Smad3 Protein

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	James, Christine: 1 article (03/2022)
2.	Peterson, Diane C: 1 article (03/2022)
3.	Aaron, Nicole: 1 article (12/2021)
4.	Chen, Jinghong: 1 article (12/2021)
5.	Fan, Lihong: 1 article (12/2021)
6.	Fang, Qian: 1 article (12/2021)
7.	Feng, Yiping: 1 article (12/2021)
8.	He, Ying: 1 article (12/2021)
9.	Ma, Tianyou: 1 article (12/2021)
10.	Sun, Jian: 1 article (12/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Targeting the SMAD3 protein is an attractive therapeutic strategy for treating cancer, as it avoids the potential toxicities due to targeting the TGF-β signaling pathway upstream. " 01/01/2019 - "Screening of several TNBC cell lines showed altered Smad2 and Smad3 protein levels compared to normal mammary epithelial cells, suggesting the possibility that it could play an important role in the escape of cancer cells from TGF-β mediated growth inhibition. " 08/03/2017 - "Pin1 depletion restored Smad3 protein levels and tumor-suppressive activity, suggesting that the Pin1-Smad3 interaction has a negative impact on canonical Smad3 action. " 10/01/2013 - "Cumulative results provide compelling evidence that DEAR1 is a critical tumor suppressor involved in multiple human cancers and provide a novel paradigm for regulation of TGF-β-induced EMT through DEAR1's regulation of SMAD3 protein levels. " 10/02/2023 - "Our study found that the Smad3 protein is overexpressed in 143B and U2OS cells, suppressing the expression of Smad3 protein in osteosarcoma cells by Smad3 target inhibitor (E)-SIS3 or lentivirus can inhibit the proliferation, migration, invasion, promote cell apoptosis, arrest cell G1 cycle in osteosarcoma cells in vitro, and suppress tumor growth in vivo. "
2.	Stroke (Strokes) 09/01/2018 - "In the current study, we determined the infarct size and TGF-β1/Smad3 protein expression in stroke-induced rats. "
3.	Osteosarcoma (Osteogenic Sarcoma) 10/02/2023 - "Our study found that the Smad3 protein is overexpressed in 143B and U2OS cells, suppressing the expression of Smad3 protein in osteosarcoma cells by Smad3 target inhibitor (E)-SIS3 or lentivirus can inhibit the proliferation, migration, invasion, promote cell apoptosis, arrest cell G1 cycle in osteosarcoma cells in vitro, and suppress tumor growth in vivo. "
4.	Infarction (Infarctions) 09/01/2018 - "In the current study, we determined the infarct size and TGF-β1/Smad3 protein expression in stroke-induced rats. "
5.	Fibrosis (Cirrhosis) 03/01/2022 - "Because the Smad3 protein has been previously implicated in COVID-19-associated tissue fibrosis, it may play a role in endothelial dysfunction as well." 01/01/2018 - "In conclusion, MPOE could effectively attenuate hepatic fibrosis mainly through improving the redox status, suppressing p53 and subsequently modulating TGF-β1 and SMAD3 protein expression. " 01/01/2020 - "Results are presented as follows: (a) MiR-182 was positively correlated with fibrosis of cyst-lined epithelial cells; (b) TGF-β1 could induce fibrosis of cyst-lined epithelial cells; (c) the expression of miR-182 had a remarkably impact on the fibrosis induced by TGF-β1, but had little effect on the expression of TGF-β1; (d) the expression of Smad3 protein in TGF-β1 induce-cyst-lined epithelial cells was increased. "

Related Drugs and Biologics

1.	Transforming Growth Factors (Transforming Growth Factor)
2.	Transforming Growth Factor beta1 (TGF beta 1)
3.	Smad7 Protein
4.	Smad2 Protein
5.	Silk
6.	Small Interfering RNA (siRNA)
7.	Mitogen-Activated Protein Kinases
8.	Protein Isoforms (Isoforms)
9.	Chemokines
10.	Transforming Growth Factor beta (TGF-beta)

Related Therapies and Procedures

1.	Hepatectomy