Kangai-1 Protein (Kangai 1 Protein)

01/01/2001 - "The disease-free patients (n=10) showed overexpression of KAI1 protein, compared to those with disease progression (n=6). "
01/01/2001 - "These results indicate that progression arose mainly in the patients with stage A2 cancer, and that poorly differentiated, focal and weak expression of KAI1 protein is highly associated with disease progression. "

07/01/2000 - "In immunohistochemical study, decrease of KAI1 protein expression was associated with the progression of ovarian tumor. "
05/01/2009 - "In all 10 tumor-free kidneys KAI1 protein was detected exclusively in distal tubule cell membranes. "
02/01/2004 - "In univariate and multivariate analyses, decreased expression of KAI1 protein, stage pT1, tumor size >3 cm and sessile tumors were independent prognosis factors of recurrence. "
02/01/2004 - "Decreased expression of KAI1 protein failed to reach statistical significance for stage (P = 0.25) or morphology of tumor stem (P = 0.19), but it was significantly related to tumor size (P = 0.016). "
04/01/2003 - "Using the method of immunohistochemistry, we characterized the KAI1 protein expression in the 143 endometrial tumors. "

08/01/1999 - "Recent studies have demonstrated that the expression of KAI1 protein is reduced in metastases of human prostate cancers and is inversely correlated with tumour grade. "
11/01/2000 - "Loss of KAI1 protein is a frequent event in various types of cancer and has been reported to be associated with increased rate of metastasis and shorter survival time. "
11/01/1999 - "Western blot analysis showed a highly significant increase of KAI1 protein level in stage II cancers in comparison with the normal colon (P < .001) but also in comparison with the more advanced tumor stages III and IV (P < .03) and P < .02, respectively), when metastases were already present. "
12/28/2019 - "Multi-factor analysis showed that the expression of vasohibin-1, KAI1 protein and the FIGO stage were independent prognosis factors for radical operation of serous ovarian cancer (RR=2.185, 3.893, 0.413; 95% CI=1.263-3.779, 2.190-6.921, 0.251-0.681; all P<0.05).
 Conclusion: The up-regulation of vasohibin-1, MACC1 and down-regulation of KAI1 in serous ovarian cancer are related to the tumor differentiation, clinical stage, metastasis and prognosis. "
09/01/1999 - "Immunohistochemical staining showed that in one case without metastasis, loss of KAI1 mRNA was associated with invasion of the stroma by KAI1 protein-negative cancer cells. "

01/01/2017 - "KAI1 protein levels in human prostate cancer tissue samples were examined by immunofluorescence staining of the tissues with an anti-KAI1 antibody. "
10/01/1996 - "These results demonstrate that KAI1 protein expression is consistently down-regulated during the progression of human prostatic cancer and that this down-regulation does not commonly involve either mutation or allelic loss of the KAI1 gene."
10/01/1996 - "KAI1 protein expression is downregulated in more than 70% of the 49 primary prostatic cancers from untreated patients. "
08/01/1999 - "Recent studies have demonstrated that the expression of KAI1 protein is reduced in metastases of human prostate cancers and is inversely correlated with tumour grade. "
11/01/1996 - "These results indicate that the expression of KAI1 protein correlates to tumor characteristics in prostate cancer."

09/01/2000 - "In this study, we examined KAI1 protein expression in breast cancer cell lines by Western blot and immunohistochemical study. "
09/01/2000 - "Furthermore, we examined KAI1 protein expression immunohistochemically in specimens from 81 patients with breast cancer and then correlated the findings with the clinical and histopathological parameters of the patients. "
09/01/2000 - "KAI1 protein is down-regulated during the progression of human breast cancer."
09/01/2000 - "High levels of KAI1 protein expression were found in normal breast tissues and noninvasive breast cancer (ductal carcinoma in situ). "
07/01/2000 - "Decreased KAI1 expression seems to be involved in the progression of human prostate, lung, pancreatic, and possibly breast cancer, and recently a reduced KAI1 protein expression has been demonstrated in several ovarian carcinoma cell lines. "