Inhibitory Smad Proteins

A sub-family of smad proteins that inhibit cell signaling by RECEPTOR-REGULATED SMAD PROTEINS. They form autoinhibitory feedback loops in the TGF-BETA signaling pathway and mediate signaling cross-talk with other signaling pathways

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bewersdorf, Jan Philipp: 1 article (01/2019)
2.	Zeidan, Amer M: 1 article (01/2019)
3.	Ma, Mingyue: 1 article (10/2017)
4.	Xiao, Chunling: 1 article (10/2017)
5.	Yang, Biao: 1 article (10/2017)
6.	Yang, Dan: 1 article (10/2017)
7.	Zhou, Weiqiang: 1 article (10/2017)
8.	Bauskin, Asne R: 1 article (02/2006)
9.	Breit, Samuel N: 1 article (02/2006)
10.	Brown, David A: 1 article (02/2006)

Related Diseases

1.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/01/2019 - "TGF-β receptor activation and phosphorylation trigger a regulatory circuit of activating and inhibitory SMAD proteins and increased activation of the TGF-β signaling pathway either by a loss of negative feedback or constitutive activation has been associated with the myelosuppression and ineffective erythropoiesis in myelodysplastic syndromes (MDS). "
2.	Lung Neoplasms (Lung Cancer) 10/01/2017 - "The results showed that treatment with PM2.5 promoted the activity of the SMAD family member 1 (Smad1)-mediated signaling pathway and downregulated the expression of the inhibitory Smad proteins Smad6 and Smad7 in lung cancer cells. "
3.	Hypertrophy 02/17/2006 - "Overexpression of SMAD2 attenuated cardiomyocyte hypertrophy similar to GDF15 treatment, whereas overexpression of the inhibitory SMAD proteins, SMAD6/7, reversed the antihypertrophic effects of GDF15. "