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Fas-Associated Death Domain Protein (Fas-Associating Protein with Death Domain)

A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.
Also Known As:
Fas-Associating Protein with Death Domain; FADD Protein, Fas-Associating; Fas Associated Death Domain Protein; Fas-Associating Protein FADD; MORT1 Protein; FADD Protein, Fas Associating; FADD, Fas-Associating Protein; Fas Associating Protein FADD; Fas Associating Protein with Death Domain; Fas-Associating FADD Protein
Networked: 47 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Yang, Xiao: 2 articles (01/2009 - 11/2007)
2. De La Cruz, Arielle: 1 article (01/2022)
3. El-Deiry, Wafik S: 1 article (01/2022)
4. Finnberg, Niklas K: 1 article (01/2022)
5. Fox, Jennifer T: 1 article (01/2022)
6. Glaze, Elizabeth R: 1 article (01/2022)
7. Hacking, Sean: 1 article (01/2022)
8. Madka, Venkateshwar: 1 article (01/2022)
9. Panneerselvam, Janani: 1 article (01/2022)
10. Pathuri, Gopal: 1 article (01/2022)

Related Diseases

1. Sarcoma (Soft Tissue Sarcoma)
2. Neoplasms (Cancer)
01/01/2022 - "Molecular analysis of the tumors suggested an increase in TRAIL, DR5, cleaved caspases 3/7/8, Fas-associated death domain protein (FADD), and p21 (WAF1) in response to drug treatment. "
07/01/2006 - "An aim of the study was to determine the protein expression of the FAS-related apoptosis signaling pathway (FADD-FAS Associating Protein with Death Domain, PRO-CASPASE-8 and CASPASE-8), which are responsible for signal transduction to trigger programmed cell death (apoptosis) in cancer and Prostatic Intraepitelial Neoplasia (PIN). "
01/01/2017 - "Signaling associated with apoptosis was suppressed in tumor-initiating versus nontumorigenic counterparts with pro-apoptotic proteins, such as Bcl2-associated agonist of cell death (BAD), FAS-associated death domain protein (FADD), and myeloid differentiation primary response protein (MYD88), downregulated in tumor-initiating epithelial-like cells. "
01/01/2009 - "We investigated whether the phosphorylated Fas-associated death domain protein (FADD) at serine 194 regulated human telomerase reverse transcriptase (hTERT) expression, telomerase activity and cancer progression using prostate cancer cell lines and radical prostatectomy samples taken from patients receiving neoadjuvant hormonal therapy (NHT). "
08/01/2011 - "The mean percentage of serine 194 phosphorylated Fas-associated death domain protein positive tumor cells was 81% in Burkitt lymphoma, 41% in diffuse large B-cell lymphoma, 18% in follicular lymphoma, 18% in plasma cell myeloma, 12% in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, 11% in mantle cell lymphoma, and 2% in chronic lymphocytic leukemia/small lymphocytic lymphoma (P < .0001, Kruskal-Wallis test). "
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Seizures (Absence Seizure)
5. Pancreatic Neoplasms (Pancreatic Cancer)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Enzymes
3. Interleukin-1beta (Interleukin 1 beta)
4. Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
5. JNK Mitogen-Activated Protein Kinases
6. MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)
7. Mitogen-Activated Protein Kinases
8. Caspase 8 (Caspase-8)
9. Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
10. Caspases

Related Therapies and Procedures

1. Therapeutics
2. Prostatectomy (Retropubic Prostatectomy)