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Caspase 7

A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

Also Known As:

Apoptotic Protease Mch-3; Caspase-7; ICE-Like Apoptotic Protease 3; Mch-3 Protease; Pro-caspase 7; Pro-caspase-7; Procaspase 7; Procaspase-7; Apoptotic Protease Mch 3; ICE Like Apoptotic Protease 3; Mch 3 Protease; Mch-3, Apoptotic Protease; Pro caspase 7; Protease Mch-3, Apoptotic; Protease, Mch-3

Networked: 158 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Luo, Ting: 4 articles (09/2013 - 03/2009)
2.	Jiang, Yangfu: 4 articles (09/2013 - 03/2009)
3.	Bode, Ann M: 3 articles (11/2015 - 06/2011)
4.	Dong, Zigang: 3 articles (11/2015 - 06/2011)
5.	Kajo, Karol: 3 articles (04/2015 - 10/2014)
6.	Výbohová, Desanka: 3 articles (04/2015 - 10/2014)
7.	Kubatka, Peter: 3 articles (04/2015 - 10/2014)
8.	Péč, Martin: 3 articles (04/2015 - 10/2014)
9.	Kassayová, Monika: 3 articles (04/2015 - 10/2014)
10.	Stollárová, Nadežda: 3 articles (04/2015 - 10/2014)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "In the present study, we demonstrate that γ-T3 induces apoptosis in MDA-MB 231 and MCF-7 breast cancer cells as evident by PARP cleavage and caspase-7 activation. " 01/01/2015 - "Targeting survivin by YM155 modulated autophagy, induced autophagy-dependent caspase-7 activation and autophagy-dependent DNA damage in breast cancer cells. " 01/01/2013 - "The EEC treated MCF-7 cells also showed an increase in Bax/Bcl-2 ratio that in turn activated the caspase-dependent pathways by activating caspase 7. Thus, marine microalga, Chaetoceros calcitrans may be considered a good candidate to be developed as a new anti-breast cancer drug." 12/01/2009 - "Additional investigation showed that the mitochondrial damage was induced by the generation of ROS and the subsequent activation of caspase-7 and -9. Our findings demonstrate that VK(3)-induced apoptosis is selectively initiated by the mitochondria-related pathway and might be useful in breast cancer chemotherapy." 09/01/2013 - "HSP27 knockdown leads to an increase in Act D-induced caspase 3 and caspase 7 cleavage, and sensitizes rhabdosarcoma cells and breast cancer cells to Act D-induced apoptosis. "
2.	Autistic Disorder (Autism) 01/01/2012 - "Alteration of the selected parameters confirm the role of neuroinflammation and apoptosis mechanisms in the etiology of autism together with the possibility of the use of HSP70, TGF-β2, Caspase 7 and INF-γ as predictive biomarkers that could be used to predict safety, efficacy of a specific suggested therapy or natural supplements, thereby providing guidance in selecting it for patients or tailoring its dose." 01/01/2012 - "This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β2, Caspase 7 and interferon-γ (IFN-γ)in the pathophysiology of autism. "
3.	Neoplasms (Cancer) 11/01/2015 - "Caspase-7 is reportedly expressed at reduced levels in many cancers. " 08/27/2015 - "Potency of 22 was superior to 1 in MCF7 tumor spheroids and the mechanism of cell death was shown to be via apoptosis with an increase in cleaved PARP and activated caspase-7. " 01/01/2015 - "Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. " 09/01/2013 - "Unshackling caspase-7 for cancer therapy." 01/01/2013 - "Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. "
4.	Retinal Degeneration 01/01/2013 - "Therefore, the goal of this study is to validate the UPR-induced caspase-7 as a new therapeutic target that modulates the UPR, reduces the level of apoptosis and protects the ADRP retina from retinal degeneration and light-induced damage. " 01/01/2014 - "The goal of this study is to validate whether reprogramming of the UPR via modulation of pro-apoptotic caspase-7 and CHOP proteins could be an effective approach to slow down the rate of retinal degeneration in ADRP mice. " 01/01/2013 - "Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration."
5.	Rheumatoid Arthritis 10/01/2008 - "To study the possible role of the caspase 7 (CASP7) gene in susceptibility to rheumatoid arthritis (RA) in a European Caucasian population. " 08/01/2007 - "The aim of this study was to investigate the possible role of the caspase 7 (CASP7) in susceptibility to rheumatoid arthritis (RA). " 08/01/2007 - "Caspase 7 influences susceptibility to rheumatoid arthritis."

Related Drugs and Biologics

1.	Biological Markers (Surrogate Marker)
2.	p38 Mitogen-Activated Protein Kinases
3.	sulforafan (sulforaphane)
4.	Caspase 3 (Caspase-3)
5.	Caspase 9
6.	Proteins (Proteins, Gene)
7.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
8.	Interleukin-8 (Interleukin 8)
9.	Effector Caspases
10.	9,10-Dimethyl-1,2-benzanthracene (DMBA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Photochemotherapy (Photodynamic Therapy)