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Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)

A subtype of bone morphogenetic protein receptors with low affinity for BONE MORPHOGENETIC PROTEINS. They are constitutively active PROTEIN SERINE-THREONINE KINASES that can interact with and phosphorylate TYPE I BONE MORPHOGENETIC PROTEIN RECEPTORS.
Also Known As:
Bone Morphogenetic Protein Receptor Type II; Receptor, BMPR2; Bone Morphogenetic Protein Receptors, Type II; BMP Type II Receptor; BMP Type II Receptors; BMPR-II Receptor; BMPR2 Receptor; Bone Morphogenetic Protein Receptor II; Receptor, Type II BMP; BMPR II Receptor; Receptor, BMPR-II
Networked: 138 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Morrell, Nicholas W: 30 articles (01/2022 - 03/2006)
2. Upton, Paul D: 12 articles (01/2021 - 02/2008)
3. Long, Lu: 11 articles (01/2020 - 03/2006)
4. Yang, Jun: 8 articles (01/2022 - 05/2008)
5. Southwood, Mark: 8 articles (01/2020 - 03/2006)
6. Humbert, Marc: 6 articles (12/2019 - 01/2013)
7. Davies, Rachel J: 6 articles (03/2012 - 05/2008)
8. Crosby, Alexi: 5 articles (01/2020 - 02/2009)
9. Girerd, Barbara: 5 articles (01/2018 - 01/2013)
10. Yang, Xudong: 5 articles (01/2017 - 03/2006)

Related Diseases

1. Pulmonary Arterial Hypertension
2. Pulmonary Hypertension
3. Familial Primary Pulmonary Hypertension
4. Hypoxia (Hypoxemia)
06/22/2011 - "We hypothesized that early endoplasmic reticulum (ER) stress, which is associated with clinical triggers of PAH including hypoxia, bone morphogenetic protein receptor II mutations, and HIV/herpes simplex virus infections, explains the mitochondrial abnormalities and has a causal role in PAH. "
01/01/2014 - "In this study, using intestinal epithelial cells under anaerobic cultivation and an in vivo rat intestinal I/R model, we found that hypoxia and I/R increased the expression of BMP2/4 and upregulated BMP type Ia receptor and BMP type II receptor expression. "
01/01/2019 - "The regulation of ET-1 by iron was also demonstrated in healthy humans exposed to hypoxia and in PASMCs from PAH patients with mutations in bone morphogenetic protein receptor type II. Such mutations were further associated with dysregulation of the HAMP/FPN axis in PASMCs. "
03/15/2012 - "Putative miR-21 targets, including bone morphogenetic protein receptor (BMPR2), WWP1, SATB1, and YOD1, were downregulated in the lungs of hypoxia-exposed mice and in human pulmonary artery smooth muscle cells (PASMCs) overexpressing miR-21. "
01/01/2019 - "Furthermore, administration of BBR significantly increased the expression of bone morphogenetic protein type II receptor (BMPR-II) and its downstream molecules P-smad1/5 and decreased the expression of transforming growth factor-β (TGF-β) and its downstream molecules P-smad2/3. Moreover, peroxisome proliferator-activated receptor γ expression was significantly decreased in the hypoxia group, and this decrease was reversed by BBR treatment. "
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
2. hydralazine 4-anisaldehyde hydrazone
3. Transforming Growth Factors (Transforming Growth Factor)
4. Proteins (Proteins, Gene)
5. Transforming Growth Factor beta (TGF-beta)
6. Estrogens (Estrogen)
7. Type I Bone Morphogenetic Protein Receptors
8. Serotonin (5 Hydroxytryptamine)
9. Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)
10. Vasodilator Agents (Vasodilators)

Related Therapies and Procedures

1. Liver Transplantation