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RANK Ligand

A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Also Known As:
CD254 Antigen; OPGL Protein; Osteoclast Differentiation Factor; Osteoprotegerin Ligand; RANKL Protein; Receptor Activator of Nuclear Factor-kappa B Ligand; Receptor Activator of Nuclear Factor-kappaB Ligand; TNF Superfamily, Member 11; TRANCE Protein; Tumor Necrosis Factor-Related Activation-Induced Cytokine; Antigen, CD254; Differentiation Factor, Osteoclast; Receptor Activator of Nuclear Factor kappa B Ligand; Receptor Activator of Nuclear Factor kappaB Ligand; Tumor Necrosis Factor Related Activation Induced Cytokine; Tumor Necrosis Factor Ligand Superfamily Member 11
Networked: 1051 relevant articles (20 outcomes, 110 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Terpos, Evangelos: 17 articles (11/2018 - 08/2003)
2. Dougall, William C: 16 articles (11/2018 - 11/2002)
3. Lewiecki, E Michael: 10 articles (11/2018 - 07/2006)
4. Kostenuik, Paul J: 9 articles (01/2018 - 10/2005)
5. Schwarz, Edward M: 8 articles (01/2021 - 03/2002)
6. Ueland, Thor: 8 articles (06/2010 - 07/2002)
7. Hofbauer, Lorenz C: 7 articles (01/2018 - 01/2002)
8. Aukrust, Pål: 7 articles (06/2010 - 05/2005)
9. Hofbauer, L C: 7 articles (01/2004 - 01/2000)
10. Udagawa, Nobuyuki: 6 articles (01/2022 - 01/2002)

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Osteoporosis
3. Bone Resorption
4. Neoplasms (Cancer)
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. Denosumab
2. Monoclonal Antibodies
3. Osteoprotegerin
4. Zoledronic Acid (Zometa)
5. Diphosphonates (Bisphosphonates)
6. Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)
7. Parathyroid Hormone (Parathormone)
8. Osteopontin
9. Cathepsin K
10. Estrogens (Estrogen)

Related Therapies and Procedures

1. Therapeutics
2. Ovariectomy (Oophorectomy)
3. Ligation
4. Hip Replacement Arthroplasty (Total Hip Replacement)
5. Retreatment