Endocrine Disruptors

Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.

Also Known As:

Networked: 1503 relevant articles (5 outcomes, 198 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Choi, Kyung-Chul: 16 articles (09/2022 - 06/2011)
2.	Calafat, Antonia M: 15 articles (01/2021 - 06/2012)
3.	Sargis, Robert M: 13 articles (10/2020 - 07/2010)
4.	Hauser, Russ: 12 articles (08/2022 - 06/2009)
5.	Hwang, Kyung-A: 12 articles (09/2018 - 06/2011)
6.	Kannan, Kurunthachalam: 10 articles (01/2022 - 02/2014)
7.	Blumberg, Bruce: 10 articles (12/2021 - 03/2011)
8.	Baskin, Laurence S: 10 articles (05/2015 - 03/2006)
9.	Heindel, Jerrold J: 8 articles (01/2017 - 12/2003)
10.	Prins, Gail S: 8 articles (01/2016 - 06/2006)

Related Diseases

1.	Neoplasms (Cancer) 03/23/2023 - "Although numerous studies support a dose-effect relationship between Endocrine disruptors (EDs) and the progression and malignancy of tumors, the impact of a chronic exposure to non-lethal concentrations of EDs in cancer remains unknown. " 12/01/2022 - "With regard to toxicological aspects, several studies suggest that phthalates would act as endocrine-disrupting chemicals, and they have been correlated to several forms of cancer. " 04/23/2022 - "This review explores the evidence linking parental exposure to pesticides and endocrine disruptors to intergenerational and transgenerational susceptibility of cancer in population studies and animal models. " 01/01/2020 - "Although some studies reported no relation between environmental NP exposure and tumour and/or cancer progression, NP (a known endocrine disrupting chemical) induced action mechanisms in multiple experimental models and may interfere with/hyper-activate oestrogen signalling. " 06/01/2016 - "We know little about how many cancers can be associated with endocrine disruptors, as there are too few reliable exposure studies to support an association. "
2.	Cardiovascular Diseases (Cardiovascular Disease) 05/01/2015 - "Recent studies have associated endocrine-disrupting chemical (EDC) exposure with the increased risk of cardiovascular disease in humans, but the underlying mechanisms responsible for these associations remain elusive. " 01/01/2022 - "Fetal exposure to endocrine-disrupting chemicals such as phthalates and bisphenols might lead to fetal cardiovascular developmental adaptations and predispose individuals to cardiovascular disease in later life. " 12/28/2021 - "Environmental Contaminants Acting as Endocrine Disruptors Modulate Atherogenic Processes: New Risk Factors for Cardiovascular Diseases in Women?" 01/01/2020 - "The association between environmental endocrine disruptors and cardiovascular diseases: A systematic review and meta-analysis." 11/01/2022 - "Pregnant women are simultaneously exposed to several non-persistent endocrine-disrupting chemicals, which may influence the risk of childhood obesity and cardiovascular diseases later in life. "
3.	Prostatic Neoplasms (Prostate Cancer) 09/01/2009 - "Herein, the possible effect of BPA on prostate cancer treatment and disease management for humans is explored as an example of environmental endocrine disruptor exposure reducing the efficacy of disease management. " 01/01/2020 - "Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer (PCa). " 02/06/2023 - "Endocrine Disrupting Chemicals Influence Hub Genes Associated with Aggressive Prostate Cancer." 01/21/2022 - "Endocrine Disruptors and Prostate Cancer." 01/01/2022 - "We successfully evaluated the relationship between prostate cancer and alternative bisphenols; as a result, a novel approach was proposed to explore the damaging effect of environmental endocrine disruptors."
4.	Wounds and Injuries (Trauma) 04/01/2018 - "In humans, pioneer studies showed that exposure to famine, endocrine disruptors or trauma can affect descendants, and has led to a paradigm shift in thinking about heredity. " 01/01/2022 - "In rodent models, stress/trauma, poor diet, and endocrine disruptors in a parent have been shown to cause phenotypes in the direct progeny, suggesting intergenerational inheritance. " 01/01/2017 - "Due to this maturational delay, developing males also are more vulnerable over a longer period of time to stressors in the social environment (attachment trauma) and toxins in the physical environment (endocrine disruptors) that negatively impact right-brain development. " 10/01/2016 - "Our study revealed that nanomolar bisphenol A (BPA), one of the most ubiquitous endocrine disruptors, can increase wound closure and invasion of both MDA-MB-231 and BT-549 cells. " 01/01/2014 - "However, coadministration of GEN could partially alleviate DEHP-induced reproductive injuries via enhancement of testicular antioxidative enzymes activities, which indicates that GEN has protective effects on DEHP-induced male reproductive system damage after prepubertal exposure and GEN may have promising future in its curative antioxidative role for reproductive disorders caused by other environmental endocrine disruptors. "
5.	Human Influenza (Influenza) 10/01/2020 - "Taken together, our results demonstrate for the first time the use of a calixarene-based detergent as an efficient splitting agent for the production of optimized influenza split antigens, paving the way for significant improvement in the vaccine manufacturing process, notably with regard to the current regulation on the prohibition of endocrine disruptors, such as Triton X-100."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Diethylhexyl Phthalate (DEHP)
3.	Androgens
4.	Enzymes
5.	Calixarenes (Calixarene)
6.	Progesterone Congeners
7.	Octoxynol (Triton X 100)
8.	Vaccines
9.	Detergents (Detergent)
10.	Antigens

Related Therapies and Procedures

1.	Therapeutics
2.	Subcutaneous Injections
3.	Drug Therapy (Chemotherapy)
4.	Bariatric Surgery
5.	Skin Care