)
9.	James, Anthony P: 4 articles (09/2016 - 05/2002)
10.	Mamo, John C L: 4 articles (09/2016 - 05/2002)

Related Diseases

1.	Atherosclerosis 04/01/2000 - "Rabbits which are susceptible to diabetes induced atherogenesis had significantly greater intimal retention of chylomicron remnants compared to rats. " 05/04/2002 - "Ageing is associated with impaired clearance of chylomicron remnants, postprandial hypertriglyceridaemia, and hence, atherosclerosis, which we propose is linked directly to loss of permeability of the liver sieve because of defenestration associated with pseudocapillarisation. " 11/01/1992 - "Octogenarian subjects have low postprandial levels of chylomicron remnants: a possible explanation for protection against atherosclerosis." 10/01/2005 - "This study proposes a mechanism of atherosclerosis induced by chylomicron remnants." 09/01/2003 - "This study provides further evidence to support a role of chylomicron remnants in the development of atherosclerosis."
2.	Hypertriglyceridemia 06/01/1985 - "This study was conducted to determine whether chylomicron remnants accumulate in the plasma of patients with "endogenous" hypertriglyceridemia. " 02/05/1991 - "Impaired clearance of chylomicron remnants possibly contributes to the hypertriglyceridemia of WHHL rabbits and to accelerated atherogenesis when the function of LDL receptors is defective." 06/01/1985 - "Postchallenge plasma lipoprotein retinoids: chylomicron remnants in endogenous hypertriglyceridemia." 05/16/1983 - "Since apolipoprotein B-48 appears to be a marker for remnants of intestinal particles, its slower removal than that of apolipoprotein B-100 in severe hypertriglyceridemia suggests that one metabolic defect associated with the hyperchylomicronemia is defective removal of chylomicron remnants." 04/01/2013 - "More often, severe hypertriglyceridemia describes various clinical conditions characterized by high plasma levels of triglycerides (>1000 mg/dL), chylomicron remnants, or intermediate density lipoprotein like particles, and/or chylomicrons. "
3.	Hypothyroidism 07/01/1999 - "We conclude that T4 enhances the clearance of chylomicron remnants in normolipidemic patients with hypothyroidism." 02/01/1981 - "Effects of hypothyroidism and cholesterol feeding on the clearance of chylomicron remnants in vivo and by rat hepatocyte monolayers." 07/01/1999 - "Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism." 02/01/1981 - "Thus, the study suggests that chylomicron remnant uptake by the liver is not inhibited by hypothyroidism per se but by the cholesterol accumulation in hepatocytes that is the consequence of cholesterol and bile acid feeding of the rats. " 01/01/2013 - " Such altered serum levels of ApoB-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism."
4.	Hyperlipidemias (Hyperlipidemia) 04/01/1994 - "Improved methods for quantification of organ-specific contributions to postprandial hyperlipidemia indicate substantial increases in the concentration and altered properties of hepatogenous VLDL, in addition to accumulation of chylomicron remnants. " 04/01/2016 - "Postprandial hyperlipidemia is a condition in which TG-rich chylomicron remnants are increased during the postprandial period and hypertriglycedemia is protracted. " 06/01/2008 - "This provides a mechanism for impaired chylomicron remnant clearance and postprandial hyperlipidemia associated with old age. " 06/01/2000 - "In this article recent information on the control of postprandial lipemia and the biological effects of chylomicron remnants and lipolysis products will be reviewed. " 04/01/1998 - "An increase in age is associated with increased VLDL and postprandial lipemia and decreased chylomicron remnant clearance. "
5.	Dyslipidemias (Dyslipidemia) 01/01/2005 - "Delayed clearance of chylomicron remnants from the blood occurs in a number of dyslipidemias associated with premature atherosclerosis development, and the potentially atherogenic effects of the particles would clearly be enhanced in these circumstances. " 06/01/2010 - "Intestinally derived chylomicron remnants (CM-r) are also thought to contribute to atherogenic dyslipidemia during insulin resistance. " 08/26/2003 - "The findings suggest that the apoE2-induced dyslipidemia is not merely the result of substitution of R158 for C but results from increased secretion of a triglyceride-enriched VLDL that cannot undergo lipolysis, inhibition of LpL activity, and impaired clearance of chylomicron remnants. " 02/01/2022 - "Euglycemic lean adolescents with IR display TRL dyslipoproteinemia with increased inhibition of LPL as highlighted by higher concentrations of ANGPTL-3, ApoC-III and fasting chylomicron remnants (ApoB-48)." 01/01/2009 - "In patients with postprandial dyslipidemia, metabolic pathways for exogenous lipoproteins are generally disturbed, resulting in accumulation of chylomicron remnants. "

Related Drugs and Biologics

1.	Chylomicrons
2.	LDL Receptors (LDL Receptor)
3.	VLDL Lipoproteins
4.	Cholesterol
5.	Lipoproteins (Lipoprotein)
6.	Lipids
7.	Triglycerides (Triacylglycerol)
8.	oxidized low density lipoprotein
9.	HDL Lipoproteins
10.	IDL Lipoproteins (Lipoprotein, IDL)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration