TNF Receptor-Associated Death Domain Protein

A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yang, Xiao: 2 articles (01/2009 - 11/2007)
2.	Jiang, Haili: 1 article (01/2021)
3.	Liu, Yong: 1 article (01/2021)
4.	Liu, Zhaohui: 1 article (01/2021)
5.	Lu, Chang: 1 article (01/2021)
6.	Wang, Xiaodan: 1 article (01/2021)
7.	Chung, Ji Hyung: 1 article (07/2015)
8.	Hahm, Soo-Hyun: 1 article (07/2015)
9.	Han, Se Hee: 1 article (07/2015)
10.	Han, Ye Sun: 1 article (07/2015)

Related Diseases

1.	Endometriosis 01/01/2021 - "The aim of current study was to explore the role of tumor necrosis factor receptor type 1-associated death domain (TRADD) protein in endometriosis. "
2.	Necrosis 05/06/2012 - "Tumour necrosis factor receptor (TNFR)-associated death domain (TRADD) protein is a central adaptor in the TNFR1 signalling complex that mediates both cell death and inflammatory signals. " 07/01/2015 - "The TNF receptor-associated death domain (TRADD) protein is recruited to the death domain of TNF receptor 1 (TNFR1), where it interacts with TNF receptor-associated factor 2 (TRAF2) and receptor-interacting protein (RIP) for the induction of apoptosis, necrosis, nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and mitogen-activated protein (MAP) kinase activation. "
3.	T-Cell Leukemia (Leukemia, T Cell) 06/28/1999 - "Moreover, NF-kappaB activation induced by overexpression of the TNF receptor-associated proteins TNF receptor-associated death domain protein (TRADD), receptor interacting protein (RIP), and TNF recep- tor-associated factor 2 (TRAF2) was also inhibited by expression of A20, whereas NF-kappaB activation induced by overexpression of NF-kappaB-inducing kinase (NIK) or the human T cell leukemia virus type 1 (HTLV-1) Tax was unaffected. "
4.	Neoplasms (Cancer) 07/07/2005 - "Expressions of the FADD, FasL, Fas, and NFkappaB proteins reduced with increase of the volume of tumor with the exception of increased expression the TRADD protein (64.7-71.1%, P = 0.031). "
5.	Lupus Nephritis 01/01/2009 - "To investigate the mRNA expressions of the TNF adapter proteins, including TNF receptor-associated death domain protein (TRADD), Fas-associated death domain protein (FADD), receptor-interacting protein 1 (RIP-1) and TNF receptor-associated factor-2 (TRAF-2) in peripheral blood mononuclear cells (PBMCs) of lupus nephritis (LN) patients of various TCM asthenia syndromes. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
2.	Proteins (Proteins, Gene)
3.	Receptor-Interacting Protein Serine-Threonine Kinases
4.	Fas-Associated Death Domain Protein (Fas-Associating Protein with Death Domain)
5.	TNF Receptor-Associated Factor 2 (TRAF2)
6.	Type I Tumor Necrosis Factor Receptors
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Messenger RNA (mRNA)
9.	Membrane Proteins (Integral Membrane Proteins)
10.	Tumor Necrosis Factor Receptor-Associated Peptides and Proteins