Caspase 8 (Caspase-8)

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Also Known As:

Networked: 2442 relevant articles (47 outcomes, 219 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Green, Douglas R: 13 articles (01/2020 - 10/2002)
2.	Trautwein, Christian: 13 articles (12/2018 - 06/2003)
3.	Longley, Daniel B: 12 articles (01/2022 - 06/2007)
4.	Liedtke, Christian: 12 articles (04/2019 - 06/2003)
5.	Zhang, Jing: 10 articles (01/2022 - 09/2006)
6.	Kanneganti, Thirumala-Devi: 10 articles (11/2021 - 01/2015)
7.	Hao, Chunhai: 10 articles (02/2012 - 07/2002)
8.	Walczak, Henning: 9 articles (10/2021 - 07/2007)
9.	Mocarski, Edward S: 9 articles (08/2019 - 10/2013)
10.	Sun, Shi-Yong: 9 articles (01/2017 - 10/2007)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2008 - "Cotreatment of mice with DATS and TRAIL was more effective in inhibiting prostate tumor growth and inducing DR4 and DR5 expression, caspase-8 activity, and apoptosis than either agent alone. " 01/24/2022 - "Studies in cancer cell lines demonstrated that the intracellular accumulation of TRAIL receptor-2 (TRAIL-R2) and the subsequent activation of caspase-8 contribute significantly to apoptosis induction upon ER stress. " 10/01/2021 - "Therefore, it is very important to measure the cancer-promoting and anticancer effects of caspase-8 and find a balance, and to study its role in the effect of "PANoptosis" in depth. " 10/01/2021 - "With the continuous exploration of the types of programmed cell death, an increasing number of studies have confirmed that caspase-8 plays an important role in cancer. " 04/12/2012 - "In the present study, we report that the loss of caspase-8 in B lymphocytes leads to B-cell malignancies and that the risk for these tumors is further enhanced in the absence of p53. "
2.	Ischemia 01/01/2020 - "Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation." 10/01/2017 - "These results suggested that hypothalamus and midbrain are more vulnerable to ischemia, and endogenous cPKCγ affects the regional ischemic vulnerability through modulating Caspase-8 and -9 dependent cell apoptosis." 01/29/2008 - "Our findings suggest a possible association between expression of FADD, caspase-8, Daxx and FAP-1 genes and apoptosis following ischemia." 11/01/2004 - "Regarding cell death by apoptosis, although ischemia did increase caspase-8-like activity, there were no changes in caspase-3-like activity, which is activated downstream of caspase-8; this may indicate that the apoptotic cascade is not activated by 60 minutes of ischemia. " 04/01/2001 - "After transient focal ischemia in mice, Par-4 levels were increased 6 to 12 hours after reperfusion in the infarcted cortex and the striatum, and activation of caspase-8 occurred with a similar time course. "
3.	Inflammation (Inflammations) 01/01/2021 - "In light of diverse functions of caspase-8 in apoptosis, cell survival, and inflammation, this study investigated the importance of caspase-8 in different fates of glaucomatous RGCs and astroglia using two experimental approaches in parallel. " 01/01/2020 - "The aim of our study is to investigate the clinical application of pharmacological inhibition of caspase-8 and the underlying molecular mechanisms in inflammation-induced angiogenesis in the cornea. " 01/01/2015 - "Studies on multiple double- and triple- knockout mice identified caspase-8, flip, and fadd genes as key regulators of embryonic lethality and inflammation. " 12/01/2023 - "However, caspase 8, in particular, also has additional nonapoptotic roles, such as in inflammation. " 12/01/2023 - "Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation."
4.	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/09/2022 - "Conclusion: Increased caspase-8 and CDK9 levels correlate with improved disease-related outcomes in cervical cancer patients treated with CRT, whereas elevated pCDK9 levels predict worse survival in this patient population." 02/01/2005 - "Based on our previous generation of reconstructed human caspase-8, which can continuously induce apoptosis of cervical cancer cell line HeLa, by reversing its large and small subunits, this study was designed to investigate the pro-apoptotic efficiencies of 3 reconstructed human caspase-8 (Casp8CD, Rev8, and Rev8L) on HeLa cells, and to explore the feasibility of reconstructed human caspase-8 as potential apoptosis-inducing candidates. " 11/18/2022 - "Crucially, low Caspase-8 expression in cervical cancer patients leads to poor prognosis, higher CDK9 phosphorylation at Thr186, and increased RNAPII activity in cervical cancer cell lines and patient biopsies. " 02/01/2012 - "Treatment with caspase-8 and -3 inhibitors also recovered cell cycling, and Fas/FasL expression increased in N101-2-treated cervical cancer cells, suggesting that Fas-mediated extrinsic apoptosis signaling was also activated. " 05/01/2005 - "Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid."
5.	Reperfusion Injury 02/01/2023 - "Ischemia/reperfusion injury also significantly upregulated caspase-1, caspase-8, and NLRP3 expression, which are important components of the PANoptosome. " 07/01/2019 - "Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8." 06/01/2019 - "Loss of receptor interacting protein kinases 3 and caspase-8 augments intrinsic apoptosis in tubular epithelial cell and promote kidney ischaemia-reperfusion injury." 01/01/2017 - "We have previously shown that while silencing caspase-8 in an in vivo ischemia reperfusion injury (IRI) model results in improved organ function and survival, removal of caspase-8 function in a donor organ can paradoxically result in enhanced receptor-interacting protein kinase 1/3- (RIPK1/3-) regulated necroptosis and accelerated graft loss following transplantation. " 08/01/2004 - "Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice."

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Proteins (Proteins, Gene)
3.	Caspase 9
4.	Messenger RNA (mRNA)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Inflammasomes
7.	Caspases
8.	Cytochromes c (Cytochrome c)
9.	Interleukin-6 (Interleukin 6)
10.	Caspase 8 (Caspase-8)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation
3.	Therapeutics
4.	Chemoradiotherapy
5.	Cardiopulmonary Resuscitation (CPR)