Endocrine Disruptors

Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.

Also Known As:

Networked: 377 relevant articles (2 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Choi, Kyung-Chul: 9 articles (10/2015 - 06/2011)
2.	Soto, Ana M: 8 articles (09/2015 - 05/2002)
3.	Baskin, Laurence S: 8 articles (05/2015 - 03/2006)
4.	Heindel, Jerrold J: 7 articles (11/2015 - 12/2003)
5.	Hwang, Kyung-A: 7 articles (10/2015 - 06/2011)
6.	Sargis, Robert M: 7 articles (09/2015 - 07/2010)
7.	Sonnenschein, Carlos: 6 articles (09/2015 - 05/2002)
8.	Vrijheid, Martine: 5 articles (10/2015 - 07/2002)
9.	Prins, Gail S: 5 articles (10/2015 - 06/2006)
10.	Newbold, Retha R: 5 articles (12/2011 - 04/2007)

Related Diseases

1.	Cardiovascular Diseases (Cardiovascular Disease) 02/01/2011 - "Considering the recent studies that question previously reported cardio-protective effects of estrogen, there is a growing concern that endocrine disruptors may also contribute to the pathology of cardiovascular disease. "
2.	Wounds and Injuries (Trauma) 01/01/2014 - "However, coadministration of GEN could partially alleviate DEHP-induced reproductive injuries via enhancement of testicular antioxidative enzymes activities, which indicates that GEN has protective effects on DEHP-induced male reproductive system damage after prepubertal exposure and GEN may have promising future in its curative antioxidative role for reproductive disorders caused by other environmental endocrine disruptors. "
3.	Obesity 04/01/2015 - "There is irrefutable evidence from human and animal studies that nutrient and environmental agent exposures (for example, endocrine disruptors) during pregnancy may affect fetal/newborn development resulting in offspring obesity and obesity-associated metabolic abnormalities (metabolic syndrome). " 02/01/2015 - "A few earlier studies have associated exposure to endocrine-disrupting chemicals (EDCs) with childhood obesity. " 09/01/2013 - "Recent studies suggest that endocrine disrupting chemicals (EDCs) may form a risk factor for obesity by altering energy metabolism through epigenetic gene regulation. " 08/15/2012 - "Epidemiology studies indicate that exposure to endocrine disruptors during developmental "window" contributes to adipogenesis and the development of obesity. " 08/01/2011 - "The study findings suggest that some endocrine disruptors may play a role for the development of the obesity epidemic, in addition to the more commonly perceived putative contributors."
4.	Hypospadias 12/01/2015 - "Numerous studies have focused on the association between endocrine-disrupting chemicals (EDCs) and hypospadias. " 01/01/2011 - "The study provides some but limited evidence that occupational exposure to possible endocrine disrupting chemicals during pregnancy increases the risk of hypospadias." 08/01/2004 - "Recent studies have implicated factors such as familial inheritance, low birth weight, assisted reproductive technology, advanced maternal age, paternal subfertility, and endocrine-disrupting chemicals in the pathogenesis of hypospadias. " 07/01/2002 - "A study to assess the association between the prevalence of hypospadias and maternal occupational exposure to potential endocrine-disrupting chemicals was carried out using data from the congenital anomaly register of the Office for National Statistics. " 07/01/2002 - "A job-exposure matrix for potential endocrine-disrupting chemicals developed for a study into the association between maternal occupational exposure and hypospadias."
5.	Neoplasms (Cancer) 07/01/2015 - "In conclusion, the carcinogenic effects of endocrine disruptors on female cancer types is plausible although additional studies are needed to clarify their mechanisms and entities. " 10/01/1999 - "The purpose of this study was to find out some clues for generating a working hypothesis that the contamination of drinking water with environmental chemicals especially of endocrine disrupting chemicals in big rivers may be related to the occurrence of cancers. " 10/01/2015 - "It is long recognized that environmental factors play a major role in cancer etiology, and emerging data suggest that endocrine-disrupting chemicals (EDCs) may contribute to an increased cancer risk. " 07/01/2015 - "Pollutants altering the endocrine system, known as endocrine disruptors (ED), may modify the risk of female cancers. " 07/01/2015 - "Endocrine disruptors and female cancer: Informing the patients (Review)."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Diethylhexyl Phthalate (DEHP)
3.	Enzymes
4.	bisphenol A
5.	Biological Markers (Surrogate Marker)
6.	Vitellogenins (Vitellogenin)
7.	Carcinogens
8.	Genistein
9.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
10.	Estrogen Receptors

Related Therapies and Procedures

1.	Skin Care
2.	Heterologous Transplantation (Xenotransplantation)
3.	Radiotherapy
4.	Subcutaneous Injections
5.	Drug Therapy (Chemotherapy)