Resistin

A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake.

Also Known As:

Networked: 2883 relevant articles (87 outcomes, 695 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Osawa, Haruhiko: 24 articles (03/2020 - 03/2002)
2.	Lazar, Mitchell A: 21 articles (11/2017 - 01/2002)
3.	Makino, Hideichi: 19 articles (10/2010 - 03/2002)
4.	Tang, Chih-Hsin: 18 articles (08/2021 - 01/2015)
5.	Onuma, Hiroshi: 17 articles (01/2018 - 03/2002)
6.	Derosa, Giuseppe: 16 articles (01/2021 - 05/2008)
7.	Maffioli, Pamela: 16 articles (01/2021 - 05/2008)
8.	D'Angelo, Angela: 15 articles (01/2021 - 05/2008)
9.	Johns, Roger A: 14 articles (01/2021 - 12/2006)
10.	Ahima, Rexford S: 14 articles (04/2019 - 02/2004)

Related Diseases

1.	Insulin Resistance 01/01/2018 - "Therefore, the gene expression of resistin, a direct transcriptional target of FOXO1, is reduced and insulin sensitivity is improved. " 07/01/2004 - "Immunoneutralization of resistin improved insulin sensitivity in diet-induced obese mice, while the administration of exogenous resistin induced insulin resistance. " 06/01/2004 - "The decrease in plasma resistin is positively correlated with the decrease in hepatic fat content and improvement in hepatic insulin sensitivity." 01/01/2021 - "This is the first study which, reports that resistin mitigates the stemness of hADSC by reducing proliferation, inducing insulin resistance, and hampering maturation of adipocyte and osteocyte which could lead to metabolic disorders." 08/01/2019 - "[9] In this study, we aimed to investigate the in vitro effects of resistin on the expression of various genes related to insulin resistance in mouse liver cells. "
2.	Obesity 05/01/2023 - "Resistin G-A haplotype at SNP-420/-358 is associated with the latent sarcopenic obesity index in the toon genome study." 09/20/2022 - "Thus, this study aimed to determine the functional activity of macrophages present in the breast milk and colostrum of diabetic mothers with obesity and the effects of resistin on these cells. " 07/31/2022 - "Therefore, the study assessed plasma resistin and explored its relationship with obesity and selected cardiometabolic risks. " 03/07/2019 - "Objective: this study was designed to determine the relationship of body components (VAT and SMM) with MS and resistin in patients with obesity. " 02/01/2018 - "This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in RETN gene 420C/G; 44G/A; 62G/A; 394C/G and 299 G/A and their association with Resistin level and obesity in Tunisian volunteers. "
3.	Inflammation (Inflammations) 12/30/2021 - "The aim of this study was to investigate the usefulness of resistin and its relationship with ID and selected indicators of inflammation in horses. " 02/23/2014 - "Our animal study verified that the distribution of resistin in the liver is correlated with inflammation in NASH. " 03/01/2011 - "This is the first study to demonstrate elevated levels of resistin and sFas in HPV persistently infected, older women with decreased immune function expanding the understanding of the systemic inflammation and immune alterations in individuals persistently infected with HPV. " 05/01/2007 - "The aim of the present study was to assesses the serum resistin concentrations in AP patients and evaluate the correlation between resistin and the well known inflammation marker--CRP. " 12/01/2006 - "The aim of this study was to correlate resistin with markers of inflammation and endothelial cell injury in 96 kidney allograft recipients. "
4.	Weight Loss (Weight Reduction) 01/01/2022 - "Role of the rs10401670 variant in the resistin gene on the metabolic response after weight loss secondary to a high-fat hypocaloric diet with a Mediterranean pattern." 09/14/2017 - "There were no significant differences in resistin levels between morbidly obese patients and healthy subjects of normal weight, or between obese patients before and after weight loss. " 04/01/2011 - "In 33 children without substantial weight loss, resistin and MCP-1 levels increased after 1 year. " 11/01/2008 - "Creating two groups defined by NPY and resistin genotype, respectively, with similar BMI values resulted in significant differences concerning weight loss and metabolic improvement. " 09/01/2008 - "Only serum resistin levels were associated with weight loss. "
5.	Body Weight (Weight, Body) 09/13/2023 - "Multivariate logistic regression analysis highlighted resistin, diabetes, and body weight as independent predictors of aortic stiffness. " 02/01/2021 - "We found that serum resistin is not a useful marker for predicting the severity of AP and does not correlate with increasing body weight." 04/16/2020 - "In the logistic regression analysis the T-allele of the SNP rs10401670, adjusted by age, sex, resistin levels, and body weight showed an association with DM2 - OR: 2.27 (95% CI: 1.26-4.09). " 07/01/2016 - "A highly significant negative correlation was found between serum resistin levels and the two contributing factors of total body weight and body mass index (BMI) as well as demonstrating a significant negative correlation between serum resistin levels and height percentiles." 09/01/2014 - "Women carrying the T allele of TCF7L2 rs4506565 had increases in plasma resistin of 9.38 μg/L (95% CI 1.39-17.37; p=0.022) per allele; this association remained significant after adjusting for pre-gestational body weight. "

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7.	Triglycerides (Triacylglycerol)
8.	Interleukin-6 (Interleukin 6)
9.	Cytokines
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5.	Intravenous Injections