Smad4 Protein

A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.

Also Known As:

Networked: 90 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cao, Xu: 4 articles (09/2006 - 05/2005)
2.	Tang, Yi: 3 articles (09/2006 - 05/2005)
3.	Wan, Mei: 3 articles (09/2006 - 05/2005)
4.	Wang, Ning: 3 articles (09/2006 - 05/2005)
5.	Jiang, Jing: 2 articles (03/2020 - 09/2015)
6.	Liu, Nannan: 2 articles (03/2020 - 09/2015)
7.	Yu, Chunyan: 2 articles (03/2020 - 09/2015)
8.	Beauchamp, R Daniel: 2 articles (01/2018 - 02/2007)
9.	Cowland, Jack Bernard: 2 articles (01/2018 - 12/2011)
10.	Washington, M Kay: 2 articles (01/2018 - 02/2007)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2023 - "The staining characteristic of SMAD4 protein was negative in the cancer tissues of the patients with cSCC (p = 0.00). " 01/28/2021 - "In addition, patients with low SMAD4 protein expression in primary tumors more often presented with metastatic disease. " 08/01/2015 - "Considering that dosage dependence is of great importance for the role of SMAD4 protein as a tumor suppressor, potential clinical significance of SMAD4 gene promoter mutations is worth further investigation." 08/01/2015 - "The expression and intracellular localization of endogenous SMAD4 protein in selected tumor samples was studied by immunostaining and confocal microscopy. " 11/01/2011 - "Smad4 protein was expressed in 61.5% (24/39), 53.1% (77/145), 41.3% (78/189) and 34.8% (16/46) of stage I, II, III and IV cancers, respectively. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "Our study demonstrated high frequency of Smad4 alterations with low expression of Smad4 protein identifying a subgroup of aggressive colorectal cancer to be an independent marker for poor prognosis. " 02/15/2007 - "Loss of Smad4 protein expression is correlated with poor prognosis and is frequently observed in invasive and metastatic colorectal carcinoma. " 11/01/2011 - "Smad4 protein is of no value in predicting recurrence after curative therapy in colorectal cancer, but it may be helpful in identifying a subset of patients with early recurrence after curative therapy." 09/07/2020 - "Meanwhile, DUSP4 can directly deubiquitinate and stabilize Smad4 protein, hence further promote proliferation and metastasis of colorectal cancer cells." 09/07/2020 - "DUSP4 directly deubiquitinates and stabilizes Smad4 protein, promoting proliferation and metastasis of colorectal cancer cells."
3.	Hypoxia (Hypoxemia) 04/01/2011 - "However, treatment with hypoxia caused a marked decrease in nuclear and cytosolic SMAD4 protein and SMAD4 mRNA expression in cocultured HuH7 cells. "
4.	Neoplasm Metastasis (Metastasis) 12/04/2006 - "Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification." 01/28/2021 - "Hemizygous loss of chromosome 18q and the SMAD4 gene is the most common genetic event in SINETs and our results suggests that this could influence SMAD4 protein expression and spread of metastases. " 01/01/2021 - "LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway." 11/15/2012 - "Matched primary and metastasis tissues were evaluated for intragenic mutations in KRAS, CDKN2A, and TP53 and immunolabeled for CDKN2A, TP53, and SMAD4 protein products. " 05/01/2007 - "Absence of Smad4 protein was more frequently observed in hepatic metastases, whether they were metachronous or synchronous, than in extrahepatic metastases (p<0.005). "
5.	Carcinoma (Carcinomatosis) 10/01/2019 - "Loss of SMAD4 protein expression in gastrointestinal and extra-gastrointestinal carcinomas." 01/27/2005 - "In 41 primary squamous cervical carcinomas analysed, 10 samples showed loss of Smad4 protein expression and 26 samples a reduced expression. " 01/01/2004 - "To further elucidate the role of SMAD4 dysfunction for tumor development in the small intestine, we immunohistochemically analyzed 20 sporadic, non-ampullary carcinomas for the expression of the SMAD4 protein. " 01/01/2007 - "SMAD4 protein levels were also affected in certain gastric carcinoma cell lines following incubation with MG132. " 07/01/2006 - "In poorly-differentiated carcinoma, Smad4 protein expression was retained and may be linked to TGF-beta2 overexpression, due to the activation or deregulation of the TGF-fl signalling pathway. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Valproic Acid (Depakote)
3.	Proteins (Proteins, Gene)
4.	Transforming Growth Factor beta (TGF-beta)
5.	Transforming Growth Factor beta1 (TGF beta 1)
6.	Ubiquitin
7.	Biomarkers (Surrogate Marker)
8.	Transforming Growth Factors (Transforming Growth Factor)
9.	DNA (Deoxyribonucleic Acid)
10.	Transforming Growth Factor beta2

Related Therapies and Procedures

1.	Therapeutics
2.	Pancreaticoduodenectomy