Urge Urinary Incontinence (Urge Incontinence)

Involuntary discharge of URINE that is associated with an abrupt and strong desire to void. It is usually related to the involuntary contractions of the detrusor muscle of the bladder (detrusor hyperreflexia or detrusor instability).

Also Known As:

Networked: 581 relevant articles (69 outcomes, 94 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Overactive Urinary Bladder (Overactive Bladder)
2.	Nocturia
3.	Urinary Incontinence
4.	Urge Urinary Incontinence (Urge Incontinence)
5.	Dysuria

Experts

1.	Amundsen, Cindy L: 8 articles (07/2011 - 09/2002)
2.	Brubaker, Linda: 7 articles (05/2014 - 07/2008)
3.	Richter, Holly E: 7 articles (01/2012 - 11/2002)
4.	Dmochowski, Roger R: 7 articles (02/2010 - 06/2003)
5.	Goode, Patricia S: 6 articles (10/2010 - 11/2002)
6.	Jonas, U: 6 articles (01/2005 - 05/2000)
7.	Griffiths, Derek: 5 articles (09/2015 - 03/2003)
8.	Resnick, Neil M: 5 articles (09/2015 - 03/2003)
9.	Cardozo, Linda: 5 articles (01/2011 - 06/2003)
10.	Burgio, Kathryn L: 5 articles (10/2010 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Urge Urinary Incontinence:

1.	oxybutynin (Tavor)FDA LinkGeneric 01/01/2005 - "Although most novel anticholinergic medications are effective and well tolerated in children, in our experience oxybutynin extended release provides superior relief for urge urinary incontinence in children. " 06/01/1990 - "We found oxybutynin chloride significantly more effective than placebo at reducing the symptoms of urgency and urge incontinence and more effective at reducing the height of the highest unstable detrusor contraction. " 12/01/2003 - "Although oral oxybutynin has been effective in controlling urinary urge incontinence and in decreasing incontinence episodes, adverse events, particularly dry mouth, often cause patients to discontinue oral therapy and to endure incontinence. " 10/01/2005 - "Data were combined from 3 flexible dosing studies of a total of 420 patients with urge urinary incontinence or mixed incontinence in whom ER oxybutynin dose adjustments were made to achieve the optimal balance between efficacy and tolerability, as judged by each participant. " 10/01/2005 - "Efficacy and safety of extended release oxybutynin for the treatment of urge incontinence: an analysis of data from 3 flexible dosing studies."
2.	tolterodine (Detrol)FDA Link 04/01/2002 - "After 1 week, tolterodine ER 4 mg had produced a significant improvement in all efficacy variables in both groups of patients (P < 0.01); 72% of the maximum effect on urge incontinence was observed in both groups; and 84.7% of drug-naive patients and 83.6% of previously treated patients perceived a benefit from treatment. " 10/01/2001 - "The advent of a new extended-release (ER) capsule formulation of tolterodine (4 mg) for convenient once-daily treatment builds upon these findings, with significantly improved efficacy for reducing urge incontinence episodes and a lower frequency of dry mouth relative to the existing IR tablet (2 mg b.i.d.). " 09/01/2003 - "Tolterodine is equally effective in patients with mixed incontinence and those with urge incontinence alone." 10/01/2001 - "A single trial found tolterodine extended-release 4 mg/day to have improved efficacy for decreasing urge incontinence episodes along with lower frequency of dry mouth vs. immediate-release tolterodine 2 mg bid. " 08/01/2004 - "The efficacy of tolterodine ER in reducing urge incontinence episodes was unaffected by the presence of stress incontinence. "
3.	propiverineIBA 03/01/2003 - "These findings were confirmed by the overall assessment after four weeks in which approximately 90 % of patients under propiverine were either free from urge incontinence and urge symptoms or improved. " 06/01/2000 - "These findings were confirmed by the overall assessment at V4, in which approximately 90% of patients under propiverine either had no urge incontinence or urge symptoms, or showed improvement. " 01/01/1998 - "These results suggest that propiverine hydrochloride is a safe and effective drug of choice for the treatment of not only urge incontinence but also stress incontinence in patients diagnosed in a clinical setting." 09/01/1995 - "The results suggest that propiverine is a safe and effective drug for the treatment of urgency and urge incontinence. " 03/01/2003 - "The efficacy of propiverine in elderly patients suffering from urge incontinence or urge-stress incontinence was intended to be investigated. "
4.	quinuclidin- 3'- yl- 1- phenyl- 1,2,3,4- tetrahydroisoquinoline- 2- carboxylate monosuccinate (solifenacin)FDA Link 08/01/2014 - "Solifenacin 5mg once daily improved urgency and other symptoms of OAB including frequency, urge incontinence, OABSS and International Prostatic Symptom Score. " 03/01/2005 - "In patients randomised to solifenacin in the double-blind studies, there were small incremental improvements in all efficacy parameters (reductions in episodes per 24 hours of urgency, reductions in frequency and urge incontinence, and increases in volume voided per micturition) over the course of the extension study. " 06/01/2013 - "Compared to the control group, solifenacin group had significantly lower total symptom score, urgency and urge incontinence scores. " 01/01/2010 - "Therapy with Solifenacin 5 and 10 mg has alleviated urgency in 82% and urge-incontinence in 88.9%. " 03/01/2007 - "Patients reporting urge incontinence as their most bothersome OAB symptom can be expected to demonstrate significant improvements in multiple patient-related outcomes following treatment with flexibly dosed solifenacin."
5.	fesoterodineFDA Link 01/01/2009 - "black triangle In two large, 12-week, randomized, double-blind, multicentre, phase III trials, oral fesoterodine 4 or 8 mg once daily improved the symptoms of OAB (frequency of micturition, urgency and urge incontinence) significantly more than placebo. " 02/01/2010 - "As many as 60% of patients actively treated with fesoterodine reported no urge urinary incontinence episodes on a 3-day voiding diary, a significant improvement over placebo. " 06/01/2015 - "Prospective trials in specific patient populations indicated beneficial effects of fesoterodine in elderly patients, vulnerable elderly patients, patients dissatisfied with or with a suboptimal response to previous antimuscarinic therapy, patients with urge urinary incontinence (UUI) or nocturnal urgency, and men with persistent LUTS during alpha-blocker treatment. " 02/01/2010 - "In two phase III studies, fesoterodine has been shown to significantly reduce mean urgency and urge urinary incontinence (UUI) episodes over placebo. " 10/01/2010 - "In two 12-week, randomized, multicenter, Phase III clinical trials involving patients with increased micturition frequency and urgency and/or urinary urge incontinence (n = 836 and 1132 in each trial), both fesoterodine 4 and 8 mg were associated with significantly improved symptoms of OAB (frequency of micturition, urgency, and urge incontinence) compared with placebo (P < 0.05). "
6.	Estrogens (Estrogen)FDA Link 05/01/2005 - "The sensation of urgency improves with estrogen but urge incontinence improvement is similar to that with placebo. " 08/01/1997 - "Evaluation of historic, examination, and urinary diary data for their influences on the predictive value of pure stress incontinence or urge incontinence revealed statistical differences for urethral hypermobility, estrogen deficiency, and incontinent episodes, yet they were not clinically practical predictors. " 11/01/1992 - "Our results confirm the value of topical estrogen application as a cornerstone of efficient treatment of stress and/or urge incontinence in the postmenopausal patient." 01/01/1992 - "In climacteric women stress and urge incontinence often occur as a consequence of estrogen deficiency. " 01/01/1990 - "[Treatment of female urge incontinence by local estrogen therapy]."
7.	Muscarinic AntagonistsIBA 05/01/2013 - "Antimuscarinics are the only drugs that have demonstrated efficacy and safety in urge urinary incontinence (UUI) and OAB. " 05/01/2013 - "Antimuscarinics are the only drugs that have demonstrated efficacy and safety in urge urinary incontinence (UUI) and OAB. " 06/01/2012 - "Simultaneous use of 2 different antimuscarinics to treat refractory urge urinary incontinence. " 06/01/2012 - "Simultaneous use of 2 different antimuscarinics to treat refractory urge urinary incontinence. " 02/15/2008 - "Finally, urge urinary incontinence is more often treated with antimuscarinic agents. "
8.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2010 - "Based on the results of this study we can conclude that treatment of patients with urge urinary incontinence not responding to classical anticholinergic treatment with botulinum toxin causes a significant improvement in the quality of their life." 01/01/2012 - "We present the rationale and design of a randomized-controlled trial, Anticholinergic versus Botulinum Toxin, Comparison Trial for the Treatment of Bothersome Urge Urinary Incontinence: ABC trial, conducted by the NICHD-funded Pelvic Floor Disorders Network. " 01/01/2012 - "Anticholinergic versus botulinum toxin A comparison trial for the treatment of bothersome urge urinary incontinence: ABC trial." 07/01/2008 - "This institutional review board approved, multicenter registered trial randomized women with refractory urge incontinence, detrusor overactivity incontinence and 6 or greater urge incontinence episodes in 3 days to botulinum toxin A or placebo at a 2:1 ratio. " 12/01/2014 - "The effects of lipo-botulinum toxin on urinary urge incontinence were inconclusive. "
9.	Estradiol (Estrace)FDA LinkGeneric 06/01/2003 - "Subjectively there was a significant improvement in urgency in both groups and urge incontinence in the estradiol group, but no significant differences between the groups. " 12/01/2011 - "Similarly, estradiol levels were not associated with the worsening of any (odds ratio, 1.00; 95% CI, 0.99-1.01), stress, or urge incontinence in incontinent women. " 12/01/2011 - "Estradiol levels drawn at either the annual visit concurrent with or previous to the first report of incontinence were not associated with the development of any (hazard ratio, 0.99; 95% CI, 0.99-1.01), stress, or urge incontinence in previously continent women. " 12/01/2011 - "We evaluated the relationship between annually measured serum endogenous estradiol and the development or worsening of stress and urge incontinence symptoms during a period of 8 years in women transitioning through menopause. " 11/01/2011 - "To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. "
10.	Cholinergic Antagonists (Anticholinergics)IBA 10/01/1992 - "These findings suggested that FES was very useful for the treatment of urge incontinence, with its efficacy augmented by the administration of anticholinergic agents." 05/01/2003 - "Anticholinergics are primarily indicated if urge symptoms/incontinence persist after obstruction has been relieved or if urge incontinence occurs without obstruction. " 07/01/2013 - "The place in therapy of mirabegron relative to anticholinergics in the treatment of urge incontinence has not yet been established." 12/01/2011 - "Eight girls and five boys, aged 7-19 years, who had urge incontinence refractory to scheduled voiding and anticholinergics, were included this prospective study. " 10/01/2009 - "We recruited 27 children 5 to 14 years old with daytime urge incontinence refractory to timer assisted standard urotherapy and anticholinergics who had normal urinalysis, and unremarkable urinary tract ultrasound and physical examination. "

Therapies and Procedures

1.	Injections 03/01/2012 - "Three months after the procedure, we observed>50% improvement versus baseline in urgency and urge urinary incontinence (UUI) in 65% and 56% of patients who respectively received 100 U (p=0.086) and 150 U (p=0.261) BoNTA injections and >75% improvement in 40% of patients of both groups (100 U [p=0.058] and 150 U [p=0.022]). " 11/01/2011 - "Retrospective chart review was performed on all patients undergoing intradetrusor BTX-A (BOTOX®, Allergan Inc., Irvine, CA) injections from 2004 to 2010 for the management of refractory idiopathic OAB with or without urge incontinence. " 05/01/2005 - "Urge urinary incontinence decreased 4 weeks after the BTX-A injections. " 01/01/2001 - "Complications included cystitis in 9 of 189 injections, urinary retention in 6 in the fat injection group, urge incontinence in 9 of 68 patients and pulmonary fat embolism resulting in death in 1 of 189 procedures. " 01/01/2013 - "Efficacy of botulinum toxin a intradetrusor injections for non-neurogenic urinary urge incontinence: a randomized double-blind controlled trial."
2.	Aftercare (After-Treatment) 05/01/2006 - "However, there were no significant differences in the data before and after treatment within all subgroups (stress incontinence, urge incontinence, urgency/frequency, defecation problems, overactive pelvic floor, age, previous treatments), except for the KHQ domain of 'role limitations', where there was a significant improvement in all groups. " 02/01/2015 - "Outcome was defined as a score of 1 or less for questions 2 and 3 on the six-item Urodynamic Distress Inventory (UDI-6) and seven-item Incontinence Impact Questionnaire, in addition to clinical symptomatic improvement with no urgency, urge incontinence and voiding frequency of less than eight times per 24 h on a 3-day bladder diary after treatment. " 01/01/1993 - "In this study we urodynamically examined 105 women suffering from urge incontinence before and 4 weeks after treatment with various drugs. " 06/01/2014 - "Positive changes in urinary urgency, Frequency and Urge incontinence after treatment in both groups were seen but mean improvements in the all were larger in the patients who treated by oxybutinin especially in terms of urgency and Urge incontinence. " 09/15/2012 - "At 2 years after treatment, only 1.8% of men required a pad for urge incontinence. "
3.	Catheters 01/01/2012 - "After catheter removal at 2 weeks, 18 patients (85 %) remained dry while one patient experienced urge incontinence, which resolved in a few days and another one still had urine leakage (although less than before the operation) that improved after another 3 weeks of bladder drainage. " 10/01/2004 - "After removal of the urethral catheter, urge incontinence was recognized, but it improved gradually. " 12/01/2000 - "After removal of the catheter, 4 of the 20 patients suffered stress and urge incontinence with the use of 1 pad a day. " 03/01/2014 - "However, following catheter removal on the fifth postoperative day, she developed urge incontinence due to urinary tract infection. " 05/01/2011 - "There were no major postoperative complications, but urge incontinence (16 cases) and dysuria (33 cases) occurred after removal of the urethral catheter. "
4.	Drug Therapy (Chemotherapy) 11/01/2002 - "Although behavioral and drug therapies are known to be highly effective for reducing urge incontinence, few patients are cured with either treatment alone. " 11/01/2002 - "To review the efficacy of drug therapy for urinary urge incontinence by examining the published literature. " 01/01/2004 - "For pharmacotherapy of urge incontinence, older age, female gender, and greater incontinence severity were associated with poorer outcomes in 1 study. " 01/01/2004 - "However, only pharmacotherapy for urge incontinence has advanced to the level at which several drugs that have undergone rigorous scientific testing using randomized controlled trials have received FDA approval; these are the antimuscarinic and anticholinergic/direct smooth muscle relaxant drugs. " 11/01/2002 - "In October 1999, we searched the medical databases MEDLINE, EMBASE, and Cochrane Controlled Trials Register to identify prospective randomized, double-blind, placebo-controlled clinical trials in the English literature evaluating drug therapy (except hormonal therapy) of urinary urge incontinence. "
5.	Home Nursing (Nursing, Home) 06/01/1995 - "Seventy-five nursing home residents with predominantly urge incontinence, whose incontinence did not respond well to a trial of PV. The frequency of incontinence, measured as the percentage of hourly (7 AM to 7 PM) physical checks over a 3-day period at which the resident was found wet. " 04/01/2010 - "Faecal incontinence affects 14% of female and 6% of male nursing home residents in Turkey, and urge incontinence is common." 01/01/2001 - "Among elderly nursing home patients, Oxy-XL achieved a 90% reduction in weekly urge incontinence episodes and an 86% decrease in pad use. " 07/01/2012 - "Re: Efficacy of oral extended-release oxybutynin in cognitively impaired older nursing home residents with urge urinary incontinence: a randomized placebo-controlled trial." 11/01/2011 - "Efficacy of oral extended-release oxybutynin in cognitively impaired older nursing home residents with urge urinary incontinence: a randomized placebo-controlled trial."