Caspase 8 (Caspase-8)

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Also Known As:

Networked: 1477 relevant articles (24 outcomes, 125 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Trautwein, Christian: 10 articles (01/2014 - 06/2003)
2.	Hao, Chunhai: 10 articles (02/2012 - 07/2002)
3.	Liedtke, Christian: 9 articles (03/2015 - 06/2003)
4.	Lahti, Jill M: 9 articles (07/2013 - 03/2002)
5.	Stupack, Dwayne G: 8 articles (05/2013 - 01/2006)
6.	Longley, Daniel B: 7 articles (12/2014 - 06/2007)
7.	Green, Douglas R: 7 articles (11/2014 - 10/2002)
8.	Wallach, David: 7 articles (01/2013 - 04/2006)
9.	Park, Won Sang: 7 articles (02/2005 - 04/2002)
10.	Yoo, Nam Jin: 7 articles (02/2005 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2008 - "Cotreatment of mice with DATS and TRAIL was more effective in inhibiting prostate tumor growth and inducing DR4 and DR5 expression, caspase-8 activity, and apoptosis than either agent alone. " 10/01/2014 - "In this study, we examined the impact of four, representative, HNSCC-associated procaspase-8 mutations on activation of the extrinsic apoptosis pathway, as well as cellular migration and invasion, and in vivo tumor growth. " 04/12/2012 - "In the present study, we report that the loss of caspase-8 in B lymphocytes leads to B-cell malignancies and that the risk for these tumors is further enhanced in the absence of p53. " 12/01/2010 - "Previous studies have suggested that the caspase 8 inhibitor FLIP is a promising anti-cancer therapeutic target. " 05/01/2010 - "Several potentially functional polymorphisms of CASP8 encoding an apoptotic enzyme, caspase 8, have been implicated in cancer risk, but individually published studies showed inconclusive results. "
2.	Ischemia 01/29/2008 - "Our findings suggest a possible association between expression of FADD, caspase-8, Daxx and FAP-1 genes and apoptosis following ischemia." 11/01/2004 - "Regarding cell death by apoptosis, although ischemia did increase caspase-8-like activity, there were no changes in caspase-3-like activity, which is activated downstream of caspase-8; this may indicate that the apoptotic cascade is not activated by 60 minutes of ischemia. " 04/01/2001 - "After transient focal ischemia in mice, Par-4 levels were increased 6 to 12 hours after reperfusion in the infarcted cortex and the striatum, and activation of caspase-8 occurred with a similar time course. " 07/01/2008 - "Mild hypothermia significantly reduced expression of Fas and processed caspase-8 both by approximately 50%, but prevented ischemia-induced FasL decreases. " 01/01/2005 - "The protein levels of proapoptotic caspase-8 and antiapoptotic bcl-2 were increased after global ischemia-hypotension and HBO potentiated the expression of caspase-8 and decreased expression of bcl-2. "
3.	Neuroblastoma 07/01/2009 - "The present study utilized oligoarrays to evaluate the methylation status of a CpG island located between exons 2 and 3 of caspase 8 in neuroblastomas. " 06/15/2001 - "Our in vitro studies showed that FLIP was recruited to the death-inducing signaling complex and interfered with the recruitment of caspase 8 in neuroblastoma cells. " 07/01/2013 - "This model recapitulates 2 frequent alterations in metastatic neuroblastoma, overexpression of MYCN and loss of caspase-8 expression. " 06/01/2012 - "In neuroblastoma caspase-8 is frequently silenced by DNA methylation. " 06/01/2012 - "FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma."
4.	Inflammation 01/01/2015 - "Studies on multiple double- and triple- knockout mice identified caspase-8, flip, and fadd genes as key regulators of embryonic lethality and inflammation. " 07/31/2015 - "Caspase-8 is a key mediator in various biological processes such as apoptosis, necroptosis, inflammation, T/B cells activation, and cell motility. " 05/01/2015 - "Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways." 01/01/2015 - "Here, we address recent findings on caspase-8 and its role in modulating IL-1β and inflammation. " 11/01/2014 - "According to this model, both excessive activity as well as a lack of activity of caspase-8 results in epithelial cell death and intestinal inflammation and caspase-8 needs to be tightly controlled to warrant tissue homeostasis in the gut. "
5.	Glioma (Gliomas) 09/01/2009 - "Our study now clearly indicates that LRIG1 indeed affects cell fate and biology behaviors of the cells in vitro by inhibiting phosphorylation of downstream MAPK and AKT signaling pathway, and the elevated release level of caspase-8 might contribute to the enhanced apoptosis in LRIG1 transfected glioma cells. " 05/01/2000 - "In this study, we transduced the Bax gene in combination with caspase-8 gene to evaluate whether or not this approach induces effective cytotoxicity in glioma cells. " 01/01/2014 - "Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells." 09/01/2013 - "miR-107 expression induced apoptosis in glioma cells possibly through the increase in Fas (TNFRSF6)-associated via death domain (FADD) expression and activation of caspases-8 and -3/7. Moreover, the activity of caspase-8 in miR-107-overexpressing SHG44 cells was suppressed with FADD knockdown. " 05/01/2010 - "We also show that these stem cells derived from the human umbilical cord blood (hUCB) induce apoptosis-like cell death in the glioma cell line SNB19 via Fas-mediated caspase-8 activation. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Caspase 9
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Cytochromes c (Cytochrome c)
7.	Apoptosis Regulatory Proteins
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Caspase 6
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Injections
5.	Lasers (Laser)