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Notch Receptors

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
Also Known As:
Receptors, Notch; Notch Proteins; Protein, Notch; Receptor, Notch; Notch Protein; Notch Receptor
Networked: 475 relevant articles (4 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Miele, Lucio: 10 articles (01/2016 - 09/2005)
2. Aster, Jon C: 8 articles (01/2020 - 01/2003)
3. Carbone, David P: 6 articles (01/2019 - 09/2007)
4. Han, Hua: 6 articles (12/2015 - 04/2007)
5. Radtke, Freddy: 6 articles (12/2012 - 03/2003)
6. Egan, Sean E: 5 articles (10/2014 - 09/2005)
7. Blacklow, Stephen C: 5 articles (10/2011 - 01/2003)
8. Wolfe, Michael S: 5 articles (04/2009 - 01/2003)
9. Canalis, Ernesto: 4 articles (01/2020 - 02/2012)
10. Shanker, Anil: 4 articles (01/2019 - 10/2015)

Related Diseases

1. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
2. Multiple Myeloma
3. Bone Diseases (Bone Disease)
4. Inflammation (Inflammations)
01/01/2023 - "In this issue of the JCI, Benamar et al. demonstrated the critical role of the Notch receptor 1/CD22 (Notch1/CD22) axis in Tregs, which, when activated, impairs Treg functions and promotes inflammation. "
01/01/2020 - "Notch4 is a member of the Notch receptor family and may be a negative regulator of Mtb-induced inflammation. "
08/01/2008 - "We propose a calcification model where extreme increases in vascular wall cell density due to inflammation-induced cell proliferation can trigger an osteogenic differentiation program mediated by Notch receptors."
01/01/2023 - "Such privileged channels of material-to-cell communication can activate synthetic Notch receptors and govern activities as diverse as transcriptome engineering, inflammation attenuation, and pluripotent stem cell differentiation, all in response to materials decorated with otherwise bioinert ligands. "
12/01/2015 - "However, mice lacking RBP-J, the critical transcription factor mediating signals from all four mammalian Notch receptors, in myeloid lineage displayed promoted functional recovery, attenuated glial scar formation, improved neuronal survival and axon regrowth, and mitigated inflammatory response after SCI. These benefits were accompanied by enhanced AKT activation in the lesion area after SCI. These findings demonstrate that abrogating Notch signal in myeloid cells ameliorates inflammation response post-SCI and promotes functional recovery, but general pharmaceutical Notch interception has opposite effects. "
5. Kidney Diseases (Kidney Disease)

Related Drugs and Biologics

1. Transcription Factors (Transcription Factor)
2. Catenins
3. Blocking Antibodies
4. RNA (Ribonucleic Acid)
5. XAV939
6. Ligands
7. Proteins (Proteins, Gene)
8. Messenger RNA (mRNA)
9. Chemokine Receptors
10. Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1. Therapeutics
2. Acupuncture Points (Acupuncture Point)
3. Moxibustion
4. Lasers (Laser)
5. Drug Therapy (Chemotherapy)