Nocturnal Enuresis (Bedwetting)

07/01/2004 - "Alarms are the most effective treatment for nocturnal enuresis in children, but desmopressin may be considered for temporary relief."
02/01/2008 - "In this issue Ferrara et al. present an important placebo-controlled, three-arm, double-blind, double-dummy, study on the treatment of nocturnal enuresis, demonstrating that homotoxicology is superior to placebo but less effective than desmopressin. "
07/01/2004 - "The study included 259 children suffering from PNE (92 girls, 167 boys, aged 5-18 years): 42 children were relieved from bedwetting after urotherapy and 136 children had a complete response to desmopressin. "
08/01/2015 - "Although desmopressin therapy is effective in treating polyuric monosymptomatic nocturnal enuresis (MNE), the relatively high rates of recurrence are problematic. "
01/01/2015 - "The overall findings from the eight studies showed that long term alarm therapy was more effective in treating nocturnal enuresis than desmopressin therapy. "

09/01/1992 - "In children, the drug is prescribed most frequently (56%) for conditions outside the licensed indications, particularly nocturnal enuresis, a condition for which the efficacy of Ditropan has not been established. "
05/01/2011 - "Oxybutynin is an anticholinergic drug that has not been proven to be effective for treatment of nocturnal enuresis not accompanied by daytime symptoms, such as urgency. "
05/01/2011 - "Is oxybutynin a safe and effective drug for treating nocturnal enuresis? "
05/01/2011 - "Oxybutynin for treatment of nocturnal enuresis in children."
11/01/2007 - "In the treatment of children with monosymptomatic nocturnal enuresis maximum voided volume can be increased significantly through holding exercises, but not with oxybutynin chloride alone. "

01/01/1999 - "Imipramine therapy was given to 10 of the 17 patients with symptoms of urinary frequency, urgency and nocturnal enuresis with a significantly symptomatic improvement in 9 of these patients. "
09/01/2009 - "On the other hand, if the anti-enuretic effect of imipramine is primarily due to its action on the CNS, a form of imipramine that cannot pass through the BBB has no effect on nocturnal enuresis treatment and thus may help to clarify the mechanism of action of imipramine in nocturnal enuresis treatment. "
06/01/1997 - "Nocturnal enuresis was observed in 4 children who responded favorably to imipramine hydrochloride therapy. "
04/01/1996 - "The aim of this study was to investigate any existing urinary or serum factor differences between 9 children with primary nocturnal enuresis and six age and sex matched controls and to see if therapy with Imipramine could modify these parameters. "
01/01/1985 - "Since imipramine has a beneficial effect in the treatment of nocturnal enuresis, the present study was carried out to investigate a possible association between alteration in 3H-imipramine binding parameters in enuretics in comparison to nonenuretic control subjects. "

12/01/2013 - "Anti-diuretic hormone and genetic study in primary nocturnal enuresis."
08/01/2006 - "The study suggests that an abnormally large nocturnal excretion of Na caused by selectively attenuated circadian rhythms of Na regulating hormones might be an important pathogenic factor in monosymptomatic nocturnal enuresis."
12/01/2013 - "To investigate whether primary nocturnal enuresis (PNE) is related to a disturbance in anti-diuretic hormone (ADH) secretion pattern at night which may be genetically inherited. "
06/01/2010 - "To elucidate the background behind the attenuated circadian rhythm of vasoactive hormones in patients with nocturnal enuresis, we tested the hypothesis that enuretic children exhibit an abnormal neuroendocrine response to a baroreflex stimulus during daytime. "
08/01/2006 - "We investigated the circadian rhythm of solute excretion and regulating hormones as well as blood pressure in patients with monosymptomatic nocturnal enuresis. "

02/01/1986 - "The results showed that diclofenac sodium was significantly more effective than placebo in the treatment of nocturnal enuresis."
02/01/1986 - "The prostaglandin synthesis inhibitor diclofenac sodium has been compared with a placebo in the treatment of primary nocturnal enuresis in a double-blind crossover trial. "
09/01/1995 - "A prostaglandin synthesis inhibitor, diclofenac sodium in the treatment of primary nocturnal enuresis."
01/01/1992 - "The statistically significant difference in response to diclofenac sodium and to placebo leads us to use diclofenac sodium in primary nocturnal enuresis."
01/01/1992 - "The prostaglandin synthesis inhibitor diclofenac sodium was given as suppository in the treatment of primary nocturnal enuresis in 24 patients. "

04/01/1996 - "We therefore conclude that pseudoephedrine can be an alternative in the treatment of primary nocturnal enuresis."
05/01/2009 - "This exploratory randomized, double-blind, double-dummy, placebo-controlled trial of 14 days duration conducted in 22 primary care practices in the United States was used to compare the efficacy of ibuprofen and pseudoephedrine, administered alone or in combination, to placebo for the treatment of primary nocturnal enuresis (PNE) in children aged 6 to 11 years. "
05/01/2009 - "A randomized, placebo-controlled, exploratory trial of Ibuprofen and pseudoephedrine in the treatment of primary nocturnal enuresis in children."
02/01/2011 - "The additive pharmacologic effects of imipramine with pseudoephedrine for the treatment of monosymptomatic nocturnal enuresis in children were well tolerated, and gave significantly faster results than single drug therapy using imipramine. "
04/01/1996 - "The efficacy of oxybutynin, pseudoephedrine and indomethacin treatment was investigated in 29 patients with primary nocturnal enuresis. "

09/01/1998 - "Not all children with primary nocturnal enuresis, an unstable detrusor and small bladder capacity can be treated successfully with anticholinergics and bladder drill. "
03/01/2011 - "Anticholinergics do not improve cure rate of alarm treatment of monosymptomatic nocturnal enuresis."
03/01/2011 - "Switching from previous anticholinergic treatment that has failed to alarm treatment or using a combination of alarm treatment and anticholinergics did not improve the functional bladder volume or cure rate of children with monosymptomatic nocturnal enuresis."
03/01/2011 - "To determine whether previous anticholinergic therapy or a combination of anticholinergics and alarm treatment could increase the success rates for monosymptomatic nocturnal enuresis. "
03/01/2011 - "Anticholinergics do not improve cure rate of alarm treatment of monosymptomatic nocturnal enuresis."

02/01/1997 - "Desmopressin tablets are an effective and safe alternative for treatment of nocturnal enuresis."
08/01/2015 - "This study is a re-analysis of a prospective, open-label, multinational, phase-IV study evaluating ≤6 months of treatment with desmopressin tablets for children with primary nocturnal enuresis. "
02/01/1994 - "A dose titration, and an open 6-week efficacy and safety study of desmopressin tablets in the management of nocturnal enuresis."
07/01/1987 - "A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis. "
10/01/2009 - "This was a substudy of an international investigation of treatment for 6 months or less with desmopressin tablets in children with primary nocturnal enuresis. "

01/01/2013 - "This study compares the combined Desmopressin and Tolterodine efficacy versus Desmopressin alone efficacy in the treatment of nocturnal enuresis. "
01/01/2013 - "Does combination therapy with desmopressin and tolterodine improve the treatment outcomes of patients with monosymptomatic nocturnal enuresis? "
01/01/2005 - "Twenty children with diurnal and nocturnal enuresis were given desmopressin and oxybutinine or desmopressin and tolterodine. "
07/01/2001 - "This is the first published report of using tolterodine to treat clozapine-induced nocturnal enuresis. "
07/01/2001 - "To report the use and subsequent failure of the bladder-selective agent tolterodine, to treat clozapine-induced nocturnal enuresis in an adolescent patient with psychotic illness. "

11/01/1987 - "Nocturnal enuresis was observed in 4 patients, 3 of whom responded favorably to I-desamino-8-D-arginine vasopressin therapy. "
01/01/2007 - "Measurements of urinary vasopressin and osmolality were made pre- and post-alarm treatment in a group (n=12) of outpatient children (aged 7-12 years) with severe (more than four times a week) nocturnal enuresis. "
11/01/2006 - "Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis."
08/01/2000 - "This paper proposes a model based on the notion that nocturnal enuresis arises through the ill functioning of one or more of the following three systems - a lack of vasopressin release during sleep; bladder instability; and/or an inability to arouse from sleep to bladder sensations. "
05/01/1999 - "Plasma vasopressin and response to treatment in primary nocturnal enuresis."

02/01/2006 - "Is a combination of alarm and drug therapies effective in nocturnal enuresis?"
05/01/2014 - "Role of Urodynamic Study in Nocturnal Enuresis: Urodynamic Findings and Treatment Outcome Correlation in Children with Pharmacotherapy-resistant Monosymptomatic Nocturnal Enuresis or Severe Non-monosymptomatic Nocturnal Enuresis."
04/01/2012 - "This group (non-monosymptomatic nocturnal enuresis) requires a different clinical approach, with a focus on treating daytime bladder symptoms, which commonly involves pharmacotherapy with anticholinergic medications and urotherapy (including addressing bowel problems). "
01/01/2007 - "We aimed at comparing the success rates of primary enuretic alarm therapy with those of secondary alarm therapy after failed pharmacotherapy in the treatment of monosymptomatic nocturnal enuresis (MNE). "
01/01/2007 - "Is second-line enuretic alarm therapy after unsuccessful pharmacotherapy superior to first-line therapy in the treatment of monosymptomatic nocturnal enuresis?"

06/01/1998 - "A previous retrospective study of 10 children with varying degrees of nocturnal enuresis has shown that one side effect of rapid maxillary expansion (RME) is spontaneous reduction in bed-wetting at night. "
01/01/2014 - "The purpose of this study was to evaluate the therapeutic and placebo effects of slow maxillary expansion on nocturnal enuresis. "
01/01/1990 - "In the ten cases examined in this study, nocturnal enuresis ceased within a few months of maxillary expansion."
01/01/2015 - "Influence of Orthodontic Rapid Maxillary Expansion on Nocturnal Enuresis in Children."
01/01/2015 - "Effect of rapid maxillary expansion on monosymptomatic primary nocturnal enuresis."

07/01/2004 - "Laser acupuncture is a painless, non-invasive, and cost effective treatment for children with therapy resistant monosymptomatic nocturnal enuresis. "
05/01/2011 - "Laser acupuncture is a safe but inefficient treatment for monosymptomatic nocturnal enuresis with reduced maximal voided volume. "
05/01/2011 - "Effect of laser acupuncture for monosymptomatic nocturnal enuresis on bladder reservoir function and nocturnal urine output."
07/01/2004 - "[Laser acupuncture as third-line therapy for primary nocturnal enuresis. "
05/01/2011 - "In our study the effect of laser acupuncture therapy on patients with primary monosymptomatic nocturnal enuresis was evaluated in a prospective, randomized, placebo controlled, single-blind study. "

01/01/2015 - "Clinical researches about acupuncture therapy for nocturnal enuresis are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking. "
01/01/2015 - "This study aims to assess the effectiveness of acupuncture therapy for nocturnal enuresis. "
02/01/2001 - "Acupuncture therapy in the management of persistent primary nocturnal enuresis--preliminary results."
05/01/2011 - "In our study the effect of laser acupuncture therapy on patients with primary monosymptomatic nocturnal enuresis was evaluated in a prospective, randomized, placebo controlled, single-blind study. "
09/01/2013 - "Acupuncture Therapy; Nocturnal Enuresis; Traditional Medicine."

08/01/2008 - "This study examined the sustainability of remission of primary nocturnal enuresis (PNE) using an algorithm-based multimodal treatment plan, Try for Dry. "