Death Domain Receptors

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.

Also Known As:

Receptors, Death Domain; Death Receptors; Receptors, DR Family; Receptors, Death Domain Family; DR Family Receptors; Receptor, Death; Death Receptor

Networked: 2368 relevant articles (70 outcomes, 192 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Death Domain Receptors: 2368
        Type I Tumor Necrosis Factor Receptors: 1178
        TNF-Related Apoptosis-Inducing Ligand Receptors: 813
        fas Receptor: 763
        Member 25 Tumor Necrosis Factor Receptors: 50
        Edar Receptor: 13
        mouse Nradd protein

Experts

1.	El-Deiry, Wafik S: 14 articles (01/2021 - 04/2003)
2.	Krammer, Peter H: 14 articles (01/2018 - 02/2002)
3.	Fulda, Simone: 14 articles (01/2016 - 04/2002)
4.	Debatin, Klaus-Michael: 14 articles (05/2011 - 04/2002)
5.	Gajate, Consuelo: 13 articles (05/2021 - 08/2004)
6.	Mollinedo, Faustino: 13 articles (05/2021 - 08/2004)
7.	Walczak, Henning: 13 articles (01/2020 - 02/2002)
8.	de Jong, Steven: 13 articles (05/2012 - 08/2003)
9.	Zhou, Tong: 12 articles (01/2020 - 08/2002)
10.	Hong, Jin Tae: 12 articles (07/2017 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2009 - "HIFU-induced apoptosis in vivo and in vitro is one of the mechanisms for tumor control and is mediated by caspase 3, 8, and 9/6. The significantly greater activation of caspase 8 than of caspase 9/6 suggests that the apoptosis pathway induced by HIFU might be more mitochondria dependent than death receptor dependent. " 08/15/2001 - "Moreover, our data indicate that death receptor-mediated apoptosis has a more prominent role in the clearance of NK-sensitive tumors than previously suggested." 07/07/2019 - "Despite promising results from mice tumor models, TRAIL death receptor targeting has failed so far in clinical studies to show satisfying anti-tumor efficacy. " 04/01/2005 - "Together, our data suggest that simultaneous triggering of the death receptor and mitochondrial apoptotic pathways leads to enhanced induction of apoptosis, which makes it potentially useful for the treatment of resistant cancers." 07/01/2017 - "Finally, we conclude by stating that death receptor agonists may be improved through increasing their stability, solubility, and elimination half-life, as well as by overcoming the resistance of tumor cells. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/01/2022 - "The study revealed that the LPE induced the apoptosis of human non-small-cell lung cancer, A549 cells, either through mitochondrial or death receptor pathway." 01/01/2018 - "However, some non-small-cell lung carcinoma (NSCLC) patients are resistant to TRAIL treatment in clinical trials due to inactivation of the death receptors during cytoprotective autophagy. " 01/01/2020 - "Reliable predictive and prognostic markers are still lacking for patients treated with programmed death receptor 1 (PD1) inhibitors for non-small cell lung cancer (NSCLC). " 01/01/2019 - "The introduction of programmed death receptor ligand-1 (PD-L1) and programmed death receptor-1 (PD-1) inhibitors into the field of non-small cell lung cancer (NSCLC) was practice changing. " 03/01/2014 - "Here, we demonstrated the surprising finding that silencing of the SOX2 gene effectively induces apoptosis via the activation of death receptor and mitochondrial signaling pathways in human non-small cell lung cancer cells. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2018 - "The aim of the present study was to investigate the role of the endoplasmic reticulum stress and death receptor signaling pathways in PPI-induced apoptosis of human hepatocellular carcinoma HepG2 cells. " 08/01/2015 - "α-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation." 02/01/2015 - "The intrinsic apoptosis pathway, but not the death receptor pathway, contributed to the induction of apoptosis in hepatocellular carcinoma cells. " 07/15/2010 - "DeltaNp73beta is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria." 07/01/2010 - "ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria."
4.	Carcinoma (Carcinomatosis) 07/01/2011 - "Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells." 02/01/2010 - "The objective of the present study was to investigate whether apoptosis triggered by alpha-TOS in gastric carcinomas cells involves both mitochondria- and death receptor-dependent pathways. " 01/01/2014 - "Death receptor (DR4) haplotypes are associated with increased susceptibility of gallbladder carcinoma in north Indian population." 12/01/2012 - "fusiforme is involved in the induction of death receptor-associated apoptosis mediators in human gastric AGS carcinoma cells." 04/01/2012 - "Thus, these findings indicate that both the intrinsic pathway and the extrinsic death receptor pathway are involved in the process that silencing of the ILK gene induces the apoptosis in ovarian carcinoma SKOV3 cell."
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2020 - "CtBP determines ovarian cancer cell fate through repression of death receptors." 09/01/2018 - "Death receptor 6 promotes ovarian cancer cell migration through KIF11." 06/01/2016 - "The cell surface and transcript expressions of death receptors in parental chemosensitive (A2780) and their derivative chemoresistant (A2780-AD) ovarian cancer cells were determined by flow cytometry and quantitative real-time polymerase chain reaction, respectively. " 03/01/2015 - "Dkk-3 induces apoptosis through mitochondrial and Fas death receptor pathways in human mucinous ovarian cancer cells." 01/02/2015 - "Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells."

Related Drugs and Biologics

1.	Ligands
2.	Immune Checkpoint Inhibitors
3.	Monoclonal Antibodies
4.	Proteins (Proteins, Gene)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	CTLA-4 Antigen
7.	pembrolizumab
8.	Antibodies
9.	tigatuzumab
10.	Nivolumab

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Ligation
5.	Castration