HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)

Subscribe to New Research on Receptor Activator of Nuclear Factor-kappa B

A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It also expressed on DENDRITIC CELLS where is plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

TRANCE-R; NF-KappaB Receptor Activator; RANK Protein; Receptor Activator of NF-kappa B; Receptor Activator of NF-kappaB; Receptor Activator of Nuclear Factor-kappaB; TNFRSF11A Protein; TRANCE Receptor; Activator, NF-KappaB Receptor; NF Kappa B Receptor Activator; NF KappaB Receptor Activator; Receptor Activator of NF kappa B; Receptor Activator of NF kappaB; Receptor Activator of Nuclear Factor kappa B; Receptor Activator of Nuclear Factor kappaB; Receptor Activator, NF-KappaB; TRANCE R; NF-Kappa B Receptor Activator; Receptors, Tumor Necrosis Factor, Member 11a; Tumor Necrosis Factor Receptor Superfamily, Member 11a

Networked: 301 relevant articles (3 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Immunologic Receptors: 8
        Cytokine Receptors: 788
        Tumor Necrosis Factor Receptors: 2575
        Receptor Activator of Nuclear Factor-kappa B: 301
        human TNFRSF11A protein
        mouse Tnfrsf11a protein

Experts

1.	Aggarwal, Bharat B: 5 articles (11/2011 - 01/2006)
2.	Dougall, William C: 5 articles (01/2008 - 02/2002)
3.	Roux, Sophie: 4 articles (08/2010 - 02/2002)
4.	Takayanagi, Hiroshi: 4 articles (03/2009 - 01/2005)
5.	Hofbauer, Lorenz C: 4 articles (01/2008 - 08/2002)
6.	Heymann, D: 3 articles (02/2015 - 02/2007)
7.	Schett, Georg: 3 articles (06/2013 - 11/2006)
8.	Yoneda, Toshiyuki: 3 articles (12/2012 - 08/2004)
9.	Nanke, Yuki: 3 articles (12/2009 - 12/2007)
10.	Kotake, Shigeru: 3 articles (12/2009 - 12/2007)

Related Diseases

1.	Bone Resorption 01/06/2014 - "Osteoclasts, responsible for bone resorption, express Receptor Activator of Nuclear factor Kappa B (RANK) receptors. " 11/01/2011 - "Recombinant murine RANK protein effectively inhibits the activity of osteoclasts and the resulting bone resorption." 11/01/2011 - "Murine RANK protein's inhibition of bone resorption." 05/15/2009 - "Excessive receptor activator of NF-kappaB ligand (RANKL) signaling causes enhanced osteoclast formation and bone resorption. " 08/01/2008 - "Bone resorption is dependent on receptor activator of NF-kappa B ligand (RANKL), which binds to RANK receptor on preosteoclasts to initiate osteoclastogenesis and maintains osteoclast function and survival. "
2.	Osteolysis 02/01/2002 - "In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis." 08/01/2006 - "Signaling of RANK (receptor activator of nuclear factor kappa B) through its ligand RANKL appears critical in osteolysis associated with aseptic loosening (AL). " 02/01/2005 - "TNF-induced receptor activator NF-kappaB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. " 11/15/2003 - "More importantly, these I-kappaB mutant forms significantly inhibit in vivo production of TNF and receptor activator of NF-kappaB ligand, and block joint swelling, osteoclast recruitment, and osteolysis. " 01/01/2009 - "Enhanced expression and shedding of receptor activator of NF-kappaB ligand during tumor-bone interaction potentiates mammary tumor-induced osteolysis."
3.	Hypercalcemia (Milk Alkali Syndrome) 01/15/2002 - "This study analyzed the expression of various genes that are thought to regulate serum Ca(++) levels in ATL and showed that the overexpression of the receptor activator of nuclear factor kappaB (RANK) ligand gene correlated with hypercalcemia. " 03/15/2001 - "Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy." 07/01/2007 - "Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection."
4.	Osteosarcoma (Osteogenic Sarcoma) 10/01/2008 - "Therapeutic efficacy of soluble receptor activator of nuclear factor-kappa B-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma." 04/01/2007 - "Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B." 03/01/2001 - "Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma." 09/10/2004 - "We have studied the effect of ATRA on osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) expression in human MG-63 osteosarcoma cells and primary osteoblast-like cultures. "
5.	Neoplasms (Cancer) 12/01/2012 - "Recent studies have revealed that osteoblasts mediate this crosstalk by expressing the receptor activator of NF-kappaB ligand (RANKL) in response to cancer-produced osteotropic factors. " 01/01/2008 - "Previous studies in rodent models of breast and prostate cancer have established that receptor activator of NF-kappaB ligand (RANKL) inhibition decreases bone lesion development and tumor growth in bone. " 10/01/2014 - "Receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL) has emerged as a major mediator of bone resorption, commonly associated with cancer and chronic inflammatory diseases. " 01/01/2009 - "Enhanced expression and shedding of receptor activator of NF-kappaB ligand during tumor-bone interaction potentiates mammary tumor-induced osteolysis." 10/01/2008 - "The anti-bone resorption molecule receptor activator of NF-kappaB (RANK) is very promising, as it may block the vicious cycle between bone resorption and tumor proliferation that takes place during tumor development in bone site. "

Related Drugs and Biologics

1.	Titanium
2.	Immunoglobulin G (IgG)
3.	Osteoprotegerin
4.	RANK Ligand
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Macrophage Colony-Stimulating Factor
7.	Cytokines
8.	Interleukins
9.	NF-kappa B (NF-kB)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Tooth Movement
2.	Ovariectomy (Oophorectomy)
3.	Castration