Twist-Related Protein 1

A basic helix-loop-helix transcription factor that was originally identified in DROSOPHILA as essential for proper gastrulation and MESODERM formation. It plays an important role in EMBRYONIC DEVELOPMENT and CELL DIFFERENTIATION of MUSCLE CELLS, and is found in a wide variety of organisms.

Also Known As:

Networked: 114 relevant articles (0 outcomes, 13 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yang, Jing: 4 articles (12/2017 - 06/2004)
2.	He, Tao: 3 articles (06/2020 - 06/2011)
3.	Fu, Junjiang: 3 articles (05/2016 - 06/2011)
4.	Mani, Sendurai A: 3 articles (03/2012 - 06/2004)
5.	Li, Jie: 2 articles (01/2022 - 11/2014)
6.	Li, Liang: 2 articles (01/2022 - 01/2020)
7.	Liu, Zhiqiang: 2 articles (01/2022 - 12/2017)
8.	Ho, Chi-Tang: 2 articles (12/2021 - 03/2017)
9.	Li, Yan: 2 articles (12/2021 - 01/2021)
10.	Zhang, Jing: 2 articles (01/2020 - 04/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Furthermore, we demonstrated that RBX1 knockdown increased the levels of the Twist family bHLH transcription factor 1 (TWIST1), is a significant regulator in the EMT process in some cancers. " 02/08/2021 - "The invasive ability of cancer cells was found to be decreased by the regulation of Twist1 protein levels. " 12/01/2019 - "Together, our findings indicate that HR23A importantly contributes to regulating Twist1 protein stability, and suggest that altering the stability of Twist1 by modulating HR23A may be a new avenue for therapeutic intervention in cancer." 12/01/2019 - "Depletion of HR23A enhances Twist1 protein levels, epithelial-mesenchymal transition, cancer cell migration and various cancer stemness properties, including the expression of major pluripotency factors, the capacity for tumor-sphere formation in culture and the expression of cancer stem cell surface markers. " 02/04/2019 - "The Twist protein expression level was detected in 120 cases of cancer tissues and a control group using immunohistochemical method. "
2.	Neoplasm Metastasis (Metastasis) 10/01/2018 - "Furthermore, miR-153 knockdown decreased Twist family BHLH transcription factor 1 and metastasis-associated 1 family member 3 expression in LSCC cells. " 09/01/2007 - "And up-regulated Twist protein was significantly associated with intrahepatic and extrahepatic metastasis (p=0.048 and P=0.039 respectively). " 05/01/2006 - "Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. " 09/01/2019 - "More recently, a highly conserved transcription factor Twist has been reported to be involved in tumor angiogenesis and metastasis. " 08/01/2019 - "Twist-related protein 1 (TWIST1) plays an essential role in the carcinogenesis and metastasis of NSCLC. "
3.	Breast Neoplasms (Breast Cancer) 07/01/2021 - "Clinical specimens and pathological characteristics were collected for evaluating the expression of forkhead box class O 3a (FOXO3a) and twist-related protein 1 (TWIST-1) in breast cancer tissues. " 01/01/2020 - "Mechanistically, Twist-related protein 1 (TWIST1) was negatively associated with TFPI2 in breast cancer patients, whose expression was decreased by TFPI2 over-expression or increased by TFPI2 knockdown. " 01/01/2017 - "Despite initial indications that the transcription factor Twist could be used as a breast cancer prognostic marker, there still exists some controversy about its reliability. " 01/01/2022 - "We have found that miR-381 can regulate the proliferation of breast cancer cells by regulating TWIST protein, it can serve as a potential marker for the tumor progression. " 01/01/2016 - "Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein."
4.	Squamous Cell Carcinoma of Head and Neck 03/01/2020 - "The current study aims to assess the expression of TWIST protein in oral squamous cell carcinoma (OSCC), epithelial dysplasia (ED), and normal oral mucosa to verify whether such protein is useful as a marker in oral epithelium malignant transformation. " 03/01/2015 - "Twist-related protein 1 enhances oral tongue squamous cell carcinoma cell invasion through β-catenin signaling." 10/01/2015 - "The objective of this paper was to study the expression of related protein and Twist transcription factor of epithelial-mesenchymal transition in oral squamous cell carcinoma (OSCC) tissue and the correlations of OSCC and oral squamous cell carcino-metastasis. "
5.	Carcinoma (Carcinomatosis) 10/01/2007 - "The expression of TWIST protein in these cell lines and 14 pairs of fresh gastric carcinoma and adjacent normal tissue samples was detected by Western blotting. " 01/01/2017 - "In this study, immunohistochemistry and western blot analysis revealed that the expression of HMGA2 and Twist-related protein 1 (TWIST1) in gastric carcinoma tissues was higher than that in the peritumoral tissues and that the expression levels of these two proteins were positively correlated. " 11/01/2015 - "Twist-related protein 1 (Twist1), is a class II basic helix-loop-helix transcription factor, which has been demonstrated to be a major regulator of epithelial-mesenchymal transition (EMT), and therefore is involved in promoting carcinoma metastasis. " 03/01/2008 - "The transcription factor Twist protein has been found to be correlated with metastasis in various carcinomas, including hepatocellular, breast and prostate carcinomas. " 07/01/2021 - "The nuclear transcription factor twist-related protein 1 (Twist1) is associated with tumor malignant transformation and metastasis in various types of carcinomas. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cadherins (E-Cadherin)
3.	Messenger RNA (mRNA)
4.	Metalloproteases (Metalloproteinases)
5.	Biomarkers (Surrogate Marker)
6.	Doxorubicin (Adriamycin)
7.	Vimentin
8.	Basic Helix-Loop-Helix Transcription Factors
9.	Transcription Factors (Transcription Factor)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Neoadjuvant Therapy
3.	Therapeutics
4.	Sutures (Suture)