Hypoalphalipoproteinemias (Hypoalphalipoproteinemia)

Conditions with abnormally low levels of ALPHA-LIPOPROTEINS (high-density lipoproteins) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding APOLIPOPROTEIN A-I; LECITHIN CHOLESTEROL ACYLTRANSFERASE; and ATP-BINDING CASSETTE TRANSPORTERS.
Also Known As:
Hypoalphalipoproteinemia; Familial High Density Lipoprotein Deficiency Disease; Familial High-Density Lipoprotein Deficiency Disease; Familial alpha-Lipoprotein Deficiency Disease; HDL Cholesterol, Low Serum; HDL Lipoprotein Deficiency Disease; High-Density Lipoprotein Deficiency Disease, Familial; Hypo alpha Lipoproteinemia; Hypoalphalipoproteinemia, Primary; Familial Hypoalphalipoproteinemia; Familial Hypoalphalipoproteinemias; Familial alpha Lipoprotein Deficiency Disease; High Density Lipoprotein Deficiency Disease, Familial; Hypo alpha Lipoproteinemias; Hypoalphalipoproteinemias, Familial; Hypoalphalipoproteinemias, Primary; Lipoproteinemia, Hypo alpha; Lipoproteinemias, Hypo alpha; Primary Hypoalphalipoproteinemias; alpha Lipoprotein Deficiency Disease, Familial; alpha Lipoproteinemia, Hypo; Hypoalphalipoproteinemia, Familial; Lipoprotein Deficiency Disease, HDL, Familial; alpha-Lipoprotein Deficiency Disease, Familial
Networked: 207 relevant articles (7 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypertriglyceridemia
2. Hyperlipidemias (Hyperlipidemia)
3. Hypertension (High Blood Pressure)
4. Coronary Artery Disease (Coronary Atherosclerosis)
5. Hyperinsulinism (Hyperinsulinemia)


1. Calabresi, Laura: 8 articles (11/2013 - 02/2002)
2. Kastelein, John J P: 7 articles (12/2014 - 10/2002)
3. Franceschini, Guido: 7 articles (11/2013 - 02/2002)
4. Hovingh, G Kees: 6 articles (03/2015 - 06/2003)
5. Hayden, Michael R: 5 articles (08/2006 - 10/2002)
6. Hegele, Robert A: 4 articles (01/2019 - 07/2002)
7. Stroes, Erik S G: 4 articles (12/2014 - 06/2003)
8. Simonelli, Sara: 4 articles (11/2013 - 06/2011)
9. Bisoendial, Radjesh J: 4 articles (12/2009 - 06/2003)
10. Pisciotta, Livia: 3 articles (10/2021 - 09/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoalphalipoproteinemias:
1. HDL CholesterolIBA
2. Lipoproteins (Lipoprotein)IBA
3. Triglycerides (Triacylglycerol)IBA
4. HDL LipoproteinsIBA
5. Gemfibrozil (Lopid)FDA LinkGeneric
6. LDL CholesterolIBA
01/01/2018 - "Fifty percent of the patients had obesity and overweight, 59% had hypertriglyceridemia, 40%, hypoalphalipoproteinemia, 27.5%, high LDL-cholesterol and 22.5% insulin resistance. "
02/01/2012 - "We resequenced ANGPTL3 in 4 members of 3 kindreds originally identified for very low levels of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (0.97±0.16 and 0.56±0.20 mmol/L, respectively) in whom no mutations of known candidate genes for monogenic hypobetalipoproteinemia and hypoalphalipoproteinemia had been detected. "
04/01/1995 - "To determine whether high CETP activities are associated with isolated hypoalphalipoproteinemia, CETP activities were measured in 109 adult men with HDL cholesterol < 35 mg/dL, plasma triglycerides < 200 mg/dL, and LDL cholesterol < 160 mg/dL; the results were compared with those of 50 normolipidemic (HDL cholesterol > 40 mg/dL) male subjects. "
11/16/1983 - "The criteria for the definition of familial hypo-alpha-lipoproteinemia are, therefore, as follows: 1) low HDL-cholesterol level in the presence of normal VLDL and LDL-cholesterol levels; 2) absence of diseases or factors to which hypo-alpha-lipoproteinemia might be secondary; 3) presence of a similar lipoprotein pattern in a first degree relative."
01/01/1994 - "Although there is consensus that lipid variables, especially lipoprotein(a), are heritable and that elevated LDL cholesterol levels should be treated, there are no clear definitions of the common familial lipid disorders associated with premature CHD (lipoprotein(a) excess, FCH, familial dyslipidemia, familial hypoalphalipoproteinemia, familial hypercholesterolemia), nor do we have clear guidelines for the treatment of most of these disorders. "
7. Lovastatin (Mevacor)FDA LinkGeneric
8. avasimibeIBA
9. ChylomicronsIBA
10. Catechin (Z 7300)IBA

Therapies and Procedures

1. Therapeutics
2. Art Therapy
3. Kidney Transplantation
4. Drug Therapy (Chemotherapy)
5. Secondary Prevention