Apolipoprotein B-48

A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.

Also Known As:

Networked: 142 relevant articles (8 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamashita, Shizuya: 15 articles (01/2014 - 06/2003)
2.	Masuda, Daisaku: 10 articles (01/2014 - 11/2009)
3.	Watts, Gerald F: 9 articles (03/2015 - 02/2003)
4.	Chan, Dick C: 7 articles (03/2015 - 02/2003)
5.	Barrett, P Hugh R: 7 articles (03/2015 - 02/2003)
6.	Nishida, Makoto: 7 articles (01/2014 - 01/2011)
7.	Ohama, Tohru: 7 articles (09/2012 - 11/2009)
8.	Adeli, Khosrow: 6 articles (10/2015 - 08/2002)
9.	Hanada, Hiroyuki: 6 articles (01/2014 - 11/2009)
10.	Ishigami, Masato: 6 articles (09/2012 - 01/2011)

Related Diseases

1.	Atherosclerosis 07/01/2012 - "In patients not using statins, the surrogate atherosclerosis marker IMT correlates best with apoB48, suggesting that fasting apoB48 may help to detect subjects at risk." 07/01/2012 - "Exploring the value of apoB48 as a marker for atherosclerosis in clinical practice." 09/01/2011 - "Serum apoB-48 level might be a good marker for the detection of early atherosclerosis in middle-aged subjects with normal-range levels of blood pressure and TG." 06/20/2000 - "A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis." 01/18/2012 - "The serum concentration of apoB-48 at fasting has been reported to be a marker of postprandial hyperlipidemia, a presumed risk factor for atherosclerosis. "
2.	Coronary Artery Disease (Coronary Atherosclerosis) 06/05/2013 - "Fasting serum concentration of apolipoprotein B48 represents residual risks in patients with new-onset and chronic coronary artery disease." 09/01/2012 - "Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence." 08/02/1996 - "Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study." 01/01/2012 - "Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state." 09/01/2010 - "Therefore, increased serum apoB-48 concentrations may contribute to the increased risk of atherosclerosis and coronary artery disease in the CKD patients."
3.	Hypertriglyceridemia 11/01/2005 - "Fasting apoprotein B-48 level and coronary artery disease in a population without frank fasting hypertriglyceridemia." 01/01/2014 - "The fractional catabolic rate of apoB-48 was significantly lower in the obese men compared with the lean men (-33%, P<.05) CONCLUSION: We demonstrate that postprandial hypertriglyceridemia in central obesity relates to an overproduction and impaired catabolism of apoB-48-containing lipoproteins. " 01/21/1994 - "These observations indicate that the primary defect leading to hypertriglyceridemia in apoC-III overexpressers is an impaired clearance of apoB48 remnants due to apoE insufficiency. " 05/16/1983 - "Since apolipoprotein B-48 appears to be a marker for remnants of intestinal particles, its slower removal than that of apolipoprotein B-100 in severe hypertriglyceridemia suggests that one metabolic defect associated with the hyperchylomicronemia is defective removal of chylomicron remnants." 02/01/2008 - "Therefore, the objective of this 2-group parallel study was to examine the differential effects of a 6-week treatment with atorvastatin or fenofibrate on in vivo kinetics of apo B-48 and B-100 in men with type 2 diabetes mellitus with marked hypertriglyceridemia. "
4.	Insulin Resistance 09/01/2008 - "In particular, increase in apolipoprotein B48 synthesis has been demonstrated in animal models of diabetes and insulin resistance. " 11/01/2012 - "However, it remains unknown whether fasting serum levels of apoB48 are independently correlated with insulin resistance and vascular inflammation in humans. " 06/01/2007 - "Since little is known about postprandial dyslipidaemia in overweight children, we sought to compare fasting levels of apoB48 with the HOMA-IR (homoeostasis model assessment of insulin resistance) score, classic lipid profile and VAT (visceral adipose tissue). " 06/01/2006 - "There was no significant difference in clearance of apoB-48 between the 2 groups, nor was there a significant correlation between apoB-48 fractional clearance rate and fasting insulin or homeostasis model assessment-insulin resistance. " 01/01/2014 - "These data indicate that short-term supplementation with MCT has a neutral effect on TRL apo B-48 and VLDL apo B-100 kinetics and on the intestinal expression of genes involved in lipid and fatty acid metabolism in men with insulin resistance. "
5.	Hypobetalipoproteinemias (Hypobetalipoproteinemia) 01/01/1998 - "[Hypo beta-lipoproteinemia with selective deletion of apo B-48]." 11/01/1993 - "Postprandial lipemia in subjects with hypobetalipoproteinemia and a single intestinal allele for apoB-48." 03/01/1998 - "In summary this novel mutation is associated with hypobetalipoproteinemia with a normal fat absorption as expected for a protein with a length similar to that of apo B-48." 03/01/1998 - "Hypobetalipoproteinemia associated with apo B-48.4, a truncated protein only 14 amino acids longer than apo B-48." 11/01/1993 - "Our aims were to assess whether intestinal fat absorption differed from normal in subjects with apoB-truncation-associated hypobetalipoproteinemia and whether fat absorption in heterozygotes with apoB < 48 differed from heterozygotes with apoB > 48. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Lipoproteins (Lipoprotein)
3.	Apolipoprotein B-100 (Apo B 100)
4.	Apolipoproteins B (ApoB)
5.	Apolipoproteins E (ApoE)
6.	Lipoprotein Lipase (Diacylglycerol Lipase)
7.	Chylomicrons
8.	Triglycerides (Triacylglycerol)
9.	Apolipoprotein C-III
10.	Squalene

Related Therapies and Procedures

1.	Endarterectomy (Thromboendarterectomy)