Fanconi Anemia Complementation Group A Protein

A Fanconi anemia complementation group protein that is the most commonly mutated protein in FANCONI ANEMIA. It undergoes PHOSPHORYLATION by PROTEIN KINASE B and forms a complex with FANCC PROTEIN in the CELL NUCLEUS.

Also Known As:

FANCA Protein; Fanconi Anemia Group A Complementing Protein; Fanconi Anemia Group A Protein

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Liu, Johnson M: 2 articles (03/2008 - 03/2002)
2.	Chen, Fei: 2 articles (11/2007 - 10/2005)
3.	Joenje, H: 2 articles (06/2000 - 04/2000)
4.	Hwang, Soo Kyung: 1 article (09/2013)
5.	Kim, Sung Hak: 1 article (09/2013)
6.	Kim, Sunshin: 1 article (09/2013)
7.	Kwak, Heejin: 1 article (09/2013)
8.	Lee, Chang-Hun: 1 article (09/2013)
9.	Lee, Mihee: 1 article (09/2013)
10.	Son, Kook: 1 article (09/2013)

Related Diseases

1.	Fanconi Anemia (Fanconi's Anemia) 11/01/2007 - "To study FANCA protein expression in Fanconi anemia patient's (FA) cells and explore its function. " 10/01/2005 - "To screen the FANCA gene mutation and explore the FANCA protein function in Fanconi anemia (FA) patients. " 03/01/2002 - "Phosphorylation of the Fanconi anemia complementation group A (FANCA) protein is thought to be important for the function of the FA pathway. " 06/01/2000 - "Fanconi anemia A due to a novel frameshift mutation in hotspot motifs: lack of FANCA protein." 04/01/2000 - "Cloning and characterization of murine fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary."
2.	Genomic Instability 10/01/2005 - "These data identify the Fanca protein as an integral component in the early step of HDR of DSBs and thereby minimizing the genomic instability."
3.	Ataxia Telangiectasia (Louis Bar Syndrome) 03/01/2008 - "In primary fibroblasts with mutations in the core complex FANCA protein, we discovered that basal expression and phosphorylation of ATM (ataxia telangiectasia mutated) and p53 induced by irradiation (IR) or mitomycin C (MMC) were upregulated. "

Related Drugs and Biologics

1.	Mitomycin (Mitomycin-C)
2.	Proteins (Proteins, Gene)
3.	Nucleic Acids