OX40 Receptors

A tumor necrosis family receptor with specificity for OX40 LIGAND. It is found on the surface of activated T-LYMPHOCYTES where it plays a role in enhancing cytokine production and proliferation of CD4-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

Receptors, OX40; CD134 Antigen; OX40 Receptor; Antigen, CD134; Receptor, OX40; Antigens, CD134; CD134 Antigens; OX40 Protein; Receptors, Tumor Necrosis Factor, Member 4; Tumor Necrosis Factor Receptor Superfamily, Member 4

Networked: 31 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        OX40 Receptors: 31
        human TNFRSF4 protein
        mouse Tnfrsf4 protein
        rat Tnfrsf4 protein
  - Immune Checkpoint Proteins: 1217
    - OX40 Receptors: 31

Experts

1.	Weinberg, Andrew D: 2 articles (01/2019 - 05/2009)
2.	Eskandari, Nahid: 2 articles (10/2018 - 07/2018)
3.	Tanaka, Yuetsu: 2 articles (01/2018 - 04/2011)
4.	Lane, Peter J L: 2 articles (06/2016 - 08/2011)
5.	Baruah, Paramita: 2 articles (07/2012 - 03/2012)
6.	Dumitriu, Ingrid E: 2 articles (07/2012 - 03/2012)
7.	Kaski, Juan Carlos: 2 articles (07/2012 - 03/2012)
8.	Gamaleldin, Marwa Ahmed: 1 article (10/2021)
9.	Imbaby, Salma Alaa Eldin: 1 article (10/2021)
10.	Abedalthagafi, Malak: 1 article (06/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Evidence from healthy donors and cancer patients reveals a common regulation for the translation of CTLA4, LAG3, TIM3, TIGIT, and BTLA but not of the stimulatory co-receptors OX40, GITR, and 4-1BB mRNAs. " 01/01/2017 - "Modulating PD-L1 and OX40 receptor signaling combined with intratumoral ADU S-100 administration enhanced HER-2-specific CD8+ T-cell activity, clearing tumors in 40% of neu/N mice. " 01/01/2017 - "Immune cell infiltrates of untreated tumor-bearing neu/N mice expressed high numbers of PD1 and OX40 receptors on their CD8+ T cells, and PD-L1 was highly expressed on both myeloid and tumor cells. " 04/21/2020 - "In a syngeneic PC murine tumor model, HT was delivered before tumor-targeted RT, by a small animal radiation research platform (SARRP) followed by intraperitoneal injections of cytotoxic T-cell agonist antibody against OX40 (also known as CD134 or Tumor necrosis factor receptor superfamily member 4; TNFRSF4) that can promote T-effector cell activation and inhibit T-regulatory (T-reg) function. " 01/01/2016 - "OX40 receptor-expressing regulatory T cells (Tregs) populate tumors and suppress a variety of immune cells, posing a major obstacle for cancer immunotherapy. "
2.	Necrosis 08/01/2011 - "Our previous studies have implicated signaling through the tumor necrosis family receptors OX40 and CD30 as critical for maintaining CD4 memory responses. " 01/01/2021 - "The tumour necrosis factor receptor OX40 is activated by its cognate ligand OX40L (TNFSF4) and functions as a T-cell costimulatory molecule. " 06/01/2016 - "The tumour necrosis factor receptor OX40 (CD134) is activated by its cognate ligand OX40L (CD134L, CD252) and functions as a T cell co-stimulatory molecule. "
3.	Allergic Rhinitis 10/01/2018 - "This study aimed to investigate the in vitro anti-allergic effect of GA through the OX40 receptor in patients with allergic rhinitis. " 10/01/2018 - "The In Vitro Impact of Glycyrrhizic Acid on CD4+ T Lymphocytes through OX40 Receptor in the Patients with Allergic Rhinitis."
4.	Inflammation (Inflammations) 10/01/2012 - "Here we found that the costimulatory receptor OX40 was a powerful inducer of T(H)9 cells in vitro and T(H)9 cell-dependent airway inflammation in vivo. " 02/05/2001 - "Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40." 07/01/2018 - "Increased expression of OX40 protein (CD134) is a known factor for increased inflammation and initiation of NF-kappa-B signaling pathway in different diseases. "
5.	Malaria 10/01/2016 - "Surface expression of inhibitory (CTLA-4) and stimulatory (OX40) receptors by CD4+ regulatory T cell subsets circulating in human malaria." 05/13/2015 - "Here we show that malaria patients and Plasmodium-infected rodents exhibit atypical expression of the co-stimulatory receptor OX40 on CD4 T cells and that therapeutic enhancement of OX40 signaling enhances helper CD4 T cell activity, humoral immunity, and parasite clearance in rodents. "

Related Drugs and Biologics

1.	Anti-Allergic Agents (Antiallergic Agents)
2.	Ligands
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Messenger RNA (mRNA)
5.	Immunologic Factors (Immunomodulators)
6.	Antigens
7.	B7-H1 Antigen
8.	CCR4 Receptors
9.	OX40 Ligand
10.	Forkhead Transcription Factors (Forkhead Box Proteins)

Related Therapies and Procedures

1.	Immunotherapy
2.	Intraperitoneal Injections