N-Ethylmaleimide-Sensitive Proteins (N-Ethylmaleimide-Sensitive Fusion Protein)

ATPases that are members of the AAA protein superfamily (ATPase family Associated with Diverse cellular Activities). The NSFs functions, acting in conjunction with SOLUBLE NSF ATTACHMENT PROTEINS (i.e. SNAPs, which have no relation to SNAP 25), are to dissociate SNARE complexes.

Also Known As:

N-Ethylmaleimide-Sensitive Fusion Protein; N-Ethylmaleimide-Sensitive ATPase; N-Ethylmaleimide-Sensitive Factor; N-Ethylmaleimide-Sensitive Factors; N-Ethylmaleimide-Sensitive Protein; NEM-Sensitive Fusion Proteins; NSF ATPase; ATPase, N-Ethylmaleimide-Sensitive; ATPase, NSF; N Ethylmaleimide Sensitive ATPase; N Ethylmaleimide Sensitive Factor; N Ethylmaleimide Sensitive Factors; N Ethylmaleimide Sensitive Fusion Protein; N Ethylmaleimide Sensitive Protein; N Ethylmaleimide Sensitive Proteins; NEM Sensitive Fusion Proteins

Networked: 60 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hu, Bingren: 5 articles (11/2021 - 01/2018)
2.	Liu, Chunli: 5 articles (11/2021 - 01/2018)
3.	Yuan, Dong: 4 articles (11/2021 - 01/2018)
4.	Mukhopadhyay, Somshuvra: 3 articles (11/2008 - 03/2007)
5.	Sehgal, Pravin B: 3 articles (11/2008 - 03/2007)
6.	Lowenstein, Charles J: 3 articles (12/2007 - 10/2003)
7.	Hu, Kurt: 2 articles (11/2021 - 01/2021)
8.	Teramoto, Hironori: 2 articles (11/2021 - 01/2021)
9.	Dolai, Subhankar: 2 articles (10/2021 - 01/2020)
10.	Gaisano, Herbert Y: 2 articles (10/2021 - 01/2020)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 11/01/2021 - "This study investigates the cascades of NSF ATPase inactivation events, endolysosomal damage, cathepsin release, and neuronal death after focal brain ischemia. " 01/01/2018 - "This review article is to discuss a novel hypothesis that brain ischemia inactivates NSF ATPase, resulting in a cascade of events of disruption of the Golgi-endosome-lysosome pathway, release of cathepsin B (CTSB), and induction of mitochondrial outer membrane permeabilization (MOMP) during the postischemic phase. " 12/01/2014 - "Identification of differentially expressed proteins and validation of the changes of N-ethylmaleimide-sensitive factor in rats with focal cerebral ischemia after transection of the cervical sympathetic trunk." 01/01/2021 - "Brain ischemia damages the membrane fusion machinery co-operated by N-ethylmaleimide sensitive factor (NSF), soluble NSF attachment protein (SNAP), and soluble NSF attachment protein receptors (SNAREs), thus interrupting the membrane-to-membrane fusion between the late endosome and terminal lysosome. " 01/01/2018 - "This study is to investigate the cascade of events of NSF ATPase inactivation, resulting in a massive buildup of late endosomes (LEs) and fatal release of cathepsin B (CTSB) after transient cerebral ischemia using the 2-vessel occlusion with hypotension (2VO+Hypotension) global brain ischemia model. "
2.	Transient Ischemic Attack 01/01/2004 - "Alterations of N-ethylmaleimide-sensitive atpase following transient cerebral ischemia." 01/01/2018 - "Correction to: Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia." 01/01/2018 - "Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia." 01/01/2018 - "This study is to investigate the cascade of events of NSF ATPase inactivation, resulting in a massive buildup of late endosomes (LEs) and fatal release of cathepsin B (CTSB) after transient cerebral ischemia using the 2-vessel occlusion with hypotension (2VO+Hypotension) global brain ischemia model. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2018 - "Laboratory studies included APOL1 association with vesicle-associated membrane soluble N-ethylmaleimide-sensitive factor activating protein receptor protein and with soluble urokinase-type plasminogen activator receptor, mitochondrial dysfunction, endolysosomal dysfunction, and inflammasome activation. "
4.	Hyperoxia 01/01/2013 - "Here, the effects of vitamin E on hyperoxia-induced changes in the expressions of N-ethylmaleimide-sensitive factor (NSF) and soluble NSF-attachment protein α (α-SNAP) in the rat brain were analyzed. " 01/01/2013 - "Vitamin E prevents hyperoxia-induced loss of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor proteins in the rat neuronal cytoplasm." 01/01/2013 - "This study examines the ability of vitamin E to inhibit hyperoxia-induced loss of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) proteins in the neuronal cytoplasm. "
5.	Tetanus 07/05/2018 - "Moreover, CGN represent a convenient model for the study of Clostridial Neurotoxins (CNT), most notably known as Tetanus and Botulinum neurotoxins, as they abundantly express both CNT receptors and intraneuronal substrates, i.e., Soluble N-ethylmaleimide-sensitive factor activating protein receptors (SNARE proteins). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	SNARE Proteins (SNAREs)
3.	Cathepsin B
4.	Botulinum Toxins (Botulinum Toxin)
5.	Neurotoxins
6.	Inflammasomes
7.	Urokinase Plasminogen Activator Receptors
8.	Small Interfering RNA (siRNA)
9.	Vitamin E
10.	Cathepsins

Related Therapies and Procedures

1.	Therapeutics