BB Form Creatine Kinase

01/01/1985 - "Creatine kinase BB in blood as index of prognosis and effect of treatment after severe head injury."
01/01/1982 - "The diagnostic value of measuring creatine kinase BB activity in cerebrospinal fluid following acute head injury."
09/20/1980 - "Radioimmunoassay of serum creatine kinase BB as index of brain damage after head injury."
01/01/1989 - "Creatine-kinase-BB after severe head-injury as an index of prognosis in relation to nature of trauma and patients age."
11/01/1986 - "CSF brain creatine kinase levels and lactic acidosis in severe head injury."

07/01/1992 - "Elevated serum levels of creatine kinase BB in autosomal dominant osteopetrosis type II--a family study."
08/01/2000 - "Creatine kinase-BB in mammalian osteopetrosis is related to osteoclastic number and size, where it probably reflects the differentiation and maturation of inactive bone resorbing cells. "
08/01/2000 - "Although creatine kinase-BB was unchanged in Type 1 autosomal dominant osteopetrosis at baseline and after stimulation, the rodent counterparts characterized by small osteoclasts, microphthalmic and osteopetrotic mice and toothless rats, had significantly decreased levels. "
08/01/2000 - "Creatine kinase-BB was increased markedly in Type 2 autosomal dominant osteopetrosis and in the incisors absent rat, both characterized by large numbers of giant osteoclasts, and did not change significantly after stimulation. "
08/01/2000 - "Recently, high blood levels of creatine kinase-BB have been reported in some human forms, suggesting it as a marker of osteopetrosis. "

04/05/2005 - "Our previous studies established in U87-MG glioblastoma cells that elevated cAMP increased transcription of the endogenous as well as a transiently-transfected brain creatine kinase (CKB) gene, despite the absence of a cAMP response element (CRE) in the CKB proximal promoter. "
04/05/2005 - "Transcription of brain creatine kinase in U87-MG glioblastoma is modulated by factor AP2."
05/15/1999 - "Proximal promoter of the rat brain creatine kinase gene lacks a consensus CRE element but is essential for the cAMP-mediated increased transcription in glioblastoma cells."
12/01/1995 - "Prostaglandin E1, E2, and cholera toxin increase transcription of the brain creatine kinase gene in human U87 glioblastoma cells."
05/15/1999 - "Our previous studies have shown that transcription of brain creatine kinase (CKB) mRNA in U87-MG glioblastoma cells is stimulated by a forskolin-mediated increase in cyclic AMP (cAMP) via a pathway involving protein kinase A (PKA) and the activation of Galphas proteins. "

12/31/1989 - "Creatine kinase-BB activity in malignant tumors and in sera from patients with malignant diseases."
09/16/1985 - "Comparison of enzymatic characteristics of creatine kinase BB from human healthy and tumor stomach tissues."
08/01/1979 - "Creatine kinase BB: a new tumor-associated marker."
03/01/1984 - "In endometrial cancer creatine kinase BB activity was higher in well differentiated than in poorly differentiated tumors."
06/01/1995 - "To develop a highly sensitive immunofluorometric procedure for creatine kinase BB isoenzyme and use it to measure CK-BB in tumor cytosolic extracts and serum of cancer patients and healthy volunteers. "

01/01/2006 - "Cytosolic brain-type creatine kinase (BB-CK), which is coexpressed with ubiquitous mitochondrial uMtCK, is significantly inactivated by oxidation, in Alzheimer's disease (AD) patients. "
06/01/2000 - "Oxidative modification of creatine kinase BB in Alzheimer's disease brain."
03/01/1998 - "The report shows that Alzheimer's disease (AD) brain creatine kinase (CK) is modified such that the nucleotide binding site of CK is blocked and that abnormal partitioning of CK between the soluble and pellet fractions occurs. "
08/01/1987 - "Serum creatine kinase-BB levels and cerebral cortical creatine kinase activity in senile dementia of the Alzheimer type."
01/01/1989 - "[BB creatine kinase isoenzyme activity in the blood serum of patients with senile dementia, Alzheimer's disease and schizophrenia]."