Member 25 Tumor Necrosis Factor Receptors

A tumor necrosis factor receptor subtype with specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15. It is found in tissues containing LYMPHOCYTES and may play a role in regulating lymphocyte homeostasis and APOPTOSIS. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Also Known As:

Receptors, Tumor Necrosis Factor, Member 25; Apo-3 Receptor; DR3 Receptor; Death Receptor 3; Lymphocyte Associated Receptor of Death Protein; TNFRSF25 Receptor; TRAMP Receptor; WSL-1 Protein; Apo 3 Receptor; Receptor, Apo-3; Receptor, DR3; Receptor, TNFRSF25; Receptor, TRAMP; WSL 1 Protein; Tumor Necrosis Factor Receptor Superfamily, Member 25

Networked: 50 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Death Domain Receptors: 2368
        Member 25 Tumor Necrosis Factor Receptors: 50
        human TNFRSF25 protein
        mouse Tnfrsf25 protein
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        Member 25 Tumor Necrosis Factor Receptors: 50
        human TNFRSF25 protein
        mouse Tnfrsf25 protein

Experts

1.	Wang, Eddie C Y: 6 articles (07/2019 - 03/2010)
2.	Cominelli, Fabio: 4 articles (01/2018 - 05/2006)
3.	Williams, Anwen S: 3 articles (07/2019 - 10/2014)
4.	Bamias, Giorgos: 3 articles (11/2016 - 05/2006)
5.	Al-Lamki, Rafia S: 2 articles (01/2022 - 01/2014)
6.	Herro, Rana: 2 articles (01/2021 - 11/2020)
7.	Soloff, Rachel: 2 articles (01/2021 - 11/2020)
8.	Meylan, Françoise: 2 articles (01/2020 - 01/2018)
9.	Richard, Arianne C: 2 articles (01/2020 - 01/2018)
10.	Siegel, Richard M: 2 articles (01/2020 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2018 - "Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells." 01/01/2012 - "Interleukin-32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3." 01/01/2022 - "Similar to the behavior of inflamed tubular epithelial cells, clear cell renal cell carcinoma (ccRCC) cells express death receptor 3 (DR3 or TNFSFR25) in situ, and expression increases with tumor grade. " 03/18/2005 - "We constructed a three-dimensional model of TNFRSF25 (death receptor-3; DR3), a tumor necrosis-receptor family member that is expressed on immune cells and on osteoblasts, to determine whether mutations that are linked to rheumatoid arthritis are likely to have effects on receptor function. " 01/14/1998 - "Two isoforms encoding the full-length transmembrane death receptor 3 (DR3) were isolated from mRNAs of a panel of human cell lines and tumor tissues obtained from patients with follicular non-Hodgkin's lymphoma. "
2.	Rheumatoid Arthritis 01/01/2018 - "A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell." 03/01/2006 - "Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells." 09/01/2004 - "Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis." 03/01/2006 - "To examine the promoter activity and protein expression of the death receptor 3 gene DR3, a member of the apoptosis-inducing Fas gene family, with particular reference to the methylation status of its promoter region in rheumatoid arthritis (RA). " 03/18/2005 - "We constructed a three-dimensional model of TNFRSF25 (death receptor-3; DR3), a tumor necrosis-receptor family member that is expressed on immune cells and on osteoblasts, to determine whether mutations that are linked to rheumatoid arthritis are likely to have effects on receptor function. "
3.	Autoimmune Diseases (Autoimmune Disease) 02/01/2010 - "Several lines of evidence both from experimental models and from clinical studies reveal that TNF-like ligand 1A (TL1A) and its interaction with death receptor 3 (DR3) is critically involved in the pathogenesis of rheumatoid arthritis and other autoimmune diseases." 07/01/2014 - "The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells and promotes diverse T cell-dependent models of autoimmune disease through its receptor DR3. " 10/01/2017 - "The Death Receptor 3 (DR3)/Tumour Necrosis Factor-like cytokine 1A (TL1A) axis stimulates effector T cells and type 2 innate lymphocytes (ILC2) that trigger cytokine release and drive disease pathology in several inflammatory and autoimmune diseases, including murine models of acute allergic lung inflammation (ALI). " 01/01/2020 - "The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). " 01/01/2014 - "Death receptor 3 (DR3; also designated as Wsl-1, Apo3, LARD, TRAMP, TNFRSF25, and TR3) is a member of the tumor necrosis factor (TNF) receptor superfamily that has emerged as a major regulator of inflammation and autoimmune diseases. "
4.	Uveitis 01/01/2011 - "This study investigated the role of death receptor 3 (DR3) in experimental autoimmune uveitis (EAU). "
5.	Osteoporosis 07/12/2019 - "Recent studies have revealed that the TNFSF members death receptor 3 (DR3) and one of its ligands, TNF-like protein 1A (TL1A) have a key role in secondary osteoporosis; enhancing CD14+ peripheral blood mononuclear cell (PBMC) osteoclast formation and bone resorption. "

Related Drugs and Biologics

1.	Ligands
2.	Proteins (Proteins, Gene)
3.	Caspase 8 (Caspase-8)
4.	cordycepin
5.	Cytokines
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
8.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
9.	NF-kappa B (NF-kB)
10.	Cyclin D2