Phospholipase C gamma

A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of SRC HOMOLOGY DOMAINS and pleckstrin homology domains located between two halves of the CATALYTIC DOMAIN.

Also Known As:

Networked: 118 relevant articles (1 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cremasco, Viviana: 4 articles (03/2010 - 06/2008)
2.	Faccio, Roberta: 4 articles (03/2010 - 06/2008)
3.	Kassis, J: 3 articles (05/2007 - 04/2001)
4.	Wells, A: 3 articles (05/2007 - 04/2001)
5.	Katan, Matilda: 2 articles (08/2009 - 04/2005)
6.	Yu, Philipp: 2 articles (08/2009 - 04/2005)
7.	Bunney, Tom D: 2 articles (08/2009 - 04/2005)
8.	Fuchs, Helmut: 2 articles (08/2009 - 04/2005)
9.	Auger, Jocelyn M: 2 articles (07/2009 - 05/2008)
10.	Watson, Steve P: 2 articles (07/2009 - 05/2008)

Related Diseases

1.	Infection 07/15/2005 - "Why PLCgamma2 is more important than PLCgamma1 for NK cell activation and whether PLCgamma2 is also critical for NK cell development, secretion of IFN-gamma, and clearance of viral infections in vivo is not known. " 07/15/2005 - "Consequently, mice lacking PLCgamma2 controlled murine CMV infection substantially less effectively than did wild-type animals, and this defect was most evident in the spleen, where viral clearance mostly depends on NK cell lytic function. " 03/15/1995 - "TCR/CD3-induced tyrosine phosphorylation of the intracellular enzyme phospholipase-C gamma 1 and the surface receptor/substrates CD5 and CD6 was unaffected by virus infection, whereas augmented responses normally observed after the co-ligation of CD4 with TCR/CD3 on T lymphocytes were absent in HIV-1-infected H9 cells. "
2.	Neoplasms (Cancer) 12/01/2009 - "Activated Akt binds and phosphorylates PLC(gamma) before Akt targets the tumor suppressor Chfr. " 05/17/2001 - "Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion." 08/01/1999 - "A role for phospholipase C-gamma-mediated signaling in tumor cell invasion." 03/01/1999 - "These results support a key role for PLC-gamma activation as a common postreceptor pathway for GF-induced tumor infiltration and further identify PLC-gamma1 as a possible target for anti-invasive therapy for GBMs." 06/01/1996 - "However, at 37 weeks post-injection, dietary fiber significantly altered DAG (P < 0.02), and PLC-gamma1 expression (P < 0.05) in the absence of an effect on tumor incidence. "
3.	Inflammation 03/01/2010 - "These studies position PLCgamma2 as a critical regulator of the cellular and molecular mechanisms occurring in bone and immune cells during autoimmune inflammation." 04/01/2005 - "Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry." 09/01/2008 - "This study identifies a Vav/PLCgamma2-dependent signaling pathway as a possible therapeutic target for the treatment of inflammation and bone disruption in arthritis." 01/01/2010 - "Utilizing a T cell-dependent model of arthritis, we find that PLCgamma2-/- mice are protected from local inflammation and bone erosion. " 09/01/2008 - "Vav(null) and PLCgamma2(-/-) mice were protected from inflammation and bone erosion in the K/BxN serum-transfer model of arthritis. "
4.	Arthritis (Polyarthritis) 01/01/2010 - "This study demonstrates a critical role for PLCgamma2 in eliciting inflammatory responses by regulating actin dynamics in DCs and positions the PLCgamma2 pathway as a common orchestrator of bone and immune cell functions during arthritis." 03/01/2010 - "Indeed PLCgamma2(-/-) mice are protected from K/BxN serum transfer arthritis, which is known to require neutrophil activation. " 01/01/2010 - "Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells." 03/16/2009 - "PLCgamma2 deficiency completely protected mice from clinical signs and histological features of arthritis as well as from arthritis-induced loss of articular function. " 09/01/2008 - "Arthritis was induced in wild-type (WT), Vav(null), and PLCgamma2(-/-) mice using the K/BxN serum-transfer model. "
5.	Carcinoma (Carcinomatosis) 05/01/2008 - "Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion." 01/01/1994 - "By radioimmunoassay and Western blotting, PLC-gamma 1 showed three-fold to fourfold more expression in carcinomas than that in normal tissues. " 01/01/2012 - "Notably, PLC-gamma is up-regulated in colorectal cancer tissue and breast carcinoma. " 04/15/1994 - "Likewise, activity of PLC-gamma 1 was considerably higher in adenomas and carcinomas than in normal mucosa. " 04/15/1994 - "The level of PLC-gamma 1 expression increased from normal mucosa to adenoma, and finally to carcinoma progressively. "

Related Drugs and Biologics

1.	Phospholipase C gamma
2.	Cisplatin (Platino)
3.	Tyrosine (L-Tyrosine)
4.	Phosphotransferases (Kinase)
5.	Epidermal Growth Factor Receptor (EGF Receptor)
6.	Type C Phospholipases
7.	Epidermal Growth Factor (EGF)
8.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
9.	Phospholipases (Phospholipase)
10.	Fc Receptors (Fc Receptor)

Related Therapies and Procedures

1.	Ligation
2.	Lasers (Laser)